PAF and Haematopoiesis. I. 5-Fluoro-Uracil Induces PAF Production in Haematopoietic Organs of Rats
Haematopoietic organs of rats were examined for the presence of platelet-activating factor (PAF) and acetylhydrolase before and after treatment with 5-fluoro-uracil (5-FU) (200 mg/kg) a chemotherapeutic compound with apoptotic effects. PAF was reported in thymus, spleen and femoral bone marrow of ra...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1994-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935194000049 |
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| Summary: | Haematopoietic organs of rats were examined for the presence of
platelet-activating factor (PAF) and acetylhydrolase before and
after treatment with 5-fluoro-uracil (5-FU) (200 mg/kg) a
chemotherapeutic compound with apoptotic effects. PAF was reported
in thymus, spleen and femoral bone marrow of rats with or without
5-FU. Although acetylhydrolase activity in organs was not affected
by 5-FU treatment, elevated levels of PAF were observed in thymus
and spleen. For the first time PAF is reported in haematopoietic
organs of rats, strengthening in vitro data suggesting its role in
the apoptotic processes in thymus, in the modulation of the immune
response, and in the regulation of haematopoiesis. |
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| ISSN: | 0962-9351 1466-1861 |