Coffee and tea consumption and dementia risk: The role of sex and vascular comorbidities
Background: Coffee and tea consumption has been linked to dementia. However, it remained unknown how sex and vascular risk factors modify the association. We aimed to investigate the association of coffee and tea consumption with dementia and whether sex and vascular comorbidities modified the assoc...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Journal of the Formosan Medical Association |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664624002183 |
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| author | Kuan-Chu Hou Yen-Ching Chen Ta-Fu Chen Yu Sun Li-Li Wen Ping-Keung Yip Yi-Min Chu Jeng-Min Chiou Jen-Hau Chen |
| author_facet | Kuan-Chu Hou Yen-Ching Chen Ta-Fu Chen Yu Sun Li-Li Wen Ping-Keung Yip Yi-Min Chu Jeng-Min Chiou Jen-Hau Chen |
| author_sort | Kuan-Chu Hou |
| collection | DOAJ |
| description | Background: Coffee and tea consumption has been linked to dementia. However, it remained unknown how sex and vascular risk factors modify the association. We aimed to investigate the association of coffee and tea consumption with dementia and whether sex and vascular comorbidities modified the association. Methods: We included 278 elderly patients with Alzheimer's disease (AD) and 102 patients with vascular dementia (VaD) from three hospitals; controls (N = 468) were recruited during the same period. We collected the frequency and amount of coffee and tea consumption and the presence of vascular comorbidities. The multinomial logistic regression model was utilized to evaluate the association of coffee and tea consumption with dementia, stratified by sex and vascular comorbidities. Results: Different combinations and quantities of coffee and tea consumption protected against AD and VaD. Consumption of ≥3 cups of coffee or tea per day was protective against AD [adjusted odds ratio (aOR) = 0.42; 95% confidence interval (CI) = 0.22–0.78)] and VaD (aOR = 0.42; 95% CI = 0.19–0.94). Stratified analyses showed that the protective effects of a higher quantity of coffee and tea against AD were more pronounced among females and individuals with hypertension. Consumption of either coffee or tea was associated with a decreased risk of VaD among diabetic participants (aOR = 0.23; 95% CI = 0.06–0.98). Hyperlipidemia modified the association of coffee or tea consumption on the risk of AD and VaD (both Pinteraction < 0.01). Conclusion: The risk of AD and VaD was lower with increased consumption of coffee and tea; the impact differed by sex and vascular comorbidities including hypertension, hyperlipidemia, and diabetes. |
| format | Article |
| id | doaj-art-5026ef155b6c40f4ade0e2c6be66f722 |
| institution | Kabale University |
| issn | 0929-6646 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj-art-5026ef155b6c40f4ade0e2c6be66f7222025-02-02T05:26:46ZengElsevierJournal of the Formosan Medical Association0929-66462025-02-011242178185Coffee and tea consumption and dementia risk: The role of sex and vascular comorbiditiesKuan-Chu Hou0Yen-Ching Chen1Ta-Fu Chen2Yu Sun3Li-Li Wen4Ping-Keung Yip5Yi-Min Chu6Jeng-Min Chiou7Jen-Hau Chen8Department of Medicine, National Taiwan University, Taipei, TaiwanInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan; Department of Public Health, College of Public Health, National Taiwan University, Taipei, Taiwan; Corresponding author. Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, No. 17, Xu-Zhou Road, Taipei, 10055, Taiwan.Department of Neurology, National Taiwan University Hospital, Taipei, TaiwanDepartment of Neurology, En Chu Kong Hospital, Taipei, TaiwanDepartment of Laboratory Medicine, En Chu Kong Hospital, Taipei, TaiwanCenter of Neurological Medicine, Cardinal Tien Hospital, Taipei, Taiwan; School of Medicine, Fu-Jen Catholic University, New Taipei City, TaiwanDepartment of Laboratory Medicine, Cardinal Tien Hospital, Taipei, TaiwanInstitute of Statistical Science, Academia Sinica, Taipei, TaiwanDepartment of Geriatrics and Gerontology, National Taiwan University Hospital, Taipei, Taiwan; Department of Internal Medicine, College of Medicine, National Taiwan University, Taiwan; Corresponding author. Department of Geriatrics and Gerontology, National Taiwan University Hospital, No. 1, Changde Street, Taipei, 10048, Taiwan.Background: Coffee and tea consumption has been linked to dementia. However, it remained unknown how sex and vascular risk factors modify the association. We aimed to investigate the association of coffee and tea consumption with dementia and whether sex and vascular comorbidities modified the association. Methods: We included 278 elderly patients with Alzheimer's disease (AD) and 102 patients with vascular dementia (VaD) from three hospitals; controls (N = 468) were recruited during the same period. We collected the frequency and amount of coffee and tea consumption and the presence of vascular comorbidities. The multinomial logistic regression model was utilized to evaluate the association of coffee and tea consumption with dementia, stratified by sex and vascular comorbidities. Results: Different combinations and quantities of coffee and tea consumption protected against AD and VaD. Consumption of ≥3 cups of coffee or tea per day was protective against AD [adjusted odds ratio (aOR) = 0.42; 95% confidence interval (CI) = 0.22–0.78)] and VaD (aOR = 0.42; 95% CI = 0.19–0.94). Stratified analyses showed that the protective effects of a higher quantity of coffee and tea against AD were more pronounced among females and individuals with hypertension. Consumption of either coffee or tea was associated with a decreased risk of VaD among diabetic participants (aOR = 0.23; 95% CI = 0.06–0.98). Hyperlipidemia modified the association of coffee or tea consumption on the risk of AD and VaD (both Pinteraction < 0.01). Conclusion: The risk of AD and VaD was lower with increased consumption of coffee and tea; the impact differed by sex and vascular comorbidities including hypertension, hyperlipidemia, and diabetes.http://www.sciencedirect.com/science/article/pii/S0929664624002183Alzheimer's diseaseCoffeeTeaVascular dementia |
| spellingShingle | Kuan-Chu Hou Yen-Ching Chen Ta-Fu Chen Yu Sun Li-Li Wen Ping-Keung Yip Yi-Min Chu Jeng-Min Chiou Jen-Hau Chen Coffee and tea consumption and dementia risk: The role of sex and vascular comorbidities Journal of the Formosan Medical Association Alzheimer's disease Coffee Tea Vascular dementia |
| title | Coffee and tea consumption and dementia risk: The role of sex and vascular comorbidities |
| title_full | Coffee and tea consumption and dementia risk: The role of sex and vascular comorbidities |
| title_fullStr | Coffee and tea consumption and dementia risk: The role of sex and vascular comorbidities |
| title_full_unstemmed | Coffee and tea consumption and dementia risk: The role of sex and vascular comorbidities |
| title_short | Coffee and tea consumption and dementia risk: The role of sex and vascular comorbidities |
| title_sort | coffee and tea consumption and dementia risk the role of sex and vascular comorbidities |
| topic | Alzheimer's disease Coffee Tea Vascular dementia |
| url | http://www.sciencedirect.com/science/article/pii/S0929664624002183 |
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