Facile one-pot reduction of β-nitrostyrenes to phenethylamines using sodium borohydride and copper(II) chloride
Phenethylamines and phenylisopropylamines of scientific relevance can be prepared with a NaBH4/CuCl2 system in 10 to 30 minutes via reduction of substituted β-nitrostyrenes. This one-pot procedure allows the quick isolation of substituted β-nitrostyrene scaffolds with 62–83% yield under mild conditi...
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2025-01-01
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| Series: | Beilstein Journal of Organic Chemistry |
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| Online Access: | https://doi.org/10.3762/bjoc.21.4 |
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| _version_ | 1832544815764471808 |
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| author | Laura D’Andrea Simon Jademyr |
| author_facet | Laura D’Andrea Simon Jademyr |
| author_sort | Laura D’Andrea |
| collection | DOAJ |
| description | Phenethylamines and phenylisopropylamines of scientific relevance can be prepared with a NaBH4/CuCl2 system in 10 to 30 minutes via reduction of substituted β-nitrostyrenes. This one-pot procedure allows the quick isolation of substituted β-nitrostyrene scaffolds with 62–83% yield under mild conditions, without the need for special precautions, inert atmosphere, and time-consuming purification techniques. |
| format | Article |
| id | doaj-art-505192cc07864817be0d575f110f375a |
| institution | Kabale University |
| issn | 1860-5397 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Organic Chemistry |
| spelling | doaj-art-505192cc07864817be0d575f110f375a2025-02-03T09:10:17ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972025-01-01211394610.3762/bjoc.21.41860-5397-21-4Facile one-pot reduction of β-nitrostyrenes to phenethylamines using sodium borohydride and copper(II) chlorideLaura D’Andrea0Simon Jademyr1Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 København Ø, Denmark Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 København Ø, Denmark Phenethylamines and phenylisopropylamines of scientific relevance can be prepared with a NaBH4/CuCl2 system in 10 to 30 minutes via reduction of substituted β-nitrostyrenes. This one-pot procedure allows the quick isolation of substituted β-nitrostyrene scaffolds with 62–83% yield under mild conditions, without the need for special precautions, inert atmosphere, and time-consuming purification techniques.https://doi.org/10.3762/bjoc.21.42c-xcucl2nabh4β-nitrostyrenephenethylamine |
| spellingShingle | Laura D’Andrea Simon Jademyr Facile one-pot reduction of β-nitrostyrenes to phenethylamines using sodium borohydride and copper(II) chloride Beilstein Journal of Organic Chemistry 2c-x cucl2 nabh4 β-nitrostyrene phenethylamine |
| title | Facile one-pot reduction of β-nitrostyrenes to phenethylamines using sodium borohydride and copper(II) chloride |
| title_full | Facile one-pot reduction of β-nitrostyrenes to phenethylamines using sodium borohydride and copper(II) chloride |
| title_fullStr | Facile one-pot reduction of β-nitrostyrenes to phenethylamines using sodium borohydride and copper(II) chloride |
| title_full_unstemmed | Facile one-pot reduction of β-nitrostyrenes to phenethylamines using sodium borohydride and copper(II) chloride |
| title_short | Facile one-pot reduction of β-nitrostyrenes to phenethylamines using sodium borohydride and copper(II) chloride |
| title_sort | facile one pot reduction of β nitrostyrenes to phenethylamines using sodium borohydride and copper ii chloride |
| topic | 2c-x cucl2 nabh4 β-nitrostyrene phenethylamine |
| url | https://doi.org/10.3762/bjoc.21.4 |
| work_keys_str_mv | AT lauradandrea facileonepotreductionofbnitrostyrenestophenethylaminesusingsodiumborohydrideandcopperiichloride AT simonjademyr facileonepotreductionofbnitrostyrenestophenethylaminesusingsodiumborohydrideandcopperiichloride |