The diagnostic performance of indocyanine green for the sentinel node biopsy in prostate cancer: A systematic review and meta-analysis
Objective: Almost 15% of prostate cancer (PCa) patients were found to have lymph node metastases (LNMs), which are associated with higher risk of biochemical recurrence. Using indocyanine green (ICG) for the sentinel node biopsy (SNB) before surgery was proposed to detect LNMs in PCa patients. Howev...
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Elsevier
2025-01-01
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| Series: | Asian Journal of Urology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214388224000912 |
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| author | Siyang Ma Jianxuan Sun Jinzhou Xu Ye An Mengyao Xu Chenqian Liu Sihan Zhang Lintao Miao Xingyu Zhong Na Zeng Haodong He Shaogang Wang Qidong Xia |
| author_facet | Siyang Ma Jianxuan Sun Jinzhou Xu Ye An Mengyao Xu Chenqian Liu Sihan Zhang Lintao Miao Xingyu Zhong Na Zeng Haodong He Shaogang Wang Qidong Xia |
| author_sort | Siyang Ma |
| collection | DOAJ |
| description | Objective: Almost 15% of prostate cancer (PCa) patients were found to have lymph node metastases (LNMs), which are associated with higher risk of biochemical recurrence. Using indocyanine green (ICG) for the sentinel node biopsy (SNB) before surgery was proposed to detect LNMs in PCa patients. However, its diagnostic performance still remains controversial. This study aimed to investigate the diagnostic performance of ICG for the SNB in PCa. Methods: This systematic review and meta-analysis has been reported in line with the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. The protocol has been registered in the International Prospective Register of Systematic Reviews database, and the register number is CRD42023421911. Four bibliographic databases were searched, i.e., PubMed, EMBASE, Cochrane Library, and Web of Science, to retrieve articles studying the diagnostic performance of ICG for the SNB in PCa from the inception to Sep 9, 2023. We calculated the pooled sensitivity, specificity, likelihood ratios, diagnostic odds ratios and their 95% confidence intervals (CIs). Subgroup analyses and meta-regression analyses were also conducted. Results: A total of 17 articles from databases are enrolled in this study. Using lymph node-based data, our results showed that the pooled sensitivity and specificity of applying ICG alone in PCa were 71% (95% CI 52%–85%) and 68% (95% CI 64%–72%), respectively. The pooled sensitivity and specificity of applying ICG-technetium-99m-nanocolloid in PCa were 49% (95% CI 39%–59%) and 69% (95% CI 67%–71%), respectively. Conclusion: The efficacy of using ICG or ICG-technetium-99m-nanocolloid for the SNB in PCa is relatively unsatisfactory. ICG cannot yet substitute extended pelvic lymph node dissection for detecting LNMs accurately. More research or novel tracers are needed to achieve the goal of precise surgery. |
| format | Article |
| id | doaj-art-50371b03679d4bc8a3ae44269dcf041d |
| institution | Kabale University |
| issn | 2214-3882 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Urology |
| spelling | doaj-art-50371b03679d4bc8a3ae44269dcf041d2025-01-30T05:14:16ZengElsevierAsian Journal of Urology2214-38822025-01-01121114The diagnostic performance of indocyanine green for the sentinel node biopsy in prostate cancer: A systematic review and meta-analysisSiyang Ma0Jianxuan Sun1Jinzhou Xu2Ye An3Mengyao Xu4Chenqian Liu5Sihan Zhang6Lintao Miao7Xingyu Zhong8Na Zeng9Haodong He10Shaogang Wang11Qidong Xia12Department and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaCorresponding author.; Department and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaCorresponding author.; Department and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaObjective: Almost 15% of prostate cancer (PCa) patients were found to have lymph node metastases (LNMs), which are associated with higher risk of biochemical recurrence. Using indocyanine green (ICG) for the sentinel node biopsy (SNB) before surgery was proposed to detect LNMs in PCa patients. However, its diagnostic performance still remains controversial. This study aimed to investigate the diagnostic performance of ICG for the SNB in PCa. Methods: This systematic review and meta-analysis has been reported in line with the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. The protocol has been registered in the International Prospective Register of Systematic Reviews database, and the register number is CRD42023421911. Four bibliographic databases were searched, i.e., PubMed, EMBASE, Cochrane Library, and Web of Science, to retrieve articles studying the diagnostic performance of ICG for the SNB in PCa from the inception to Sep 9, 2023. We calculated the pooled sensitivity, specificity, likelihood ratios, diagnostic odds ratios and their 95% confidence intervals (CIs). Subgroup analyses and meta-regression analyses were also conducted. Results: A total of 17 articles from databases are enrolled in this study. Using lymph node-based data, our results showed that the pooled sensitivity and specificity of applying ICG alone in PCa were 71% (95% CI 52%–85%) and 68% (95% CI 64%–72%), respectively. The pooled sensitivity and specificity of applying ICG-technetium-99m-nanocolloid in PCa were 49% (95% CI 39%–59%) and 69% (95% CI 67%–71%), respectively. Conclusion: The efficacy of using ICG or ICG-technetium-99m-nanocolloid for the SNB in PCa is relatively unsatisfactory. ICG cannot yet substitute extended pelvic lymph node dissection for detecting LNMs accurately. More research or novel tracers are needed to achieve the goal of precise surgery.http://www.sciencedirect.com/science/article/pii/S2214388224000912Indocyanine greenProstate cancerSentinel node biopsyLymph node metastasisMeta-analysisSystematic review |
| spellingShingle | Siyang Ma Jianxuan Sun Jinzhou Xu Ye An Mengyao Xu Chenqian Liu Sihan Zhang Lintao Miao Xingyu Zhong Na Zeng Haodong He Shaogang Wang Qidong Xia The diagnostic performance of indocyanine green for the sentinel node biopsy in prostate cancer: A systematic review and meta-analysis Asian Journal of Urology Indocyanine green Prostate cancer Sentinel node biopsy Lymph node metastasis Meta-analysis Systematic review |
| title | The diagnostic performance of indocyanine green for the sentinel node biopsy in prostate cancer: A systematic review and meta-analysis |
| title_full | The diagnostic performance of indocyanine green for the sentinel node biopsy in prostate cancer: A systematic review and meta-analysis |
| title_fullStr | The diagnostic performance of indocyanine green for the sentinel node biopsy in prostate cancer: A systematic review and meta-analysis |
| title_full_unstemmed | The diagnostic performance of indocyanine green for the sentinel node biopsy in prostate cancer: A systematic review and meta-analysis |
| title_short | The diagnostic performance of indocyanine green for the sentinel node biopsy in prostate cancer: A systematic review and meta-analysis |
| title_sort | diagnostic performance of indocyanine green for the sentinel node biopsy in prostate cancer a systematic review and meta analysis |
| topic | Indocyanine green Prostate cancer Sentinel node biopsy Lymph node metastasis Meta-analysis Systematic review |
| url | http://www.sciencedirect.com/science/article/pii/S2214388224000912 |
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