Prospective study of factors associated with asthma attack recurrence (ATTACK) in children from three Ecuadorian cities during COVID-19: a study protocol
Introduction Asthma is a growing health problem in children in marginalised urban settings in low-income and middle-income countries. Asthma attacks are an important cause of emergency care attendance and long-term morbidity. We designed a prospective study, the Asthma Attacks study, to identify fac...
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BMJ Publishing Group
2022-06-01
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| Online Access: | https://bmjopen.bmj.com/content/12/6/e056295.full |
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| author | Cristina Ardura-Garcia Max Bachmann Alejandro Rodriguez Philip Cooper Michael Richard Perkin Irina Chis Ster Natalia Cristina Romero Martha E Chico Alvaro Cruz Diana Morillo Santiago Mena-Bucheli Angélica Ochoa Claudia Rodas Augusto Maldonado Karen Arteaga Jessica Alchundia Karla Solorzano Camila Figueiredo |
| author_facet | Cristina Ardura-Garcia Max Bachmann Alejandro Rodriguez Philip Cooper Michael Richard Perkin Irina Chis Ster Natalia Cristina Romero Martha E Chico Alvaro Cruz Diana Morillo Santiago Mena-Bucheli Angélica Ochoa Claudia Rodas Augusto Maldonado Karen Arteaga Jessica Alchundia Karla Solorzano Camila Figueiredo |
| author_sort | Cristina Ardura-Garcia |
| collection | DOAJ |
| description | Introduction Asthma is a growing health problem in children in marginalised urban settings in low-income and middle-income countries. Asthma attacks are an important cause of emergency care attendance and long-term morbidity. We designed a prospective study, the Asthma Attacks study, to identify factors associated with recurrence of asthma attacks (or exacerbations) among children and adolescents attending emergency care in three Ecuadorian cities.Methods and analysis Prospective cohort study designed to identify risk factors associated with recurrence of asthma attacks in 450 children and adolescents aged 5–17 years attending emergency care in public hospitals in three Ecuadorian cities (Quito, Cuenca and Portoviejo). The primary outcome will be rate of asthma attack recurrence during up to 12 months of follow-up. Data are being collected at baseline and during follow-up by questionnaire: sociodemographic data, asthma history and management (baseline only); recurrence of asthma symptoms and attacks (monthly); economic costs of asthma to family; Asthma Control Test; Pediatric Asthma Quality of life Questionnaire; and Newcastle Asthma Knowledge Questionnaire (baseline only). In addition, the following are being measured at baseline and during follow-up: lung function and reversibility by spirometry before and after salbutamol; fractional exhaled nitric oxide (FeNO); and presence of IgG antibodies to SARS-CoV-2 in blood. Recruitment started in 2019 but because of severe disruption to emergency services caused by the COVID-19 pandemic, eligibility criteria were modified to include asthmatic children with uncontrolled symptoms and registered with collaborating hospitals. Data will be analysed using logistic regression and survival analyses.Ethics and dissemination Ethical approval was obtained from the Hospital General Docente de Calderon (CEISH-HGDC 2019-001) and Ecuadorian Ministry of Public Health (MSP-CGDES-2021-0041-O N° 096-2021). The study results will be disseminated through presentations at conferences and to key stakeholder groups including policy-makers, postgraduate theses, peer-review publications and a study website. Participants gave informed consent to participate in the study before taking part. |
| format | Article |
| id | doaj-art-505e3ea004a54e598aaaf0a428d3e0af |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-505e3ea004a54e598aaaf0a428d3e0af2025-01-27T22:35:14ZengBMJ Publishing GroupBMJ Open2044-60552022-06-0112610.1136/bmjopen-2021-056295Prospective study of factors associated with asthma attack recurrence (ATTACK) in children from three Ecuadorian cities during COVID-19: a study protocolCristina Ardura-Garcia0Max Bachmann1Alejandro Rodriguez2Philip Cooper3Michael Richard Perkin4Irina Chis Ster5Natalia Cristina Romero6Martha E Chico7Alvaro Cruz8Diana Morillo9Santiago Mena-Bucheli10Angélica Ochoa11Claudia Rodas12Augusto Maldonado13Karen Arteaga14Jessica Alchundia15Karla Solorzano16Camila Figueiredo17Institute of Social and Preventive Medicine, University of Bern, Bern, SwitzerlandNorwich Medical School, University of East Anglia, University of East Anglia, Norwich, UKEscuela de Medicina, Universidad Internacional del Ecuador, Quito, EcuadorSchool of Medicine, International University of Ecuador, Quito, EcuadorPopulation Health Research Institute, St George`s University of London, London, England, UKInstitute of Infection and Immunity, St George’s University of London, London, UKSchool of Medicine, International University of Ecuador, Quito, EcuadorEscuela de Medicina, Universidad Internacional del Ecuador, Quito, EcuadorNúcleo de Excelência em Asma, Universidade Federal da Bahia, Salvador, BrazilEscuela de Medicina, Universidad Internacional del Ecuador, Quito, EcuadorEscuela de Medicina, Universidad Internacional del Ecuador, Quito, EcuadorDepartment of Biosciences, Universidad de Cuenca, Cuenca, EcuadorFacultad de Medicina, Universidad de Azuay, Cuenca, EcuadorSchool of Medicine, Universidad San Francisco de Quito, Quito, EcuadorEmergency Department, Hospital Verdi Cevallos Balda, Portoviejo, EcuadorPediatric Pneumology, Hospital de Especialidades Portoviejo, Portoviejo, EcuadorPediatric Pneumology, Hospital de Especialidades Portoviejo, Portoviejo, EcuadorInstituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Bahia, BrazilIntroduction Asthma is a growing health problem in children in marginalised urban settings in low-income and middle-income countries. Asthma attacks are an important cause of emergency care attendance and long-term morbidity. We designed a prospective study, the Asthma Attacks study, to identify factors associated with recurrence of asthma attacks (or exacerbations) among children and adolescents attending emergency care in three Ecuadorian cities.Methods and analysis Prospective cohort study designed to identify risk factors associated with recurrence of asthma attacks in 450 children and adolescents aged 5–17 years attending emergency care in public hospitals in three Ecuadorian cities (Quito, Cuenca and Portoviejo). The primary outcome will be rate of asthma attack recurrence during up to 12 months of follow-up. Data are being collected at baseline and during follow-up by questionnaire: sociodemographic data, asthma history and management (baseline only); recurrence of asthma symptoms and attacks (monthly); economic costs of asthma to family; Asthma Control Test; Pediatric Asthma Quality of life Questionnaire; and Newcastle Asthma Knowledge Questionnaire (baseline only). In addition, the following are being measured at baseline and during follow-up: lung function and reversibility by spirometry before and after salbutamol; fractional exhaled nitric oxide (FeNO); and presence of IgG antibodies to SARS-CoV-2 in blood. Recruitment started in 2019 but because of severe disruption to emergency services caused by the COVID-19 pandemic, eligibility criteria were modified to include asthmatic children with uncontrolled symptoms and registered with collaborating hospitals. Data will be analysed using logistic regression and survival analyses.Ethics and dissemination Ethical approval was obtained from the Hospital General Docente de Calderon (CEISH-HGDC 2019-001) and Ecuadorian Ministry of Public Health (MSP-CGDES-2021-0041-O N° 096-2021). The study results will be disseminated through presentations at conferences and to key stakeholder groups including policy-makers, postgraduate theses, peer-review publications and a study website. Participants gave informed consent to participate in the study before taking part.https://bmjopen.bmj.com/content/12/6/e056295.full |
| spellingShingle | Cristina Ardura-Garcia Max Bachmann Alejandro Rodriguez Philip Cooper Michael Richard Perkin Irina Chis Ster Natalia Cristina Romero Martha E Chico Alvaro Cruz Diana Morillo Santiago Mena-Bucheli Angélica Ochoa Claudia Rodas Augusto Maldonado Karen Arteaga Jessica Alchundia Karla Solorzano Camila Figueiredo Prospective study of factors associated with asthma attack recurrence (ATTACK) in children from three Ecuadorian cities during COVID-19: a study protocol BMJ Open |
| title | Prospective study of factors associated with asthma attack recurrence (ATTACK) in children from three Ecuadorian cities during COVID-19: a study protocol |
| title_full | Prospective study of factors associated with asthma attack recurrence (ATTACK) in children from three Ecuadorian cities during COVID-19: a study protocol |
| title_fullStr | Prospective study of factors associated with asthma attack recurrence (ATTACK) in children from three Ecuadorian cities during COVID-19: a study protocol |
| title_full_unstemmed | Prospective study of factors associated with asthma attack recurrence (ATTACK) in children from three Ecuadorian cities during COVID-19: a study protocol |
| title_short | Prospective study of factors associated with asthma attack recurrence (ATTACK) in children from three Ecuadorian cities during COVID-19: a study protocol |
| title_sort | prospective study of factors associated with asthma attack recurrence attack in children from three ecuadorian cities during covid 19 a study protocol |
| url | https://bmjopen.bmj.com/content/12/6/e056295.full |
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