Influence of DPYD Genetic Polymorphisms on 5-Fluorouracil Toxicities in Patients with Colorectal Cancer: A Meta-Analysis
Our meta-analysis aggregated existing results from relevant studies to comprehensively investigate the correlations between genetic polymorphisms in dihydropyrimidine dehydrogenase (DPYD) gene and 5-fluorouracil (5-FU) toxicities in patients with colorectal cancer (CRC). The MEDLINE (1966∼2013), the...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2014/827989 |
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| author | Qiang Li Ying Liu Hong-Mei Zhang Yin-Peng Huang Tian-Yi Wang Dong-Sheng Li Hong-Zhi Sun |
| author_facet | Qiang Li Ying Liu Hong-Mei Zhang Yin-Peng Huang Tian-Yi Wang Dong-Sheng Li Hong-Zhi Sun |
| author_sort | Qiang Li |
| collection | DOAJ |
| description | Our meta-analysis aggregated existing results from relevant studies to comprehensively investigate the correlations between genetic polymorphisms in dihydropyrimidine dehydrogenase (DPYD) gene and 5-fluorouracil (5-FU) toxicities in patients with colorectal cancer (CRC). The MEDLINE (1966∼2013), the Cochrane Library Database (Issue 12, 2013), EMBASE (1980∼2013), CINAHL (1982∼2013), Web of Science (1945∼2013), and the Chinese Biomedical Database (CBM) (1982∼2013) were searched without language restrictions. Meta-analyses were conducted with the use of STATA software (Version 12.0, Stata Corporation, College Station, TX, USA). Seven clinical cohort studies with a total of 946 CRC patients met our inclusion criteria, and NOS scores of each of the included studies were ≥5. Our findings showed that DPYD genetic polymorphisms were significantly correlated with high incidences of 5-FU-related toxicity in CRC patients. SNP-stratified analysis indicated that there were remarkable connections of IVS14+1G>A, 464T>A, and 2194G>A polymorphisms with the incidence of marrow suppression in CRC patients receiving 5-FU chemotherapy. Furthermore, we found that IVS14+1G>A, 496A>G, and 2194G>A polymorphisms were correlated with the incidence of gastrointestinal reaction. Ethnicity-stratified analysis also revealed that DPYD genetic polymorphisms might contribute to the development of marrow suppression and gastrointestinal reaction among Asians, but not among Caucasians. The present meta-analysis suggests that DPYD genetic polymorphisms may be correlated with the incidence of 5-FU-related toxicity in CRC patients. |
| format | Article |
| id | doaj-art-4ff9282478f647d9ae6ac1cd94817a1b |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-4ff9282478f647d9ae6ac1cd94817a1b2025-02-03T05:45:40ZengWileyGastroenterology Research and Practice1687-61211687-630X2014-01-01201410.1155/2014/827989827989Influence of DPYD Genetic Polymorphisms on 5-Fluorouracil Toxicities in Patients with Colorectal Cancer: A Meta-AnalysisQiang Li0Ying Liu1Hong-Mei Zhang2Yin-Peng Huang3Tian-Yi Wang4Dong-Sheng Li5Hong-Zhi Sun6Department of Oncology, Jining No. 1 People’s Hospital, No. 6 Jiankang Road, Jining, Shandong 272011, ChinaDepartment of Immunology, Laiwu Municipal Center for Disease Control & Prevention, Laiwu 271100, ChinaDepartment of Oncology, Jining No. 1 People’s Hospital, No. 6 Jiankang Road, Jining, Shandong 272011, ChinaDepartment of Oncology, Jining No. 1 People’s Hospital, No. 6 Jiankang Road, Jining, Shandong 272011, ChinaDepartment of Immunology, Laiwu Municipal Center for Disease Control & Prevention, Laiwu 271100, ChinaDepartment of Oncology, Jining No. 1 People’s Hospital, No. 6 Jiankang Road, Jining, Shandong 272011, ChinaDepartment of Oncology, Jining No. 1 People’s Hospital, No. 6 Jiankang Road, Jining, Shandong 272011, ChinaOur meta-analysis aggregated existing results from relevant studies to comprehensively investigate the correlations between genetic polymorphisms in dihydropyrimidine dehydrogenase (DPYD) gene and 5-fluorouracil (5-FU) toxicities in patients with colorectal cancer (CRC). The MEDLINE (1966∼2013), the Cochrane Library Database (Issue 12, 2013), EMBASE (1980∼2013), CINAHL (1982∼2013), Web of Science (1945∼2013), and the Chinese Biomedical Database (CBM) (1982∼2013) were searched without language restrictions. Meta-analyses were conducted with the use of STATA software (Version 12.0, Stata Corporation, College Station, TX, USA). Seven clinical cohort studies with a total of 946 CRC patients met our inclusion criteria, and NOS scores of each of the included studies were ≥5. Our findings showed that DPYD genetic polymorphisms were significantly correlated with high incidences of 5-FU-related toxicity in CRC patients. SNP-stratified analysis indicated that there were remarkable connections of IVS14+1G>A, 464T>A, and 2194G>A polymorphisms with the incidence of marrow suppression in CRC patients receiving 5-FU chemotherapy. Furthermore, we found that IVS14+1G>A, 496A>G, and 2194G>A polymorphisms were correlated with the incidence of gastrointestinal reaction. Ethnicity-stratified analysis also revealed that DPYD genetic polymorphisms might contribute to the development of marrow suppression and gastrointestinal reaction among Asians, but not among Caucasians. The present meta-analysis suggests that DPYD genetic polymorphisms may be correlated with the incidence of 5-FU-related toxicity in CRC patients.http://dx.doi.org/10.1155/2014/827989 |
| spellingShingle | Qiang Li Ying Liu Hong-Mei Zhang Yin-Peng Huang Tian-Yi Wang Dong-Sheng Li Hong-Zhi Sun Influence of DPYD Genetic Polymorphisms on 5-Fluorouracil Toxicities in Patients with Colorectal Cancer: A Meta-Analysis Gastroenterology Research and Practice |
| title | Influence of DPYD Genetic Polymorphisms on 5-Fluorouracil Toxicities in Patients with Colorectal Cancer: A Meta-Analysis |
| title_full | Influence of DPYD Genetic Polymorphisms on 5-Fluorouracil Toxicities in Patients with Colorectal Cancer: A Meta-Analysis |
| title_fullStr | Influence of DPYD Genetic Polymorphisms on 5-Fluorouracil Toxicities in Patients with Colorectal Cancer: A Meta-Analysis |
| title_full_unstemmed | Influence of DPYD Genetic Polymorphisms on 5-Fluorouracil Toxicities in Patients with Colorectal Cancer: A Meta-Analysis |
| title_short | Influence of DPYD Genetic Polymorphisms on 5-Fluorouracil Toxicities in Patients with Colorectal Cancer: A Meta-Analysis |
| title_sort | influence of dpyd genetic polymorphisms on 5 fluorouracil toxicities in patients with colorectal cancer a meta analysis |
| url | http://dx.doi.org/10.1155/2014/827989 |
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