Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids, with Cranial and Caudal Extension
A 23-year-old lady presented with vertigo and imbalance in walking, blurring of vision, diplopia, and headache, in addition to numbness in the lower limbs over a period of six days. On examination patient had nystagmus, ataxia, positive Romberg test, and hyperreflexia. MRI examination of the brain a...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Case Reports in Neurological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2017/2593096 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832549510389170176 |
|---|---|
| author | Mahmood Mubasher Aseel Sukik Ahmed Hassan El Beltagi Ali Rahil |
| author_facet | Mahmood Mubasher Aseel Sukik Ahmed Hassan El Beltagi Ali Rahil |
| author_sort | Mahmood Mubasher |
| collection | DOAJ |
| description | A 23-year-old lady presented with vertigo and imbalance in walking, blurring of vision, diplopia, and headache, in addition to numbness in the lower limbs over a period of six days. On examination patient had nystagmus, ataxia, positive Romberg test, and hyperreflexia. MRI examination of the brain and spinal cord showed evidence of faint bright signal intensity foci in T2/FLAIR involving bilateral cerebral hemispheres, subcortical deep white matter, bilateral thalami, posterior pons and left brachium pontis, and basal ganglia, with small nodular enhancement that aligned along curvilinear structures; those lesions also were apparent along the spinal cord at multiple levels. The clinical and radiological features suggested CLIPPERS (chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids) syndrome. Symptoms improved dramatically with high dose oral corticosteroids. Our report addresses the radiological and clinical pattern of a case of CLIPPERS rhombencephalitis, with added superior and inferior extension to involve the brain and spinal cord, which is to emphasize the importance of raising the awareness of this disease and the combined role of radiologist and physicians for the diagnosis of this potentially treatable entity, responsive to glucocorticosteroid immunosuppression. |
| format | Article |
| id | doaj-art-4fff9e3cee8b4d2280c3e8ab3ffa36ba |
| institution | Kabale University |
| issn | 2090-6668 2090-6676 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Neurological Medicine |
| spelling | doaj-art-4fff9e3cee8b4d2280c3e8ab3ffa36ba2025-02-03T06:11:07ZengWileyCase Reports in Neurological Medicine2090-66682090-66762017-01-01201710.1155/2017/25930962593096Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids, with Cranial and Caudal ExtensionMahmood Mubasher0Aseel Sukik1Ahmed Hassan El Beltagi2Ali Rahil3Hamad Medical Corporation, Doha, QatarHamad Medical Corporation, Doha, QatarHamad Medical Corporation, Doha, QatarHamad Medical Corporation, Doha, QatarA 23-year-old lady presented with vertigo and imbalance in walking, blurring of vision, diplopia, and headache, in addition to numbness in the lower limbs over a period of six days. On examination patient had nystagmus, ataxia, positive Romberg test, and hyperreflexia. MRI examination of the brain and spinal cord showed evidence of faint bright signal intensity foci in T2/FLAIR involving bilateral cerebral hemispheres, subcortical deep white matter, bilateral thalami, posterior pons and left brachium pontis, and basal ganglia, with small nodular enhancement that aligned along curvilinear structures; those lesions also were apparent along the spinal cord at multiple levels. The clinical and radiological features suggested CLIPPERS (chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids) syndrome. Symptoms improved dramatically with high dose oral corticosteroids. Our report addresses the radiological and clinical pattern of a case of CLIPPERS rhombencephalitis, with added superior and inferior extension to involve the brain and spinal cord, which is to emphasize the importance of raising the awareness of this disease and the combined role of radiologist and physicians for the diagnosis of this potentially treatable entity, responsive to glucocorticosteroid immunosuppression.http://dx.doi.org/10.1155/2017/2593096 |
| spellingShingle | Mahmood Mubasher Aseel Sukik Ahmed Hassan El Beltagi Ali Rahil Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids, with Cranial and Caudal Extension Case Reports in Neurological Medicine |
| title | Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids, with Cranial and Caudal Extension |
| title_full | Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids, with Cranial and Caudal Extension |
| title_fullStr | Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids, with Cranial and Caudal Extension |
| title_full_unstemmed | Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids, with Cranial and Caudal Extension |
| title_short | Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids, with Cranial and Caudal Extension |
| title_sort | chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids with cranial and caudal extension |
| url | http://dx.doi.org/10.1155/2017/2593096 |
| work_keys_str_mv | AT mahmoodmubasher chroniclymphocyticinflammationwithpontineperivascularenhancementresponsivetosteroidswithcranialandcaudalextension AT aseelsukik chroniclymphocyticinflammationwithpontineperivascularenhancementresponsivetosteroidswithcranialandcaudalextension AT ahmedhassanelbeltagi chroniclymphocyticinflammationwithpontineperivascularenhancementresponsivetosteroidswithcranialandcaudalextension AT alirahil chroniclymphocyticinflammationwithpontineperivascularenhancementresponsivetosteroidswithcranialandcaudalextension |