Second-Generation Recombinant Hemoglobin Molecules Do Not Stimulate Sphincter of Oddi, Gallbladder, or Duodenal Motility in the Australian Brush-Tailed Possum
BACKGROUND: Several studies have investigated the effects of hemoglobin-based oxygen carriers on gastrointestinal motility. Diaspirin cross-linked hemoglobin reduces sphincter of Oddi trans-sphincteric flow and increases duodenal motility in the Australian brush-tailed possum, effects attributed to...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2004-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2004/497284 |
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| _version_ | 1832564324055384064 |
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| author | Shunichi Takahata Hiroyuki Konomi Ann C Schloithe James Toouli Gino TP Saccone |
| author_facet | Shunichi Takahata Hiroyuki Konomi Ann C Schloithe James Toouli Gino TP Saccone |
| author_sort | Shunichi Takahata |
| collection | DOAJ |
| description | BACKGROUND: Several studies have investigated the effects of hemoglobin-based oxygen carriers on gastrointestinal motility. Diaspirin cross-linked hemoglobin reduces sphincter of Oddi trans-sphincteric flow and increases duodenal motility in the Australian brush-tailed possum, effects attributed to nitric oxide (NO) scavenging. Recently, second-generation recombinant hemoglobin molecules with reduced NO scavenging ability have been developed. |
| format | Article |
| id | doaj-art-503d79500cb842ac9f2ebdb1174414d5 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2004-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-503d79500cb842ac9f2ebdb1174414d52025-02-03T01:11:15ZengWileyCanadian Journal of Gastroenterology0835-79002004-01-0118744144810.1155/2004/497284Second-Generation Recombinant Hemoglobin Molecules Do Not Stimulate Sphincter of Oddi, Gallbladder, or Duodenal Motility in the Australian Brush-Tailed PossumShunichi TakahataHiroyuki KonomiAnn C SchloitheJames ToouliGino TP SacconeBACKGROUND: Several studies have investigated the effects of hemoglobin-based oxygen carriers on gastrointestinal motility. Diaspirin cross-linked hemoglobin reduces sphincter of Oddi trans-sphincteric flow and increases duodenal motility in the Australian brush-tailed possum, effects attributed to nitric oxide (NO) scavenging. Recently, second-generation recombinant hemoglobin molecules with reduced NO scavenging ability have been developed.http://dx.doi.org/10.1155/2004/497284 |
| spellingShingle | Shunichi Takahata Hiroyuki Konomi Ann C Schloithe James Toouli Gino TP Saccone Second-Generation Recombinant Hemoglobin Molecules Do Not Stimulate Sphincter of Oddi, Gallbladder, or Duodenal Motility in the Australian Brush-Tailed Possum Canadian Journal of Gastroenterology |
| title | Second-Generation Recombinant Hemoglobin Molecules Do Not Stimulate Sphincter of Oddi, Gallbladder, or Duodenal Motility in the Australian Brush-Tailed Possum |
| title_full | Second-Generation Recombinant Hemoglobin Molecules Do Not Stimulate Sphincter of Oddi, Gallbladder, or Duodenal Motility in the Australian Brush-Tailed Possum |
| title_fullStr | Second-Generation Recombinant Hemoglobin Molecules Do Not Stimulate Sphincter of Oddi, Gallbladder, or Duodenal Motility in the Australian Brush-Tailed Possum |
| title_full_unstemmed | Second-Generation Recombinant Hemoglobin Molecules Do Not Stimulate Sphincter of Oddi, Gallbladder, or Duodenal Motility in the Australian Brush-Tailed Possum |
| title_short | Second-Generation Recombinant Hemoglobin Molecules Do Not Stimulate Sphincter of Oddi, Gallbladder, or Duodenal Motility in the Australian Brush-Tailed Possum |
| title_sort | second generation recombinant hemoglobin molecules do not stimulate sphincter of oddi gallbladder or duodenal motility in the australian brush tailed possum |
| url | http://dx.doi.org/10.1155/2004/497284 |
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