The Clinical and Prognostic Significance of Activated AKT-mTOR Pathway in Human Astrocytomas
Astrocytomas, the most common type of gliomas, and especially grade IV glioblastomas are “endowed” with strong proliferation and invasion potentials, high recurrence rate, and poor patients' prognosis. Aberrant signaling of AKT-mTOR (mammalian target of rapamycin) has been implicated in carcino...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Neurology Research International |
| Online Access: | http://dx.doi.org/10.1155/2012/454957 |
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| author | Elias A. El Habr Christos Adamopoulos Georgia Levidou Aggeliki A. Saetta Penelope Korkolopoulou Christina Piperi |
| author_facet | Elias A. El Habr Christos Adamopoulos Georgia Levidou Aggeliki A. Saetta Penelope Korkolopoulou Christina Piperi |
| author_sort | Elias A. El Habr |
| collection | DOAJ |
| description | Astrocytomas, the most common type of gliomas, and especially grade IV glioblastomas are “endowed” with strong proliferation and invasion potentials, high recurrence rate, and poor patients' prognosis. Aberrant signaling of AKT-mTOR (mammalian target of rapamycin) has been implicated in carcinogenesis. This paper is focused on the impact of deregulated AKT-mTOR signaling components in the clinical outcome and prognosis of human astrocytomas. Current therapeutic targeting of astrocytomas with AKT-mTOR inhibitors in preclinical and clinical stage is also discussed, including future perspectives regarding the management of these devastating tumors. |
| format | Article |
| id | doaj-art-4fe68ad024954d55b32bb182e9bd2212 |
| institution | Kabale University |
| issn | 2090-1852 2090-1860 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neurology Research International |
| spelling | doaj-art-4fe68ad024954d55b32bb182e9bd22122025-02-03T01:26:47ZengWileyNeurology Research International2090-18522090-18602012-01-01201210.1155/2012/454957454957The Clinical and Prognostic Significance of Activated AKT-mTOR Pathway in Human AstrocytomasElias A. El Habr0Christos Adamopoulos1Georgia Levidou2Aggeliki A. Saetta3Penelope Korkolopoulou4Christina Piperi5First Department of Pathology, Laiko Hospital, National and Kapodistrian University of Athens Medical School, 11527 Athens, GreeceDepartment of Biological Chemistry, National and Kapodistrian University of Athens Medical School, 11527 Athens, GreeceFirst Department of Pathology, Laiko Hospital, National and Kapodistrian University of Athens Medical School, 11527 Athens, GreeceFirst Department of Pathology, Laiko Hospital, National and Kapodistrian University of Athens Medical School, 11527 Athens, GreeceFirst Department of Pathology, Laiko Hospital, National and Kapodistrian University of Athens Medical School, 11527 Athens, GreeceDepartment of Biological Chemistry, National and Kapodistrian University of Athens Medical School, 11527 Athens, GreeceAstrocytomas, the most common type of gliomas, and especially grade IV glioblastomas are “endowed” with strong proliferation and invasion potentials, high recurrence rate, and poor patients' prognosis. Aberrant signaling of AKT-mTOR (mammalian target of rapamycin) has been implicated in carcinogenesis. This paper is focused on the impact of deregulated AKT-mTOR signaling components in the clinical outcome and prognosis of human astrocytomas. Current therapeutic targeting of astrocytomas with AKT-mTOR inhibitors in preclinical and clinical stage is also discussed, including future perspectives regarding the management of these devastating tumors.http://dx.doi.org/10.1155/2012/454957 |
| spellingShingle | Elias A. El Habr Christos Adamopoulos Georgia Levidou Aggeliki A. Saetta Penelope Korkolopoulou Christina Piperi The Clinical and Prognostic Significance of Activated AKT-mTOR Pathway in Human Astrocytomas Neurology Research International |
| title | The Clinical and Prognostic Significance of Activated AKT-mTOR Pathway in Human Astrocytomas |
| title_full | The Clinical and Prognostic Significance of Activated AKT-mTOR Pathway in Human Astrocytomas |
| title_fullStr | The Clinical and Prognostic Significance of Activated AKT-mTOR Pathway in Human Astrocytomas |
| title_full_unstemmed | The Clinical and Prognostic Significance of Activated AKT-mTOR Pathway in Human Astrocytomas |
| title_short | The Clinical and Prognostic Significance of Activated AKT-mTOR Pathway in Human Astrocytomas |
| title_sort | clinical and prognostic significance of activated akt mtor pathway in human astrocytomas |
| url | http://dx.doi.org/10.1155/2012/454957 |
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