ACTH4 -10, Substance P, and Dizolcipine (Mk-801) Accelerate Functional Recovery After Hemilabyrinthectomy in Goldfish
In this study, we evaluated the goldfish model of hemilabyrinthectomy for investigating potential recovery-promoting drugs. In this lesion model, the unilateral removal of the labyrinth induces a postural imbalance in response to light (Dorsal Light Reflex), from which the animals can recover over t...
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| Format: | Article |
| Language: | English |
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Wiley
2000-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/NP.2000.291 |
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| author | R. Mattioli J. P. Huston R. E. Spieler |
| author_facet | R. Mattioli J. P. Huston R. E. Spieler |
| author_sort | R. Mattioli |
| collection | DOAJ |
| description | In this study, we evaluated the goldfish model
of hemilabyrinthectomy for investigating potential
recovery-promoting drugs. In this lesion model,
the unilateral removal of the labyrinth induces a
postural imbalance in response to light (Dorsal
Light Reflex), from which the animals can
recover over time. The behavioral effects of two
neuropeptides were tested–namely, of substance
P and ACTH4-10, both of which are known to
promote functional recovery in several other
lesion models. Furthermore, the effect of MK-
801, an antagonist of the glutamatergic NMDAreceptor
subtype, was tested because this
substance has also been shown to exert a
neuroprotective effect. After lesion of the right
labyrinth, the animals (n=12)
were treated intraperitoneally
daily either with vehicle (n=12),
substance P (n=11)
, ACTH4-10 (n=12)
, or MK-
801 (n=12)
. Another group (n=11)
, which served
as a non-lesion control, did not receive hemilabyrinthectomy
or systemic injections. The
lesion group, treated post-operatively with vehicle,
did not recover from the postural deviation over
the 24-d testing period. In contrast, all three test
substances accelerated the functional recovery
after unilateral labyrinthectomy. The decrease of
the dorsal light reflex persisted even after
cessation of drug treatment after 20d. The
results indicate that using the dorsal light reflex
in the model of hemilabyrinthectomy in goldfish
provides a useful approach to studying the
ability of potential new neurotrophic or neuroprotective
drugs to promote functional recovery. |
| format | Article |
| id | doaj-art-5012e8ae8e214cb284b89375e8182ab2 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2000-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-5012e8ae8e214cb284b89375e8182ab22025-02-03T05:44:22ZengWileyNeural Plasticity2090-59041687-54432000-01-017429130110.1155/NP.2000.291ACTH4 -10, Substance P, and Dizolcipine (Mk-801) Accelerate Functional Recovery After Hemilabyrinthectomy in GoldfishR. Mattioli0J. P. Huston1R. E. Spieler2Laboratory of Neuroscience, Department of Physical Therapy, Center for Biological and Health Sciences, Universidade Federal de São Carlos, BrazilInstitute of Physiological Psychology and Center for Biological and Medical Research, University of Düsseldorf, GermanyOceanographic Center, Nova Southeastern University, Dania, Florida, USAIn this study, we evaluated the goldfish model of hemilabyrinthectomy for investigating potential recovery-promoting drugs. In this lesion model, the unilateral removal of the labyrinth induces a postural imbalance in response to light (Dorsal Light Reflex), from which the animals can recover over time. The behavioral effects of two neuropeptides were tested–namely, of substance P and ACTH4-10, both of which are known to promote functional recovery in several other lesion models. Furthermore, the effect of MK- 801, an antagonist of the glutamatergic NMDAreceptor subtype, was tested because this substance has also been shown to exert a neuroprotective effect. After lesion of the right labyrinth, the animals (n=12) were treated intraperitoneally daily either with vehicle (n=12), substance P (n=11) , ACTH4-10 (n=12) , or MK- 801 (n=12) . Another group (n=11) , which served as a non-lesion control, did not receive hemilabyrinthectomy or systemic injections. The lesion group, treated post-operatively with vehicle, did not recover from the postural deviation over the 24-d testing period. In contrast, all three test substances accelerated the functional recovery after unilateral labyrinthectomy. The decrease of the dorsal light reflex persisted even after cessation of drug treatment after 20d. The results indicate that using the dorsal light reflex in the model of hemilabyrinthectomy in goldfish provides a useful approach to studying the ability of potential new neurotrophic or neuroprotective drugs to promote functional recovery.http://dx.doi.org/10.1155/NP.2000.291 |
| spellingShingle | R. Mattioli J. P. Huston R. E. Spieler ACTH4 -10, Substance P, and Dizolcipine (Mk-801) Accelerate Functional Recovery After Hemilabyrinthectomy in Goldfish Neural Plasticity |
| title | ACTH4 -10, Substance P, and Dizolcipine (Mk-801) Accelerate Functional Recovery After Hemilabyrinthectomy in Goldfish |
| title_full | ACTH4 -10, Substance P, and Dizolcipine (Mk-801) Accelerate Functional Recovery After Hemilabyrinthectomy in Goldfish |
| title_fullStr | ACTH4 -10, Substance P, and Dizolcipine (Mk-801) Accelerate Functional Recovery After Hemilabyrinthectomy in Goldfish |
| title_full_unstemmed | ACTH4 -10, Substance P, and Dizolcipine (Mk-801) Accelerate Functional Recovery After Hemilabyrinthectomy in Goldfish |
| title_short | ACTH4 -10, Substance P, and Dizolcipine (Mk-801) Accelerate Functional Recovery After Hemilabyrinthectomy in Goldfish |
| title_sort | acth4 10 substance p and dizolcipine mk 801 accelerate functional recovery after hemilabyrinthectomy in goldfish |
| url | http://dx.doi.org/10.1155/NP.2000.291 |
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