INTRAVENOUS VITAMIN C (IVC) TREATMENT OUTCOME OF COVID 19 PATIENTS ADMITTED IN HOSPITAL: A SYSTEMATIC REVIEW
Background: Coronavirus disease 2019 (COVID-19) is still becoming a problem in several countries with the emergence of new variants with the latest variant named Omicron. Studies show that patients with COVID-19 tend to have Acute Respiratory Distress Syndrome (ARDS) because of high pro-inflammatory...
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Universitas Airlangga
2023-07-01
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| Series: | Journal of Vocational Health Studies |
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| Online Access: | https://e-journal.unair.ac.id/JVHS/article/view/41564 |
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| author | Auria Ekanti Pratiwi Oki Suwarsa Achadiyani Nur Atik |
| author_facet | Auria Ekanti Pratiwi Oki Suwarsa Achadiyani Nur Atik |
| author_sort | Auria Ekanti Pratiwi |
| collection | DOAJ |
| description | Background: Coronavirus disease 2019 (COVID-19) is still becoming a problem in several countries with the emergence of new variants with the latest variant named Omicron. Studies show that patients with COVID-19 tend to have Acute Respiratory Distress Syndrome (ARDS) because of high pro-inflammatory cytokines and chemokines levels. Since its role as an antiviral agent, anti-cytokine, immunomodulator, antioxidant and has potential effect in maintaining body functions, vitamin C can be used as one of therapy. There is still arguable about giving treatment of COVID-19 patients with Intravenous Vitamin C (IVC). Previous research has not been discussed related to accelerating recovery and decreasing mortality. Purpose: To identify the impact of IVC intervention given to COVID-19 patients admitted in hospital by reviewing clinical outcomes particularly on complexity or mortality. Review: Literature information was sourced from PubMed, ScienceDirect, and Google Scholar databases through keywords to retrieve inclusion criteria published during 2019-2021. Result: We found that IVC influenced inflammatory biomarkers such as CRP, d-dimer, ferritin, and several inflammatory cytokines, mortality, length of stay, oxygenation, organ and immune system function but showed no significant difference between the control group. Conclusion: IVC treatment might be an essential adjuvant therapy in the aggravation of mild, severe, and critical COVID-19 patients, but did not understate complexity or mortality. Hence, further research and evaluation in clinical trials are needed. |
| format | Article |
| id | doaj-art-4fedcc0da48f43b1af172402b53f5c90 |
| institution | Kabale University |
| issn | 2580-7161 2580-717X |
| language | English |
| publishDate | 2023-07-01 |
| publisher | Universitas Airlangga |
| record_format | Article |
| series | Journal of Vocational Health Studies |
| spelling | doaj-art-4fedcc0da48f43b1af172402b53f5c902025-02-03T04:58:56ZengUniversitas AirlanggaJournal of Vocational Health Studies2580-71612580-717X2023-07-0171687610.20473/jvhs.V7.I1.2023.68-7639645INTRAVENOUS VITAMIN C (IVC) TREATMENT OUTCOME OF COVID 19 PATIENTS ADMITTED IN HOSPITAL: A SYSTEMATIC REVIEWAuria Ekanti Pratiwi0https://orcid.org/0000-0002-1859-3786Oki Suwarsa1https://orcid.org/0000-0003-4017-9319Achadiyani2https://orcid.org/0000-0002-9223-7296Nur Atik3https://orcid.org/0000-0001-5951-4733Department of Anti-Aging and Aesthetic Medicine, Faculty of Medicine, Padjadjaran University, Bandung, West Java, IndonesiaDepartment of Dermatovenereology, Faculty of Medicine, Universitas Padjadjaran/Hasan Sadikin Hospital, IndonesiaDepartment of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, IndonesiaDepartment of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, IndonesiaBackground: Coronavirus disease 2019 (COVID-19) is still becoming a problem in several countries with the emergence of new variants with the latest variant named Omicron. Studies show that patients with COVID-19 tend to have Acute Respiratory Distress Syndrome (ARDS) because of high pro-inflammatory cytokines and chemokines levels. Since its role as an antiviral agent, anti-cytokine, immunomodulator, antioxidant and has potential effect in maintaining body functions, vitamin C can be used as one of therapy. There is still arguable about giving treatment of COVID-19 patients with Intravenous Vitamin C (IVC). Previous research has not been discussed related to accelerating recovery and decreasing mortality. Purpose: To identify the impact of IVC intervention given to COVID-19 patients admitted in hospital by reviewing clinical outcomes particularly on complexity or mortality. Review: Literature information was sourced from PubMed, ScienceDirect, and Google Scholar databases through keywords to retrieve inclusion criteria published during 2019-2021. Result: We found that IVC influenced inflammatory biomarkers such as CRP, d-dimer, ferritin, and several inflammatory cytokines, mortality, length of stay, oxygenation, organ and immune system function but showed no significant difference between the control group. Conclusion: IVC treatment might be an essential adjuvant therapy in the aggravation of mild, severe, and critical COVID-19 patients, but did not understate complexity or mortality. Hence, further research and evaluation in clinical trials are needed.https://e-journal.unair.ac.id/JVHS/article/view/41564coronaviruscovid-19drugsintravenous vitamin c |
| spellingShingle | Auria Ekanti Pratiwi Oki Suwarsa Achadiyani Nur Atik INTRAVENOUS VITAMIN C (IVC) TREATMENT OUTCOME OF COVID 19 PATIENTS ADMITTED IN HOSPITAL: A SYSTEMATIC REVIEW Journal of Vocational Health Studies coronavirus covid-19 drugs intravenous vitamin c |
| title | INTRAVENOUS VITAMIN C (IVC) TREATMENT OUTCOME OF COVID 19 PATIENTS ADMITTED IN HOSPITAL: A SYSTEMATIC REVIEW |
| title_full | INTRAVENOUS VITAMIN C (IVC) TREATMENT OUTCOME OF COVID 19 PATIENTS ADMITTED IN HOSPITAL: A SYSTEMATIC REVIEW |
| title_fullStr | INTRAVENOUS VITAMIN C (IVC) TREATMENT OUTCOME OF COVID 19 PATIENTS ADMITTED IN HOSPITAL: A SYSTEMATIC REVIEW |
| title_full_unstemmed | INTRAVENOUS VITAMIN C (IVC) TREATMENT OUTCOME OF COVID 19 PATIENTS ADMITTED IN HOSPITAL: A SYSTEMATIC REVIEW |
| title_short | INTRAVENOUS VITAMIN C (IVC) TREATMENT OUTCOME OF COVID 19 PATIENTS ADMITTED IN HOSPITAL: A SYSTEMATIC REVIEW |
| title_sort | intravenous vitamin c ivc treatment outcome of covid 19 patients admitted in hospital a systematic review |
| topic | coronavirus covid-19 drugs intravenous vitamin c |
| url | https://e-journal.unair.ac.id/JVHS/article/view/41564 |
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