Correlation of serum tumor necrosis factor-α, interleukin-4 and soluble interleukin-2 receptor levels with radiologic and clinical manifestations in active pulmonary tuberculosis
The precise clinical manifestations of tuberculosis are likely to result from a complex interaction between the host and the pathogen. We took serum samples from a group of patients with a variety of clinical and radiological stages of pulmonary tuberculosis in order to characterize tumor necrosis f...
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| Format: | Article |
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Wiley
2003-01-01
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| Series: | Mediators of Inflammation |
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| Online Access: | http://dx.doi.org/10.1080/0962935031000096926 |
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| author | Levent Kart Hakan Buyukoglan Ishak O. Tekin Remzi Altin Zuhal Senturk Inci Gulmez Ramazan Demir Mustafa Ozesmi |
| author_facet | Levent Kart Hakan Buyukoglan Ishak O. Tekin Remzi Altin Zuhal Senturk Inci Gulmez Ramazan Demir Mustafa Ozesmi |
| author_sort | Levent Kart |
| collection | DOAJ |
| description | The precise clinical manifestations of tuberculosis are likely to result from a complex interaction between the host and the pathogen. We took serum samples from a group of patients with a variety of clinical and radiological stages of pulmonary tuberculosis in order to characterize tumor necrosis factor-α (TNF-α), interleukin-4 (IL-4) and soluble interleukin-2 receptor (sIL-2R) response. We further evaluated whether the levels of TNF-α, IL-4 and soluble IL-2R are related with each other, and also evaluated the levels of TNF-α, IL-4 and sIL-2R after anti-tuberculosis therapy and relation with radiologic scores. Forty-three inpatients with active pulmonary tuberculosis and 19 healthy controls participated in the study. Patients were divided into four categories radiologically on chest X-ray (minimal, moderate-advanced, far-advanced and with miliary infiltration). Concentrations of TNF-α (20.9±10/15.4±8 pg/ml) and sIL-2R (2569±842/1444±514 pg/ml) were statistically different between patients and controls (p=0.02 and p=0.0001, respectively). Before chemotherapy there was a positive correlation between TNF-α and sIL-2R (r=0.34), but there was no correlation between IL-4 and TNF-α, and between IL-4 and sIL-2R (r=−0.23 and r=−0.22). The TNF-α level was not statistically different in four groups before and after chemotherapy. Results of this study provided some evidence confirming the previously reported role of TNF-α, IL-4 and sIL 2R in the control of tuberculosis, but these cytokines were not found related with disease severity. |
| format | Article |
| id | doaj-art-4feaa9993af546bcac5c8e7de27c2cf8 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2003-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-4feaa9993af546bcac5c8e7de27c2cf82025-02-03T00:59:10ZengWileyMediators of Inflammation0962-93511466-18612003-01-0112191410.1080/0962935031000096926Correlation of serum tumor necrosis factor-α, interleukin-4 and soluble interleukin-2 receptor levels with radiologic and clinical manifestations in active pulmonary tuberculosisLevent Kart0Hakan Buyukoglan1Ishak O. Tekin2Remzi Altin3Zuhal Senturk4Inci Gulmez5Ramazan Demir6Mustafa Ozesmi7Department of Pulmonary Medicine, Faculty of Medicine, Zonguldak Karaelmas University, Zonguldak 67600, TurkeyDepartment of Pulmonary Medicine, Faculty of Medicine, Erciyes University, TurkeyDepartment of Immunology, Faculty of Medicine, Zonguldak Karaelmas University, Zonguldak 67600, TurkeyDepartment of Pulmonary Medicine, Faculty of Medicine, Zonguldak Karaelmas University, Zonguldak 67600, TurkeyDepartment of Pulmonary Medicine, Faculty of Medicine, Erciyes University, TurkeyDepartment of Pulmonary Medicine, Faculty of Medicine, Erciyes University, TurkeyDepartment of Pulmonary Medicine, Faculty of Medicine, Erciyes University, TurkeyDepartment of Pulmonary Medicine, Faculty of Medicine, Erciyes University, TurkeyThe precise clinical manifestations of tuberculosis are likely to result from a complex interaction between the host and the pathogen. We took serum samples from a group of patients with a variety of clinical and radiological stages of pulmonary tuberculosis in order to characterize tumor necrosis factor-α (TNF-α), interleukin-4 (IL-4) and soluble interleukin-2 receptor (sIL-2R) response. We further evaluated whether the levels of TNF-α, IL-4 and soluble IL-2R are related with each other, and also evaluated the levels of TNF-α, IL-4 and sIL-2R after anti-tuberculosis therapy and relation with radiologic scores. Forty-three inpatients with active pulmonary tuberculosis and 19 healthy controls participated in the study. Patients were divided into four categories radiologically on chest X-ray (minimal, moderate-advanced, far-advanced and with miliary infiltration). Concentrations of TNF-α (20.9±10/15.4±8 pg/ml) and sIL-2R (2569±842/1444±514 pg/ml) were statistically different between patients and controls (p=0.02 and p=0.0001, respectively). Before chemotherapy there was a positive correlation between TNF-α and sIL-2R (r=0.34), but there was no correlation between IL-4 and TNF-α, and between IL-4 and sIL-2R (r=−0.23 and r=−0.22). The TNF-α level was not statistically different in four groups before and after chemotherapy. Results of this study provided some evidence confirming the previously reported role of TNF-α, IL-4 and sIL 2R in the control of tuberculosis, but these cytokines were not found related with disease severity.http://dx.doi.org/10.1080/0962935031000096926TuberculosisRadiologic manifestationCytokine. |
| spellingShingle | Levent Kart Hakan Buyukoglan Ishak O. Tekin Remzi Altin Zuhal Senturk Inci Gulmez Ramazan Demir Mustafa Ozesmi Correlation of serum tumor necrosis factor-α, interleukin-4 and soluble interleukin-2 receptor levels with radiologic and clinical manifestations in active pulmonary tuberculosis Mediators of Inflammation Tuberculosis Radiologic manifestation Cytokine. |
| title | Correlation of serum tumor necrosis factor-α, interleukin-4 and soluble interleukin-2 receptor levels with radiologic and clinical manifestations in active pulmonary tuberculosis |
| title_full | Correlation of serum tumor necrosis factor-α, interleukin-4 and soluble interleukin-2 receptor levels with radiologic and clinical manifestations in active pulmonary tuberculosis |
| title_fullStr | Correlation of serum tumor necrosis factor-α, interleukin-4 and soluble interleukin-2 receptor levels with radiologic and clinical manifestations in active pulmonary tuberculosis |
| title_full_unstemmed | Correlation of serum tumor necrosis factor-α, interleukin-4 and soluble interleukin-2 receptor levels with radiologic and clinical manifestations in active pulmonary tuberculosis |
| title_short | Correlation of serum tumor necrosis factor-α, interleukin-4 and soluble interleukin-2 receptor levels with radiologic and clinical manifestations in active pulmonary tuberculosis |
| title_sort | correlation of serum tumor necrosis factor α interleukin 4 and soluble interleukin 2 receptor levels with radiologic and clinical manifestations in active pulmonary tuberculosis |
| topic | Tuberculosis Radiologic manifestation Cytokine. |
| url | http://dx.doi.org/10.1080/0962935031000096926 |
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