Prevalence and Types of Coinfections in Sleeping Sickness Patients in Kenya (2000/2009)
The occurrence of coinfections in human African trypanosomiasis (HAT) patients was investigated using a retrospective data of hospital records at the National Sleeping Sickness Referral Hospital in Alupe, Kenya. A total of 31 patients, 19 males and 12 females, were diagnosed with HAT between the yea...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Tropical Medicine |
| Online Access: | http://dx.doi.org/10.1155/2011/248914 |
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| author | J. M. Kagira N. Maina J. Njenga S. M. Karanja S. M. Karori J. M. Ngotho |
| author_facet | J. M. Kagira N. Maina J. Njenga S. M. Karanja S. M. Karori J. M. Ngotho |
| author_sort | J. M. Kagira |
| collection | DOAJ |
| description | The occurrence of coinfections in human African trypanosomiasis (HAT) patients was investigated using a retrospective data of hospital records at the National Sleeping Sickness Referral Hospital in Alupe, Kenya. A total of 31 patients, 19 males and 12 females, were diagnosed with HAT between the years 2000 and 2009. The observed co-infections included malaria (100%), helminthosis (64.5%), typhoid (22.5%), urinary tract infections (16.1%), HIV (12.9%), and tuberculosis (3.2%). The species of helminthes observed included Ancylostoma duodenale (38.7%), Ascaris lumbricoides (45.7%), Strongyloides stercoralis (9.7%), and Taenia spp. (3.2%). The patients were also infected with Entamoeba spp. (32.3%) and Trichomonas hominis (22.6%) protozoan parasites. The main clinical signs observed at the point of admission included headache (74.2%), fever (48.4%), sleep disorders (45.2%), and general body pain (41.9%). The HAT patients were treated with suramin (early stage, 9/31) and melarsoprol (late stage, 22/31). In conclusion, the study has shown that HAT patients have multiple co-infections which may influence the disease pathogenesis and complicate management of HAT. |
| format | Article |
| id | doaj-art-5081c680fa6e4f2398a6f88dbdd98431 |
| institution | Kabale University |
| issn | 1687-9686 1687-9694 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Tropical Medicine |
| spelling | doaj-art-5081c680fa6e4f2398a6f88dbdd984312025-02-03T01:31:13ZengWileyJournal of Tropical Medicine1687-96861687-96942011-01-01201110.1155/2011/248914248914Prevalence and Types of Coinfections in Sleeping Sickness Patients in Kenya (2000/2009)J. M. Kagira0N. Maina1J. Njenga2S. M. Karanja3S. M. Karori4J. M. Ngotho5Department of Tropical Infectious Diseases, Institute of Primate Research, P.O. Box 24481, Nairobi 00502, KenyaDepartment of Biochemistry, Jomo Kenyatta University of Agriculture and Technology, P.O. Box 62000, Nairobi 00200, KenyaNational Sleeping Sickness Referral Hospital, KARI-TRC Alupe, P.O. Box 399, Busia, KenyaDepartment of Biochemistry, Jomo Kenyatta University of Agriculture and Technology, P.O. Box 62000, Nairobi 00200, KenyaDepartment of Biochemistry and Molecular Biology, Egerton University, P.O. Box 536, Egerton 20115, KenyaDepartment of Tropical Infectious Diseases, Institute of Primate Research, P.O. Box 24481, Nairobi 00502, KenyaThe occurrence of coinfections in human African trypanosomiasis (HAT) patients was investigated using a retrospective data of hospital records at the National Sleeping Sickness Referral Hospital in Alupe, Kenya. A total of 31 patients, 19 males and 12 females, were diagnosed with HAT between the years 2000 and 2009. The observed co-infections included malaria (100%), helminthosis (64.5%), typhoid (22.5%), urinary tract infections (16.1%), HIV (12.9%), and tuberculosis (3.2%). The species of helminthes observed included Ancylostoma duodenale (38.7%), Ascaris lumbricoides (45.7%), Strongyloides stercoralis (9.7%), and Taenia spp. (3.2%). The patients were also infected with Entamoeba spp. (32.3%) and Trichomonas hominis (22.6%) protozoan parasites. The main clinical signs observed at the point of admission included headache (74.2%), fever (48.4%), sleep disorders (45.2%), and general body pain (41.9%). The HAT patients were treated with suramin (early stage, 9/31) and melarsoprol (late stage, 22/31). In conclusion, the study has shown that HAT patients have multiple co-infections which may influence the disease pathogenesis and complicate management of HAT.http://dx.doi.org/10.1155/2011/248914 |
| spellingShingle | J. M. Kagira N. Maina J. Njenga S. M. Karanja S. M. Karori J. M. Ngotho Prevalence and Types of Coinfections in Sleeping Sickness Patients in Kenya (2000/2009) Journal of Tropical Medicine |
| title | Prevalence and Types of Coinfections in Sleeping Sickness Patients in Kenya (2000/2009) |
| title_full | Prevalence and Types of Coinfections in Sleeping Sickness Patients in Kenya (2000/2009) |
| title_fullStr | Prevalence and Types of Coinfections in Sleeping Sickness Patients in Kenya (2000/2009) |
| title_full_unstemmed | Prevalence and Types of Coinfections in Sleeping Sickness Patients in Kenya (2000/2009) |
| title_short | Prevalence and Types of Coinfections in Sleeping Sickness Patients in Kenya (2000/2009) |
| title_sort | prevalence and types of coinfections in sleeping sickness patients in kenya 2000 2009 |
| url | http://dx.doi.org/10.1155/2011/248914 |
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