Gadolinium(III) Complexes with N-Alkyl-N-methylglucamine Surfactants Incorporated into Liposomes as Potential MRI Contrast Agents
Complexes of gadolinium(III) with N-octanoyl-N-methylglucamine (L8) and N-decanoyl-N-methylglucamine (L10) with 1 : 2 stoichiometry were synthesized and characterized by elemental analysis, electrospray ionization-tandem mass spectrometry (ESI-MS), infrared (IR) spectroscopy, and molar conductivity...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2015/942147 |
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| author | Simone Rodrigues Silva Érica Correia Duarte Guilherme Santos Ramos Flávio Vinícius Crizóstomo Kock Fabiana Diuk Andrade Frédéric Frézard Luiz Alberto Colnago Cynthia Demicheli |
| author_facet | Simone Rodrigues Silva Érica Correia Duarte Guilherme Santos Ramos Flávio Vinícius Crizóstomo Kock Fabiana Diuk Andrade Frédéric Frézard Luiz Alberto Colnago Cynthia Demicheli |
| author_sort | Simone Rodrigues Silva |
| collection | DOAJ |
| description | Complexes of gadolinium(III) with N-octanoyl-N-methylglucamine (L8) and N-decanoyl-N-methylglucamine (L10) with 1 : 2 stoichiometry were synthesized and characterized by elemental analysis, electrospray ionization-tandem mass spectrometry (ESI-MS), infrared (IR) spectroscopy, and molar conductivity measurements. The transverse (r2) and longitudinal (r1) relaxivity protons were measured at 20 MHz and compared with those of the commercial contrasts. These complexes were incorporated in liposomes, resulting in the increase of the vesicle zeta potential. Both the free and liposome-incorporated gadolinium complexes showed high relaxation effectiveness, compared to commercial contrast agent gadopentetate dimeglumine (Magnevist). The high relaxivity of these complexes was attributed to the molecular rotation that occurs more slowly, because of the elevated molecular weight and incorporation in liposomes. The results establish that these paramagnetic complexes are highly potent contrast agents, making them excellent candidates for various applications in molecular MR imaging. |
| format | Article |
| id | doaj-art-504f0d3bc3d841ca93d97efa129e9851 |
| institution | Kabale University |
| issn | 1565-3633 1687-479X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-504f0d3bc3d841ca93d97efa129e98512025-02-03T05:45:19ZengWileyBioinorganic Chemistry and Applications1565-36331687-479X2015-01-01201510.1155/2015/942147942147Gadolinium(III) Complexes with N-Alkyl-N-methylglucamine Surfactants Incorporated into Liposomes as Potential MRI Contrast AgentsSimone Rodrigues Silva0Érica Correia Duarte1Guilherme Santos Ramos2Flávio Vinícius Crizóstomo Kock3Fabiana Diuk Andrade4Frédéric Frézard5Luiz Alberto Colnago6Cynthia Demicheli7Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, MG, BrazilDepartamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, MG, BrazilDepartamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, MG, BrazilEmbrapa Instrumentação, Empresa Brasileira de Pesquisa Agropecuária, 13560-970 São Carlos, SP, BrazilEmbrapa Instrumentação, Empresa Brasileira de Pesquisa Agropecuária, 13560-970 São Carlos, SP, BrazilDepartamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, MG, BrazilEmbrapa Instrumentação, Empresa Brasileira de Pesquisa Agropecuária, 13560-970 São Carlos, SP, BrazilDepartamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, MG, BrazilComplexes of gadolinium(III) with N-octanoyl-N-methylglucamine (L8) and N-decanoyl-N-methylglucamine (L10) with 1 : 2 stoichiometry were synthesized and characterized by elemental analysis, electrospray ionization-tandem mass spectrometry (ESI-MS), infrared (IR) spectroscopy, and molar conductivity measurements. The transverse (r2) and longitudinal (r1) relaxivity protons were measured at 20 MHz and compared with those of the commercial contrasts. These complexes were incorporated in liposomes, resulting in the increase of the vesicle zeta potential. Both the free and liposome-incorporated gadolinium complexes showed high relaxation effectiveness, compared to commercial contrast agent gadopentetate dimeglumine (Magnevist). The high relaxivity of these complexes was attributed to the molecular rotation that occurs more slowly, because of the elevated molecular weight and incorporation in liposomes. The results establish that these paramagnetic complexes are highly potent contrast agents, making them excellent candidates for various applications in molecular MR imaging.http://dx.doi.org/10.1155/2015/942147 |
| spellingShingle | Simone Rodrigues Silva Érica Correia Duarte Guilherme Santos Ramos Flávio Vinícius Crizóstomo Kock Fabiana Diuk Andrade Frédéric Frézard Luiz Alberto Colnago Cynthia Demicheli Gadolinium(III) Complexes with N-Alkyl-N-methylglucamine Surfactants Incorporated into Liposomes as Potential MRI Contrast Agents Bioinorganic Chemistry and Applications |
| title | Gadolinium(III) Complexes with N-Alkyl-N-methylglucamine Surfactants Incorporated into Liposomes as Potential MRI Contrast Agents |
| title_full | Gadolinium(III) Complexes with N-Alkyl-N-methylglucamine Surfactants Incorporated into Liposomes as Potential MRI Contrast Agents |
| title_fullStr | Gadolinium(III) Complexes with N-Alkyl-N-methylglucamine Surfactants Incorporated into Liposomes as Potential MRI Contrast Agents |
| title_full_unstemmed | Gadolinium(III) Complexes with N-Alkyl-N-methylglucamine Surfactants Incorporated into Liposomes as Potential MRI Contrast Agents |
| title_short | Gadolinium(III) Complexes with N-Alkyl-N-methylglucamine Surfactants Incorporated into Liposomes as Potential MRI Contrast Agents |
| title_sort | gadolinium iii complexes with n alkyl n methylglucamine surfactants incorporated into liposomes as potential mri contrast agents |
| url | http://dx.doi.org/10.1155/2015/942147 |
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