Intrinsic Osteoinductivity of Porous Titanium Scaffold for Bone Tissue Engineering
Large bone defects and nonunions are serious complications that are caused by extensive trauma or tumour. As traditional therapies fail to repair these critical-sized defects, tissue engineering scaffolds can be used to regenerate the damaged tissue. Highly porous titanium scaffolds, produced by sel...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | International Journal of Biomaterials |
| Online Access: | http://dx.doi.org/10.1155/2017/5093063 |
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| author | Maryam Tamaddon Sorousheh Samizadeh Ling Wang Gordon Blunn Chaozong Liu |
| author_facet | Maryam Tamaddon Sorousheh Samizadeh Ling Wang Gordon Blunn Chaozong Liu |
| author_sort | Maryam Tamaddon |
| collection | DOAJ |
| description | Large bone defects and nonunions are serious complications that are caused by extensive trauma or tumour. As traditional therapies fail to repair these critical-sized defects, tissue engineering scaffolds can be used to regenerate the damaged tissue. Highly porous titanium scaffolds, produced by selective laser sintering with mechanical properties in range of trabecular bone (compressive strength 35 MPa and modulus 73 MPa), can be used in these orthopaedic applications, if a stable mechanical fixation is provided. Hydroxyapatite coatings are generally considered essential and/or beneficial for bone formation; however, debonding of the coatings is one of the main concerns. We hypothesised that the titanium scaffolds have an intrinsic potential to induce bone formation without the need for a hydroxyapatite coating. In this paper, titanium scaffolds coated with hydroxyapatite using electrochemical method were fabricated and osteoinductivity of coated and noncoated scaffolds was compared in vitro. Alizarin Red quantification confirmed osteogenesis independent of coating. Bone formation and ingrowth into the titanium scaffolds were evaluated in sheep stifle joints. The examinations after 3 months revealed 70% bone ingrowth into the scaffold confirming its osteoinductive capacity. It is shown that the developed titanium scaffold has an intrinsic capacity for bone formation and is a suitable scaffold for bone tissue engineering. |
| format | Article |
| id | doaj-art-5077ec1d77a94467b32874d3018d6346 |
| institution | Kabale University |
| issn | 1687-8787 1687-8795 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomaterials |
| spelling | doaj-art-5077ec1d77a94467b32874d3018d63462025-02-03T01:31:33ZengWileyInternational Journal of Biomaterials1687-87871687-87952017-01-01201710.1155/2017/50930635093063Intrinsic Osteoinductivity of Porous Titanium Scaffold for Bone Tissue EngineeringMaryam Tamaddon0Sorousheh Samizadeh1Ling Wang2Gordon Blunn3Chaozong Liu4Institute of Orthopaedic & Musculoskeletal Science, University College London, Royal National Orthopaedic Hospital, Stanmore HA7 4LP, UKInstitute of Orthopaedic & Musculoskeletal Science, University College London, Royal National Orthopaedic Hospital, Stanmore HA7 4LP, UKState Key Laboratory for Manufacturing System Engineering, Xi’an Jiaotong University, Xi’an, Shanxi Province 710049, ChinaInstitute of Orthopaedic & Musculoskeletal Science, University College London, Royal National Orthopaedic Hospital, Stanmore HA7 4LP, UKInstitute of Orthopaedic & Musculoskeletal Science, University College London, Royal National Orthopaedic Hospital, Stanmore HA7 4LP, UKLarge bone defects and nonunions are serious complications that are caused by extensive trauma or tumour. As traditional therapies fail to repair these critical-sized defects, tissue engineering scaffolds can be used to regenerate the damaged tissue. Highly porous titanium scaffolds, produced by selective laser sintering with mechanical properties in range of trabecular bone (compressive strength 35 MPa and modulus 73 MPa), can be used in these orthopaedic applications, if a stable mechanical fixation is provided. Hydroxyapatite coatings are generally considered essential and/or beneficial for bone formation; however, debonding of the coatings is one of the main concerns. We hypothesised that the titanium scaffolds have an intrinsic potential to induce bone formation without the need for a hydroxyapatite coating. In this paper, titanium scaffolds coated with hydroxyapatite using electrochemical method were fabricated and osteoinductivity of coated and noncoated scaffolds was compared in vitro. Alizarin Red quantification confirmed osteogenesis independent of coating. Bone formation and ingrowth into the titanium scaffolds were evaluated in sheep stifle joints. The examinations after 3 months revealed 70% bone ingrowth into the scaffold confirming its osteoinductive capacity. It is shown that the developed titanium scaffold has an intrinsic capacity for bone formation and is a suitable scaffold for bone tissue engineering.http://dx.doi.org/10.1155/2017/5093063 |
| spellingShingle | Maryam Tamaddon Sorousheh Samizadeh Ling Wang Gordon Blunn Chaozong Liu Intrinsic Osteoinductivity of Porous Titanium Scaffold for Bone Tissue Engineering International Journal of Biomaterials |
| title | Intrinsic Osteoinductivity of Porous Titanium Scaffold for Bone Tissue Engineering |
| title_full | Intrinsic Osteoinductivity of Porous Titanium Scaffold for Bone Tissue Engineering |
| title_fullStr | Intrinsic Osteoinductivity of Porous Titanium Scaffold for Bone Tissue Engineering |
| title_full_unstemmed | Intrinsic Osteoinductivity of Porous Titanium Scaffold for Bone Tissue Engineering |
| title_short | Intrinsic Osteoinductivity of Porous Titanium Scaffold for Bone Tissue Engineering |
| title_sort | intrinsic osteoinductivity of porous titanium scaffold for bone tissue engineering |
| url | http://dx.doi.org/10.1155/2017/5093063 |
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