Matrix stiffness drives drop like nuclear deformation and lamin A/C tension-dependent YAP nuclear localization

Matrix stiffness drives drop like nuclear deformation and lamin A/C tension-dependent YAP nuclear localization

Abstract Extracellular matrix (ECM) stiffness influences cancer cell fate by altering gene expression. Previous studies suggest that stiffness-induced nuclear deformation may regulate gene expression through YAP nuclear localization. We investigated the role of the nuclear lamina in this process. We...

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Main Authors: Ting-Ching Wang, Samere Abolghasemzade, Brendan P. McKee, Ishita Singh, Kavya Pendyala, Mohammad Mohajeri, Hailee Patel, Aakansha Shaji, Anna L. Kersey, Kajol Harsh, Simran Kaur, Christina R. Dollahon, Sasanka Chukkapalli, Pushkar P. Lele, Daniel E. Conway, Akhilesh K. Gaharwar, Richard B. Dickinson, Tanmay P. Lele
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54577-4
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