Combined Effect of Subchondral Drilling and Hyaluronic Acid with/without Diacerein in Full-Thickness Articular Cartilage Lesion in Rabbits
The osteochondral healing potential of hyaluronic acid (HA) plus diacerein was evaluated in subchondral-drilling- (SCD-) induced fibrocartilage generation in rabbits. A full-thickness chondral defect was created along the patellar groove of both knees and then SCD was subsequently performed only in...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/310745 |
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| author | Wanwisa Suwannaloet Wiroon Laupattarakasem Peerapol Sukon Siriwan Ong-Chai Pisamai Laupattarakasem |
| author_facet | Wanwisa Suwannaloet Wiroon Laupattarakasem Peerapol Sukon Siriwan Ong-Chai Pisamai Laupattarakasem |
| author_sort | Wanwisa Suwannaloet |
| collection | DOAJ |
| description | The osteochondral healing potential of hyaluronic acid (HA) plus diacerein was evaluated in subchondral-drilling- (SCD-) induced fibrocartilage generation in rabbits. A full-thickness chondral defect was created along the patellar groove of both knees and then SCD was subsequently performed only in the left knee. A week later, the rabbits were allocated into 3 groups to receive weekly intra-articular (IA) injection for 5 weeks with normal saline solution (NSS) (group 1) or with HA (group 2 and group 3). Starting at the first IA injection, rabbits were also gavaged daily for 9 weeks with NSS (group 1 and group 2) or with diacerein (group 3). The animals were then sacrificed for evaluation. The newly formed tissue in SCD lesions showed significantly better histological grading scale and had higher content of type II collagen in HA-treated group compared to NSS control. In addition, adding oral diacerein to HA injection enhanced healing potential of HA. |
| format | Article |
| id | doaj-art-4ffbf9602f67471580bf7b4b595e138a |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-4ffbf9602f67471580bf7b4b595e138a2025-02-03T05:43:45ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/310745310745Combined Effect of Subchondral Drilling and Hyaluronic Acid with/without Diacerein in Full-Thickness Articular Cartilage Lesion in RabbitsWanwisa Suwannaloet0Wiroon Laupattarakasem1Peerapol Sukon2Siriwan Ong-Chai3Pisamai Laupattarakasem4Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, ThailandDepartment of Orthopaedics, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, ThailandDepartment of Anatomy, Faculty of Veterinary Medicine, Khon Kaen University, Khon Kaen 40002, ThailandDepartment of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, ThailandThe osteochondral healing potential of hyaluronic acid (HA) plus diacerein was evaluated in subchondral-drilling- (SCD-) induced fibrocartilage generation in rabbits. A full-thickness chondral defect was created along the patellar groove of both knees and then SCD was subsequently performed only in the left knee. A week later, the rabbits were allocated into 3 groups to receive weekly intra-articular (IA) injection for 5 weeks with normal saline solution (NSS) (group 1) or with HA (group 2 and group 3). Starting at the first IA injection, rabbits were also gavaged daily for 9 weeks with NSS (group 1 and group 2) or with diacerein (group 3). The animals were then sacrificed for evaluation. The newly formed tissue in SCD lesions showed significantly better histological grading scale and had higher content of type II collagen in HA-treated group compared to NSS control. In addition, adding oral diacerein to HA injection enhanced healing potential of HA.http://dx.doi.org/10.1100/2012/310745 |
| spellingShingle | Wanwisa Suwannaloet Wiroon Laupattarakasem Peerapol Sukon Siriwan Ong-Chai Pisamai Laupattarakasem Combined Effect of Subchondral Drilling and Hyaluronic Acid with/without Diacerein in Full-Thickness Articular Cartilage Lesion in Rabbits The Scientific World Journal |
| title | Combined Effect of Subchondral Drilling and Hyaluronic Acid with/without Diacerein in Full-Thickness Articular Cartilage Lesion in Rabbits |
| title_full | Combined Effect of Subchondral Drilling and Hyaluronic Acid with/without Diacerein in Full-Thickness Articular Cartilage Lesion in Rabbits |
| title_fullStr | Combined Effect of Subchondral Drilling and Hyaluronic Acid with/without Diacerein in Full-Thickness Articular Cartilage Lesion in Rabbits |
| title_full_unstemmed | Combined Effect of Subchondral Drilling and Hyaluronic Acid with/without Diacerein in Full-Thickness Articular Cartilage Lesion in Rabbits |
| title_short | Combined Effect of Subchondral Drilling and Hyaluronic Acid with/without Diacerein in Full-Thickness Articular Cartilage Lesion in Rabbits |
| title_sort | combined effect of subchondral drilling and hyaluronic acid with without diacerein in full thickness articular cartilage lesion in rabbits |
| url | http://dx.doi.org/10.1100/2012/310745 |
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