Clinical and Imaging Characteristics of Smear Negative Pulmonary Tuberculosis Patients: A Comparative Study
Background. Prevalence surveys in Ethiopia indicate smear negative pulmonary tuberculosis (SNPTB) taking the major share of the overall TB burden. It has also been a diagnostic dilemma worldwide leading to diagnostic delays and difficulty in monitoring treatment outcomes. This study determines and c...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Pulmonary Medicine |
| Online Access: | http://dx.doi.org/10.1155/2024/2182088 |
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| author | Alem Alemayehu Liya Wassie Sebsib Neway Samuel Ayele Abraham Assefa Kidist Bobosha Beyene Petros Rawleigh Howe |
| author_facet | Alem Alemayehu Liya Wassie Sebsib Neway Samuel Ayele Abraham Assefa Kidist Bobosha Beyene Petros Rawleigh Howe |
| author_sort | Alem Alemayehu |
| collection | DOAJ |
| description | Background. Prevalence surveys in Ethiopia indicate smear negative pulmonary tuberculosis (SNPTB) taking the major share of the overall TB burden. It has also been a diagnostic dilemma worldwide leading to diagnostic delays and difficulty in monitoring treatment outcomes. This study determines and compares the clinical and imaging findings in SNPTB and smear positive PTB (SPPTB). Methodology. A case-control study was conducted on 313 PTB (173 SNPTB) patients. Data and sputum samples were collected from consented patients. Smear microscopy, GeneXpert, and culture analyses were performed on sputum samples. Data were analyzed using Stata version 17; a P value < 0.05 was considered statistically significant. Results. Of the 173 SNPTB patients, 42% were culture positive with discordances between test results reported by health facilities and Armauer Hansen Research Institute laboratory using concentrated smear microscopy. A previous history of TB and fewer cavitary lesions were significantly associated with SNPTB. Conclusions. Though overall clinical presentations of SNPTB patients resemble those seen in SPPTB patients, a prior history of TB was strongly associated with SNPTB. Subject to further investigations, the relatively higher discrepancies seen in TB diagnoses reflect the posed diagnostic challenges in SNPTB patients, as a higher proportion of these patients are also seen in Ethiopia. |
| format | Article |
| id | doaj-art-5033453bd74e4a268eb46d0cecf3500e |
| institution | Kabale University |
| issn | 2090-1844 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Medicine |
| spelling | doaj-art-5033453bd74e4a268eb46d0cecf3500e2025-02-03T06:14:54ZengWileyPulmonary Medicine2090-18442024-01-01202410.1155/2024/2182088Clinical and Imaging Characteristics of Smear Negative Pulmonary Tuberculosis Patients: A Comparative StudyAlem Alemayehu0Liya Wassie1Sebsib Neway2Samuel Ayele3Abraham Assefa4Kidist Bobosha5Beyene Petros6Rawleigh Howe7College of Natural and Computational SciencesArmauer Hansen Research Institute (AHRI)Armauer Hansen Research Institute (AHRI)Armauer Hansen Research Institute (AHRI)Armauer Hansen Research Institute (AHRI)Armauer Hansen Research Institute (AHRI)College of Natural and Computational SciencesArmauer Hansen Research Institute (AHRI)Background. Prevalence surveys in Ethiopia indicate smear negative pulmonary tuberculosis (SNPTB) taking the major share of the overall TB burden. It has also been a diagnostic dilemma worldwide leading to diagnostic delays and difficulty in monitoring treatment outcomes. This study determines and compares the clinical and imaging findings in SNPTB and smear positive PTB (SPPTB). Methodology. A case-control study was conducted on 313 PTB (173 SNPTB) patients. Data and sputum samples were collected from consented patients. Smear microscopy, GeneXpert, and culture analyses were performed on sputum samples. Data were analyzed using Stata version 17; a P value < 0.05 was considered statistically significant. Results. Of the 173 SNPTB patients, 42% were culture positive with discordances between test results reported by health facilities and Armauer Hansen Research Institute laboratory using concentrated smear microscopy. A previous history of TB and fewer cavitary lesions were significantly associated with SNPTB. Conclusions. Though overall clinical presentations of SNPTB patients resemble those seen in SPPTB patients, a prior history of TB was strongly associated with SNPTB. Subject to further investigations, the relatively higher discrepancies seen in TB diagnoses reflect the posed diagnostic challenges in SNPTB patients, as a higher proportion of these patients are also seen in Ethiopia.http://dx.doi.org/10.1155/2024/2182088 |
| spellingShingle | Alem Alemayehu Liya Wassie Sebsib Neway Samuel Ayele Abraham Assefa Kidist Bobosha Beyene Petros Rawleigh Howe Clinical and Imaging Characteristics of Smear Negative Pulmonary Tuberculosis Patients: A Comparative Study Pulmonary Medicine |
| title | Clinical and Imaging Characteristics of Smear Negative Pulmonary Tuberculosis Patients: A Comparative Study |
| title_full | Clinical and Imaging Characteristics of Smear Negative Pulmonary Tuberculosis Patients: A Comparative Study |
| title_fullStr | Clinical and Imaging Characteristics of Smear Negative Pulmonary Tuberculosis Patients: A Comparative Study |
| title_full_unstemmed | Clinical and Imaging Characteristics of Smear Negative Pulmonary Tuberculosis Patients: A Comparative Study |
| title_short | Clinical and Imaging Characteristics of Smear Negative Pulmonary Tuberculosis Patients: A Comparative Study |
| title_sort | clinical and imaging characteristics of smear negative pulmonary tuberculosis patients a comparative study |
| url | http://dx.doi.org/10.1155/2024/2182088 |
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