The Relationship between Routine Blood Parameters and the Prognosis of COVID-19 Patients in the Emergency Department
The aim of this study is to investigate the routine blood parameters of COVID-19 patients at the time of admission to the emergency department and their relationship with the severity of the disease and prognosis. A total of 500 patients, who were diagnosed with severe COVID-19 and hospitalized in t...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Emergency Medicine International |
| Online Access: | http://dx.doi.org/10.1155/2021/7489675 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832562804713848832 |
|---|---|
| author | Birsen Ertekin Mehmet Yortanlı Ozan Özelbaykal Ali Doğru A. Sadık Girişgin Tarık Acar |
| author_facet | Birsen Ertekin Mehmet Yortanlı Ozan Özelbaykal Ali Doğru A. Sadık Girişgin Tarık Acar |
| author_sort | Birsen Ertekin |
| collection | DOAJ |
| description | The aim of this study is to investigate the routine blood parameters of COVID-19 patients at the time of admission to the emergency department and their relationship with the severity of the disease and prognosis. A total of 500 patients, who were diagnosed with severe COVID-19 and hospitalized in the intensive care unit between 01.04.2020 and 01.02.2021 in the emergency department of a pandemic hospital, were retrospectively analyzed. Demographic, clinical, and laboratory data of the patients were obtained from the hospital registry system. Neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) were calculated using neutrophil, lymphocyte, monocyte, and platelet counts. These patients were divided into two groups: survivors and deceased. All parameters obtained from routine blood analysis were statistically compared between these two groups. While 280 out of 500 patients survived, 220 died. Of all patients, the mean age was 67 years and 51.8% were males. There was a significant difference between the two groups in terms of age, gender, length of hospital stay, need for mechanical ventilation, white blood cell, neutrophil, lymphocyte, monocyte, eosinophil, platelet counts, CRP, ferritin, procalcitonin values, NLR, MLR, and PLR (p<0.001 for all). While NLR alone and MLR + NEU and NLR + PLR + MLR combinations had the highest AUC values (0.930, 0.947, and 0.939, respectively), MLR and PLR alone showed the lowest AUC values (0.875 and 0.797, respectively). The sensitivity, specificity, positive predictive values (PPVs), and negative predictive values (NPVs) in the prediction of death according to the cutoff values of the parameters have been determined. A significant correlation was determined between age, NLR, MLR, and PLR and duration of hospital stay (p<0.001 for all). Routine blood parameters and NLR, MLR, and PLR can assist emergency physicians to identify the severity and early prognosis of COVID-19 patients. |
| format | Article |
| id | doaj-art-50650832e2c240fcac680e72182d8a13 |
| institution | Kabale University |
| issn | 2090-2859 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Emergency Medicine International |
| spelling | doaj-art-50650832e2c240fcac680e72182d8a132025-02-03T01:21:45ZengWileyEmergency Medicine International2090-28592021-01-01202110.1155/2021/7489675The Relationship between Routine Blood Parameters and the Prognosis of COVID-19 Patients in the Emergency DepartmentBirsen Ertekin0Mehmet Yortanlı1Ozan Özelbaykal2Ali Doğru3A. Sadık Girişgin4Tarık Acar5Department of EmergencyDepartment of EmergencyDepartment of EmergencyDepartment of EmergencyDepartment of EmergencyDepartment of EmergencyThe aim of this study is to investigate the routine blood parameters of COVID-19 patients at the time of admission to the emergency department and their relationship with the severity of the disease and prognosis. A total of 500 patients, who were diagnosed with severe COVID-19 and hospitalized in the intensive care unit between 01.04.2020 and 01.02.2021 in the emergency department of a pandemic hospital, were retrospectively analyzed. Demographic, clinical, and laboratory data of the patients were obtained from the hospital registry system. Neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) were calculated using neutrophil, lymphocyte, monocyte, and platelet counts. These patients were divided into two groups: survivors and deceased. All parameters obtained from routine blood analysis were statistically compared between these two groups. While 280 out of 500 patients survived, 220 died. Of all patients, the mean age was 67 years and 51.8% were males. There was a significant difference between the two groups in terms of age, gender, length of hospital stay, need for mechanical ventilation, white blood cell, neutrophil, lymphocyte, monocyte, eosinophil, platelet counts, CRP, ferritin, procalcitonin values, NLR, MLR, and PLR (p<0.001 for all). While NLR alone and MLR + NEU and NLR + PLR + MLR combinations had the highest AUC values (0.930, 0.947, and 0.939, respectively), MLR and PLR alone showed the lowest AUC values (0.875 and 0.797, respectively). The sensitivity, specificity, positive predictive values (PPVs), and negative predictive values (NPVs) in the prediction of death according to the cutoff values of the parameters have been determined. A significant correlation was determined between age, NLR, MLR, and PLR and duration of hospital stay (p<0.001 for all). Routine blood parameters and NLR, MLR, and PLR can assist emergency physicians to identify the severity and early prognosis of COVID-19 patients.http://dx.doi.org/10.1155/2021/7489675 |
| spellingShingle | Birsen Ertekin Mehmet Yortanlı Ozan Özelbaykal Ali Doğru A. Sadık Girişgin Tarık Acar The Relationship between Routine Blood Parameters and the Prognosis of COVID-19 Patients in the Emergency Department Emergency Medicine International |
| title | The Relationship between Routine Blood Parameters and the Prognosis of COVID-19 Patients in the Emergency Department |
| title_full | The Relationship between Routine Blood Parameters and the Prognosis of COVID-19 Patients in the Emergency Department |
| title_fullStr | The Relationship between Routine Blood Parameters and the Prognosis of COVID-19 Patients in the Emergency Department |
| title_full_unstemmed | The Relationship between Routine Blood Parameters and the Prognosis of COVID-19 Patients in the Emergency Department |
| title_short | The Relationship between Routine Blood Parameters and the Prognosis of COVID-19 Patients in the Emergency Department |
| title_sort | relationship between routine blood parameters and the prognosis of covid 19 patients in the emergency department |
| url | http://dx.doi.org/10.1155/2021/7489675 |
| work_keys_str_mv | AT birsenertekin therelationshipbetweenroutinebloodparametersandtheprognosisofcovid19patientsintheemergencydepartment AT mehmetyortanlı therelationshipbetweenroutinebloodparametersandtheprognosisofcovid19patientsintheemergencydepartment AT ozanozelbaykal therelationshipbetweenroutinebloodparametersandtheprognosisofcovid19patientsintheemergencydepartment AT alidogru therelationshipbetweenroutinebloodparametersandtheprognosisofcovid19patientsintheemergencydepartment AT asadıkgirisgin therelationshipbetweenroutinebloodparametersandtheprognosisofcovid19patientsintheemergencydepartment AT tarıkacar therelationshipbetweenroutinebloodparametersandtheprognosisofcovid19patientsintheemergencydepartment AT birsenertekin relationshipbetweenroutinebloodparametersandtheprognosisofcovid19patientsintheemergencydepartment AT mehmetyortanlı relationshipbetweenroutinebloodparametersandtheprognosisofcovid19patientsintheemergencydepartment AT ozanozelbaykal relationshipbetweenroutinebloodparametersandtheprognosisofcovid19patientsintheemergencydepartment AT alidogru relationshipbetweenroutinebloodparametersandtheprognosisofcovid19patientsintheemergencydepartment AT asadıkgirisgin relationshipbetweenroutinebloodparametersandtheprognosisofcovid19patientsintheemergencydepartment AT tarıkacar relationshipbetweenroutinebloodparametersandtheprognosisofcovid19patientsintheemergencydepartment |