Extracellular NM23 Protein as a Therapeutic Target for Hematologic Malignancies
An elevated serum level of NM23-H1 protein is a poor prognostic factor in patients with various hematologic malignancies. The extracellular NM23-H1 protein promotes the in vitro growth and survival of acute myelogenous leukemia (AML) cells and inversely inhibits the in vitro survival of normal perip...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2012/879368 |
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| _version_ | 1832568427236032512 |
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| author | Junko Okabe-Kado Takashi Kasukabe Yasuhiko Kaneko |
| author_facet | Junko Okabe-Kado Takashi Kasukabe Yasuhiko Kaneko |
| author_sort | Junko Okabe-Kado |
| collection | DOAJ |
| description | An elevated serum level of NM23-H1 protein is a poor prognostic factor in patients with various hematologic malignancies. The extracellular NM23-H1 protein promotes the in vitro growth and survival of acute myelogenous leukemia (AML) cells and inversely inhibits the in vitro survival of normal peripheral blood monocytes in primary culture at concentrations equivalent to the levels found in the serum of AML patients. The growth and survival promoting activity to AML cells is associated with cytokine production and activation of mitogen-activated protein kinases (MAPKs) and signal transducers and activators of transcription (STAT) signaling pathways. Inhibitors specific for MAPK signaling pathways inhibit the growth/survival-promoting activity of NM23-H1. These findings indicate a novel biological action of extracellular NM23-H1 and its association with poor prognosis. These results suggest an important role of extracellular NM23-H1 in the malignant progression of leukemia and a potential therapeutic target for these malignancies. |
| format | Article |
| id | doaj-art-4fe79bd736aa42239db6a0139655be4a |
| institution | Kabale University |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj-art-4fe79bd736aa42239db6a0139655be4a2025-02-03T00:58:59ZengWileyAdvances in Hematology1687-91041687-91122012-01-01201210.1155/2012/879368879368Extracellular NM23 Protein as a Therapeutic Target for Hematologic MalignanciesJunko Okabe-Kado0Takashi Kasukabe1Yasuhiko Kaneko2Research Institute for Clinical Oncology, Saitama Cancer Center, Komuro 818, Ina-machi, Saitama 362-0806, JapanResearch Institute for Clinical Oncology, Saitama Cancer Center, Komuro 818, Ina-machi, Saitama 362-0806, JapanResearch Institute for Clinical Oncology, Saitama Cancer Center, Komuro 818, Ina-machi, Saitama 362-0806, JapanAn elevated serum level of NM23-H1 protein is a poor prognostic factor in patients with various hematologic malignancies. The extracellular NM23-H1 protein promotes the in vitro growth and survival of acute myelogenous leukemia (AML) cells and inversely inhibits the in vitro survival of normal peripheral blood monocytes in primary culture at concentrations equivalent to the levels found in the serum of AML patients. The growth and survival promoting activity to AML cells is associated with cytokine production and activation of mitogen-activated protein kinases (MAPKs) and signal transducers and activators of transcription (STAT) signaling pathways. Inhibitors specific for MAPK signaling pathways inhibit the growth/survival-promoting activity of NM23-H1. These findings indicate a novel biological action of extracellular NM23-H1 and its association with poor prognosis. These results suggest an important role of extracellular NM23-H1 in the malignant progression of leukemia and a potential therapeutic target for these malignancies.http://dx.doi.org/10.1155/2012/879368 |
| spellingShingle | Junko Okabe-Kado Takashi Kasukabe Yasuhiko Kaneko Extracellular NM23 Protein as a Therapeutic Target for Hematologic Malignancies Advances in Hematology |
| title | Extracellular NM23 Protein as a Therapeutic Target for Hematologic Malignancies |
| title_full | Extracellular NM23 Protein as a Therapeutic Target for Hematologic Malignancies |
| title_fullStr | Extracellular NM23 Protein as a Therapeutic Target for Hematologic Malignancies |
| title_full_unstemmed | Extracellular NM23 Protein as a Therapeutic Target for Hematologic Malignancies |
| title_short | Extracellular NM23 Protein as a Therapeutic Target for Hematologic Malignancies |
| title_sort | extracellular nm23 protein as a therapeutic target for hematologic malignancies |
| url | http://dx.doi.org/10.1155/2012/879368 |
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