Abnormal Circadian Modification of Aδ-Fiber Pathway Excitability in Idiopathic Restless Legs Syndrome
Restless legs syndrome (RLS) is characterized by unpleasant sensations generally localized to legs, associated with an urge to move. A likely pathogenetic mechanism is a central dopaminergic dysfunction. The exact role of pain system is unclear. The purpose of the study was to investigate the nocice...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Pain Research and Management |
| Online Access: | http://dx.doi.org/10.1155/2019/5408732 |
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| author | Catello Vollono Giacomo Della Marca Elisa Testani Anna Losurdo Daniela Virdis Diana Ferraro Valerio Brunetti Paolo M. Rossini Domenica Le Pera Salvatore Mazza Massimiliano Valeriani |
| author_facet | Catello Vollono Giacomo Della Marca Elisa Testani Anna Losurdo Daniela Virdis Diana Ferraro Valerio Brunetti Paolo M. Rossini Domenica Le Pera Salvatore Mazza Massimiliano Valeriani |
| author_sort | Catello Vollono |
| collection | DOAJ |
| description | Restless legs syndrome (RLS) is characterized by unpleasant sensations generally localized to legs, associated with an urge to move. A likely pathogenetic mechanism is a central dopaminergic dysfunction. The exact role of pain system is unclear. The purpose of the study was to investigate the nociceptive pathways in idiopathic RLS patients. We enrolled 11 patients (mean age 53.2 ± 19.7 years; 7 men) suffering from severe, primary RLS. We recorded scalp laser-evoked potentials (LEPs) to stimulation of different sites (hands and feet) and during two different time conditions (daytime and nighttime). Finally, we compared the results with a matched control group of healthy subjects. The Aδ responses obtained from patients did not differ from those recorded from control subjects. However, the N1 and the N2-P2 amplitudes’ night/day ratios after foot stimulation were increased in patients, as compared to controls (N1: patients: 133.91 ± 50.42%; controls: 83.74 ± 34.45%; p=0.016; Aδ-N2-P2: patients: 119.15 ± 15.56%; controls: 88.42 ± 23.41%; p=0.003). These results suggest that RLS patients present circadian modifications in the pain system, which are not present in healthy controls. Both sensory-discriminative and affective-emotional components of pain experience show parallel changes. This study confirms the structural integrity of Aδ nociceptive system in idiopathic RLS, but it also suggests that RLS patients present circadian modifications in the pain system. These findings could potentially help clinicians and contribute to identify new therapeutic approaches. |
| format | Article |
| id | doaj-art-4fde64c446ad44a4b487ae05465ae281 |
| institution | Kabale University |
| issn | 1203-6765 1918-1523 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pain Research and Management |
| spelling | doaj-art-4fde64c446ad44a4b487ae05465ae2812025-02-03T01:30:28ZengWileyPain Research and Management1203-67651918-15232019-01-01201910.1155/2019/54087325408732Abnormal Circadian Modification of Aδ-Fiber Pathway Excitability in Idiopathic Restless Legs SyndromeCatello Vollono0Giacomo Della Marca1Elisa Testani2Anna Losurdo3Daniela Virdis4Diana Ferraro5Valerio Brunetti6Paolo M. Rossini7Domenica Le Pera8Salvatore Mazza9Massimiliano Valeriani10Unit of Neurophysiopathology, Department of Geriatrics, Neurosciences and Orthopedics, Catholic University, Policlinico Universitario “A. Gemelli” IRCCS, Rome, ItalyUnit of Neurophysiopathology, Department of Geriatrics, Neurosciences and Orthopedics, Catholic University, Policlinico Universitario “A. Gemelli” IRCCS, Rome, ItalyUnit of Neurophysiopathology, Department of Geriatrics, Neurosciences and Orthopedics, Catholic University, Policlinico Universitario “A. Gemelli” IRCCS, Rome, ItalyUnit of Neurophysiopathology, Department of Geriatrics, Neurosciences and Orthopedics, Catholic University, Policlinico Universitario “A. Gemelli” IRCCS, Rome, ItalyUnit of Neurophysiopathology, Department of Geriatrics, Neurosciences and Orthopedics, Catholic University, Policlinico Universitario “A. Gemelli” IRCCS, Rome, ItalyNeurology Unit, Department of Neurosciences, University of Modena and Reggio Emilia, Modena, ItalyUnit of Neurophysiopathology, Department of Geriatrics, Neurosciences and Orthopedics, Catholic University, Policlinico Universitario “A. Gemelli” IRCCS, Rome, ItalyUnit of Neurophysiopathology, Department of Geriatrics, Neurosciences and Orthopedics, Catholic University, Policlinico Universitario “A. Gemelli” IRCCS, Rome, ItalyArea Neuroscienze, San Raffaele Pisana IRCCS, Rome, ItalyUnit of Neurophysiopathology, Department of Geriatrics, Neurosciences and Orthopedics, Catholic University, Policlinico Universitario “A. Gemelli” IRCCS, Rome, ItalyNeurology Division, Pediatric Hospital “Bambino Gesù” IRCCS, Rome, ItalyRestless legs syndrome (RLS) is characterized by unpleasant sensations generally localized to legs, associated with an urge to move. A likely pathogenetic mechanism is a central dopaminergic dysfunction. The exact role of pain system is unclear. The purpose of the study was to investigate the nociceptive pathways in idiopathic RLS patients. We enrolled 11 patients (mean age 53.2 ± 19.7 years; 7 men) suffering from severe, primary RLS. We recorded scalp laser-evoked potentials (LEPs) to stimulation of different sites (hands and feet) and during two different time conditions (daytime and nighttime). Finally, we compared the results with a matched control group of healthy subjects. The Aδ responses obtained from patients did not differ from those recorded from control subjects. However, the N1 and the N2-P2 amplitudes’ night/day ratios after foot stimulation were increased in patients, as compared to controls (N1: patients: 133.91 ± 50.42%; controls: 83.74 ± 34.45%; p=0.016; Aδ-N2-P2: patients: 119.15 ± 15.56%; controls: 88.42 ± 23.41%; p=0.003). These results suggest that RLS patients present circadian modifications in the pain system, which are not present in healthy controls. Both sensory-discriminative and affective-emotional components of pain experience show parallel changes. This study confirms the structural integrity of Aδ nociceptive system in idiopathic RLS, but it also suggests that RLS patients present circadian modifications in the pain system. These findings could potentially help clinicians and contribute to identify new therapeutic approaches.http://dx.doi.org/10.1155/2019/5408732 |
| spellingShingle | Catello Vollono Giacomo Della Marca Elisa Testani Anna Losurdo Daniela Virdis Diana Ferraro Valerio Brunetti Paolo M. Rossini Domenica Le Pera Salvatore Mazza Massimiliano Valeriani Abnormal Circadian Modification of Aδ-Fiber Pathway Excitability in Idiopathic Restless Legs Syndrome Pain Research and Management |
| title | Abnormal Circadian Modification of Aδ-Fiber Pathway Excitability in Idiopathic Restless Legs Syndrome |
| title_full | Abnormal Circadian Modification of Aδ-Fiber Pathway Excitability in Idiopathic Restless Legs Syndrome |
| title_fullStr | Abnormal Circadian Modification of Aδ-Fiber Pathway Excitability in Idiopathic Restless Legs Syndrome |
| title_full_unstemmed | Abnormal Circadian Modification of Aδ-Fiber Pathway Excitability in Idiopathic Restless Legs Syndrome |
| title_short | Abnormal Circadian Modification of Aδ-Fiber Pathway Excitability in Idiopathic Restless Legs Syndrome |
| title_sort | abnormal circadian modification of aδ fiber pathway excitability in idiopathic restless legs syndrome |
| url | http://dx.doi.org/10.1155/2019/5408732 |
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