The Effect of Stereochemistry on Sodium Ion Complexation in Nucleoside-Metallacarborane Conjugates
Conjugates of purine and pyrimidine nucleosides: thymidine and 2-deoxyguanosine with cobalt-metallacarborane were studied for their sodium ion complexing properties. Formation of stable complexes of 1 : 1 stoichiometry was proved by ESI MS spectroscopy and 23Na NMR. Equilibrium constants and energi...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2010/196064 |
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| author | Agnieszka B. Olejniczak Jan Milecki Grzegorz Schroeder |
| author_facet | Agnieszka B. Olejniczak Jan Milecki Grzegorz Schroeder |
| author_sort | Agnieszka B. Olejniczak |
| collection | DOAJ |
| description | Conjugates of purine and pyrimidine nucleosides: thymidine and 2-deoxyguanosine with cobalt-metallacarborane were studied for their sodium ion complexing properties. Formation of stable complexes of 1 : 1 stoichiometry was proved by ESI MS spectroscopy and 23Na NMR. Equilibrium constants and energies of complex formation were calculated. Complexation of alkali-metals by nucleoside-metallacarborane conjugates may affect the physicochemical and biological properties of the conjugates and should be taken into consideration during biological evaluation of these types of modifications. |
| format | Article |
| id | doaj-art-5017a03f776c49e791e675db68f1a2fd |
| institution | Kabale University |
| issn | 1565-3633 1687-479X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-5017a03f776c49e791e675db68f1a2fd2025-02-03T01:02:36ZengWileyBioinorganic Chemistry and Applications1565-36331687-479X2010-01-01201010.1155/2010/196064196064The Effect of Stereochemistry on Sodium Ion Complexation in Nucleoside-Metallacarborane ConjugatesAgnieszka B. Olejniczak0Jan Milecki1Grzegorz Schroeder2Laboratory of Molecular Virology and Biological Chemistry, Institute for Medical Biology of the Polish Academy of Sciences, Lodowa 106, 93-232 Łódź, PolandFaculty of Chemistry, Adam Mickiewicz University, Grunwaldzka 6, 60-780 Poznań, PolandFaculty of Chemistry, Adam Mickiewicz University, Grunwaldzka 6, 60-780 Poznań, PolandConjugates of purine and pyrimidine nucleosides: thymidine and 2-deoxyguanosine with cobalt-metallacarborane were studied for their sodium ion complexing properties. Formation of stable complexes of 1 : 1 stoichiometry was proved by ESI MS spectroscopy and 23Na NMR. Equilibrium constants and energies of complex formation were calculated. Complexation of alkali-metals by nucleoside-metallacarborane conjugates may affect the physicochemical and biological properties of the conjugates and should be taken into consideration during biological evaluation of these types of modifications.http://dx.doi.org/10.1155/2010/196064 |
| spellingShingle | Agnieszka B. Olejniczak Jan Milecki Grzegorz Schroeder The Effect of Stereochemistry on Sodium Ion Complexation in Nucleoside-Metallacarborane Conjugates Bioinorganic Chemistry and Applications |
| title | The Effect of Stereochemistry on Sodium Ion Complexation in Nucleoside-Metallacarborane Conjugates |
| title_full | The Effect of Stereochemistry on Sodium Ion Complexation in Nucleoside-Metallacarborane Conjugates |
| title_fullStr | The Effect of Stereochemistry on Sodium Ion Complexation in Nucleoside-Metallacarborane Conjugates |
| title_full_unstemmed | The Effect of Stereochemistry on Sodium Ion Complexation in Nucleoside-Metallacarborane Conjugates |
| title_short | The Effect of Stereochemistry on Sodium Ion Complexation in Nucleoside-Metallacarborane Conjugates |
| title_sort | effect of stereochemistry on sodium ion complexation in nucleoside metallacarborane conjugates |
| url | http://dx.doi.org/10.1155/2010/196064 |
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