Combined effects of global DNA methylation, blood lead and total urinary arsenic levels on developmental delay in preschool children
Abstract DNA methylation is a critical step in brain development, 5-Methyl-2'-deoxycytidine (5mdC) is one of the global DNA methylation markers. Arsenic and lead exposures have been associated with neurotoxicity, which may be linked to epigenetic changes. Our research sought to investigate the...
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BMC
2025-01-01
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| Online Access: | https://doi.org/10.1186/s12940-024-01151-6 |
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| author | Yuu-Hueih Hsu Chih-Yin Wu Hui-Ling Lee Ru-Lan Hsieh Ya-Li Huang Horng-Sheng Shiue Ying-Chin Lin Mei-Chieh Chen Yu-Mei Hsueh |
| author_facet | Yuu-Hueih Hsu Chih-Yin Wu Hui-Ling Lee Ru-Lan Hsieh Ya-Li Huang Horng-Sheng Shiue Ying-Chin Lin Mei-Chieh Chen Yu-Mei Hsueh |
| author_sort | Yuu-Hueih Hsu |
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| description | Abstract DNA methylation is a critical step in brain development, 5-Methyl-2'-deoxycytidine (5mdC) is one of the global DNA methylation markers. Arsenic and lead exposures have been associated with neurotoxicity, which may be linked to epigenetic changes. Our research sought to investigate the correlation between 5mdC and developmental delay (DD) among preschoolers. Additionally, we assessed whether 5mdC modified the impacts of blood lead and total urinary arsenic levels on DD. We analyzed the concentrations of 5mdC, blood cadmium and lead, and total urinary arsenic in 174 children with DD and 88 healthy children. Global DNA methylation levels are expressed as the ratio 5mdC/2’-dexyguanosine (dG), called 5mdC (%). In our findings, elevated levels of blood lead and total urinary arsenic were significantly associated with DD risk among preschoolers. Furthermore, high 5mdC (%) was related with reduced risk of DD, with an odds ratio (OR) and 95% confidence interval (CI) of 0.14 (0.06 – 0.32). A notable multiplicative interaction was observed between low 5mdC (%) and elevated blood lead levels to increase OR of DD, with OR and 95% CI was 9.51 (4.18 – 21.64). The findings provide evidence of the combined effects of reduced 5mdC (%) and high blood lead concentrations, increasing the OR of DD. |
| format | Article |
| id | doaj-art-508d142752be4304a131de800e1a89dd |
| institution | Kabale University |
| issn | 1476-069X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Environmental Health |
| spelling | doaj-art-508d142752be4304a131de800e1a89dd2025-01-19T12:37:41ZengBMCEnvironmental Health1476-069X2025-01-0124111010.1186/s12940-024-01151-6Combined effects of global DNA methylation, blood lead and total urinary arsenic levels on developmental delay in preschool childrenYuu-Hueih Hsu0Chih-Yin Wu1Hui-Ling Lee2Ru-Lan Hsieh3Ya-Li Huang4Horng-Sheng Shiue5Ying-Chin Lin6Mei-Chieh Chen7Yu-Mei Hsueh8Department of Public Health, National Cheng Kung UniversityDepartment of Family Medicine, Wan Fang Hospital, Taipei Medical UniversityDepartment of Chemistry, Fu Jen Catholic UniversityDepartment of Physical Medicine and Rehabilitation, Su Memorial HospitalDepartment of Public Health, School of Medicine, College of Medicine, Taipei Medical UniversityDepartment of Chinese Medicine, College of Medicine, Chang Gung UniversityDepartment of Family Medicine, Wan Fang Hospital, Taipei Medical UniversityDepartment of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical UniversityDepartment of Family Medicine, Wan Fang Hospital, Taipei Medical UniversityAbstract DNA methylation is a critical step in brain development, 5-Methyl-2'-deoxycytidine (5mdC) is one of the global DNA methylation markers. Arsenic and lead exposures have been associated with neurotoxicity, which may be linked to epigenetic changes. Our research sought to investigate the correlation between 5mdC and developmental delay (DD) among preschoolers. Additionally, we assessed whether 5mdC modified the impacts of blood lead and total urinary arsenic levels on DD. We analyzed the concentrations of 5mdC, blood cadmium and lead, and total urinary arsenic in 174 children with DD and 88 healthy children. Global DNA methylation levels are expressed as the ratio 5mdC/2’-dexyguanosine (dG), called 5mdC (%). In our findings, elevated levels of blood lead and total urinary arsenic were significantly associated with DD risk among preschoolers. Furthermore, high 5mdC (%) was related with reduced risk of DD, with an odds ratio (OR) and 95% confidence interval (CI) of 0.14 (0.06 – 0.32). A notable multiplicative interaction was observed between low 5mdC (%) and elevated blood lead levels to increase OR of DD, with OR and 95% CI was 9.51 (4.18 – 21.64). The findings provide evidence of the combined effects of reduced 5mdC (%) and high blood lead concentrations, increasing the OR of DD.https://doi.org/10.1186/s12940-024-01151-65-methyl-2’-deoxycytidineArsenicLeadDevelopmental delayPreschool children |
| spellingShingle | Yuu-Hueih Hsu Chih-Yin Wu Hui-Ling Lee Ru-Lan Hsieh Ya-Li Huang Horng-Sheng Shiue Ying-Chin Lin Mei-Chieh Chen Yu-Mei Hsueh Combined effects of global DNA methylation, blood lead and total urinary arsenic levels on developmental delay in preschool children Environmental Health 5-methyl-2’-deoxycytidine Arsenic Lead Developmental delay Preschool children |
| title | Combined effects of global DNA methylation, blood lead and total urinary arsenic levels on developmental delay in preschool children |
| title_full | Combined effects of global DNA methylation, blood lead and total urinary arsenic levels on developmental delay in preschool children |
| title_fullStr | Combined effects of global DNA methylation, blood lead and total urinary arsenic levels on developmental delay in preschool children |
| title_full_unstemmed | Combined effects of global DNA methylation, blood lead and total urinary arsenic levels on developmental delay in preschool children |
| title_short | Combined effects of global DNA methylation, blood lead and total urinary arsenic levels on developmental delay in preschool children |
| title_sort | combined effects of global dna methylation blood lead and total urinary arsenic levels on developmental delay in preschool children |
| topic | 5-methyl-2’-deoxycytidine Arsenic Lead Developmental delay Preschool children |
| url | https://doi.org/10.1186/s12940-024-01151-6 |
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