The Role of IL-33 in Gut Mucosal Inflammation
Interleukin (IL)-33 is a recently identified cytokine belonging to the IL-1 family that is widely expressed throughout the body and has the ability to induce Th2 immune responses. In addition, IL-33 plays a key role in promoting host defenses against parasites through the expansion of a novel popula...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/608187 |
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| _version_ | 1832545366094905344 |
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| author | Luca Pastorelli Carlo De Salvo Maurizio Vecchi Theresa T. Pizarro |
| author_facet | Luca Pastorelli Carlo De Salvo Maurizio Vecchi Theresa T. Pizarro |
| author_sort | Luca Pastorelli |
| collection | DOAJ |
| description | Interleukin (IL)-33 is a recently identified cytokine belonging to the IL-1 family that is widely expressed throughout the body and has the ability to induce Th2 immune responses. In addition, IL-33 plays a key role in promoting host defenses against parasites through the expansion of a novel population of innate lymphoid cells. In recent years, a growing body of evidence has shown that the proinflammatory properties displayed by IL-33 are detrimental in several experimental models of inflammation; in others, however, IL-33 appears to have protective functions. In 2010, four different research groups consistently described the upregulation of IL-33 in patients with inflammatory bowel disease (IBD). Animal models of IBD were subsequently utilized in order to mechanistically determine the precise role of IL-33 in chronic intestinal inflammation, without, however, reaching conclusive evidence demonstrating whether IL-33 is pathogenic or protective. Indeed, data generated from these studies suggest that IL-33 may possess dichotomous functions, enhancing inflammatory responses on one hand and promoting epithelial integrity on the other. This review focuses on the available data regarding IL-33/ST2 in the physiological and inflammatory states of the gut in order to speculate on the possible roles of this novel IL-1 family member in intestinal inflammation. |
| format | Article |
| id | doaj-art-505484a1cb6a4aacaf081c26354aa3e6 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-505484a1cb6a4aacaf081c26354aa3e62025-02-03T07:26:04ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/608187608187The Role of IL-33 in Gut Mucosal InflammationLuca Pastorelli0Carlo De Salvo1Maurizio Vecchi2Theresa T. Pizarro3Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USADepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USAGastroenterology and Gastrointestinal Endoscopy Unit, IRCCS Policlinico San Donato, 20097 San Donato Milanese, ItalyDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USAInterleukin (IL)-33 is a recently identified cytokine belonging to the IL-1 family that is widely expressed throughout the body and has the ability to induce Th2 immune responses. In addition, IL-33 plays a key role in promoting host defenses against parasites through the expansion of a novel population of innate lymphoid cells. In recent years, a growing body of evidence has shown that the proinflammatory properties displayed by IL-33 are detrimental in several experimental models of inflammation; in others, however, IL-33 appears to have protective functions. In 2010, four different research groups consistently described the upregulation of IL-33 in patients with inflammatory bowel disease (IBD). Animal models of IBD were subsequently utilized in order to mechanistically determine the precise role of IL-33 in chronic intestinal inflammation, without, however, reaching conclusive evidence demonstrating whether IL-33 is pathogenic or protective. Indeed, data generated from these studies suggest that IL-33 may possess dichotomous functions, enhancing inflammatory responses on one hand and promoting epithelial integrity on the other. This review focuses on the available data regarding IL-33/ST2 in the physiological and inflammatory states of the gut in order to speculate on the possible roles of this novel IL-1 family member in intestinal inflammation.http://dx.doi.org/10.1155/2013/608187 |
| spellingShingle | Luca Pastorelli Carlo De Salvo Maurizio Vecchi Theresa T. Pizarro The Role of IL-33 in Gut Mucosal Inflammation Mediators of Inflammation |
| title | The Role of IL-33 in Gut Mucosal Inflammation |
| title_full | The Role of IL-33 in Gut Mucosal Inflammation |
| title_fullStr | The Role of IL-33 in Gut Mucosal Inflammation |
| title_full_unstemmed | The Role of IL-33 in Gut Mucosal Inflammation |
| title_short | The Role of IL-33 in Gut Mucosal Inflammation |
| title_sort | role of il 33 in gut mucosal inflammation |
| url | http://dx.doi.org/10.1155/2013/608187 |
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