Intrinsic p53 activation restricts gammaherpesvirus driven germinal center B cell expansion during latency establishment

Intrinsic p53 activation restricts gammaherpesvirus driven germinal center B cell expansion during latency establishment

Abstract Gammaherpesviruses are DNA tumor viruses that establish lifelong latent infections in lymphocytes. For viruses such as Epstein-Barr virus and murine gammaherpesvirus 68, this is accomplished through a viral gene-expression program that promotes cellular proliferation and differentiation, es...

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Main Authors: Shana M. Owens, Jeffrey M. Sifford, Gang Li, Steven J. Murdock, Eduardo Salinas, Darby Oldenburg, Debopam Ghosh, Jason S. Stumhofer, Intawat Nookaew, Mark Manzano, J. Craig Forrest
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56247-5
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https://doi.org/10.1038/s41467-025-56247-5

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