The Expanding Role for Retinoid Signaling in Heart Development
The importance of retinoid signaling during cardiac development has long been appreciated, but recently has become a rapidly expanding field of research. Experiments performed over 50 years ago showed that too much or too little maternal intake of vitamin A proved detrimental for embryos, resulting...
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2008.39 |
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| _version_ | 1832551393159806976 |
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| author | Loretta L. Hoover Elizabeth G. Burton Bonnie A. Brooks Steven W. Kubalak |
| author_facet | Loretta L. Hoover Elizabeth G. Burton Bonnie A. Brooks Steven W. Kubalak |
| author_sort | Loretta L. Hoover |
| collection | DOAJ |
| description | The importance of retinoid signaling during cardiac development has long been appreciated, but recently has become a rapidly expanding field of research. Experiments performed over 50 years ago showed that too much or too little maternal intake of vitamin A proved detrimental for embryos, resulting in a cadre of predictable cardiac developmental defects. Germline and conditional knockout mice have revealed which molecular players in the vitamin A signaling cascade are potentially responsible for regulating specific developmental events, and many of these molecules have been temporally and spatially characterized. It is evident that intact and controlled retinoid signaling is necessary for each stage of cardiac development to proceed normally, including cardiac lineage determination, heart tube formation, looping, epicardium formation, ventricular maturation, chamber and outflow tract septation, and coronary arteriogenesis. This review summarizes many of the significant milestones in this field and particular attention is given to recently uncovered cross-talk between retinoid signaling and other developmentally significant pathways. It is our hope that this review of the role of retinoid signaling during formation, remodeling, and maturation of the developing heart will serve as a tool for future discoveries. |
| format | Article |
| id | doaj-art-508b630048ae414aab642c31694015c8 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-508b630048ae414aab642c31694015c82025-02-03T06:01:34ZengWileyThe Scientific World Journal1537-744X2008-01-01819421110.1100/tsw.2008.39The Expanding Role for Retinoid Signaling in Heart DevelopmentLoretta L. Hoover0Elizabeth G. Burton1Bonnie A. Brooks2Steven W. Kubalak3Department of Cell Biology and Anatomy, Cardiovascular Developmental Biology Center, Medical University of South Carolina, Charleston, SC, USADepartment of Cell Biology and Anatomy, Cardiovascular Developmental Biology Center, Medical University of South Carolina, Charleston, SC, USADepartment of Cell Biology and Anatomy, Cardiovascular Developmental Biology Center, Medical University of South Carolina, Charleston, SC, USADepartment of Cell Biology and Anatomy, Cardiovascular Developmental Biology Center, Medical University of South Carolina, Charleston, SC, USAThe importance of retinoid signaling during cardiac development has long been appreciated, but recently has become a rapidly expanding field of research. Experiments performed over 50 years ago showed that too much or too little maternal intake of vitamin A proved detrimental for embryos, resulting in a cadre of predictable cardiac developmental defects. Germline and conditional knockout mice have revealed which molecular players in the vitamin A signaling cascade are potentially responsible for regulating specific developmental events, and many of these molecules have been temporally and spatially characterized. It is evident that intact and controlled retinoid signaling is necessary for each stage of cardiac development to proceed normally, including cardiac lineage determination, heart tube formation, looping, epicardium formation, ventricular maturation, chamber and outflow tract septation, and coronary arteriogenesis. This review summarizes many of the significant milestones in this field and particular attention is given to recently uncovered cross-talk between retinoid signaling and other developmentally significant pathways. It is our hope that this review of the role of retinoid signaling during formation, remodeling, and maturation of the developing heart will serve as a tool for future discoveries.http://dx.doi.org/10.1100/tsw.2008.39 |
| spellingShingle | Loretta L. Hoover Elizabeth G. Burton Bonnie A. Brooks Steven W. Kubalak The Expanding Role for Retinoid Signaling in Heart Development The Scientific World Journal |
| title | The Expanding Role for Retinoid Signaling in Heart Development |
| title_full | The Expanding Role for Retinoid Signaling in Heart Development |
| title_fullStr | The Expanding Role for Retinoid Signaling in Heart Development |
| title_full_unstemmed | The Expanding Role for Retinoid Signaling in Heart Development |
| title_short | The Expanding Role for Retinoid Signaling in Heart Development |
| title_sort | expanding role for retinoid signaling in heart development |
| url | http://dx.doi.org/10.1100/tsw.2008.39 |
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