Design and Performance Analysis of ISFET Using Various Oxide Materials for Biosensing Applications
The healthcare industry is constantly changing because of technological breakthroughs that spur new methods of diagnosing and treating illnesses. This study investigates the development of Ion Sensitive Field Effect Transistor (ISFET) sensors for DNA-based blood cancer diagnosis. This work presents...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
IEEE
2024-01-01
|
| Series: | IEEE Open Journal of Nanotechnology |
| Subjects: | |
| Online Access: | https://ieeexplore.ieee.org/document/10547399/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832590325067022336 |
|---|---|
| author | Sankararao Majji Asisa Kumar Panigrahy Depuru Shobha Rani Muralidhar Nayak Bhukya Chandra Sekhar Dash |
| author_facet | Sankararao Majji Asisa Kumar Panigrahy Depuru Shobha Rani Muralidhar Nayak Bhukya Chandra Sekhar Dash |
| author_sort | Sankararao Majji |
| collection | DOAJ |
| description | The healthcare industry is constantly changing because of technological breakthroughs that spur new methods of diagnosing and treating illnesses. This study investigates the development of Ion Sensitive Field Effect Transistor (ISFET) sensors for DNA-based blood cancer diagnosis. This work presents the design of a two-dimensional ion-sensitive field-effect transistor. Concentration fluctuations and transfer characteristics with different oxides are studied using blood from two electrolyte solutions. It is possible to evaluate how the modeled device can be utilized as a pH sensor or a biosensor in healthcare applications by looking at how the pH changes for different oxides. Additionally, several oxides were examined in the simulated ISFET devices' output characteristics. Blood is the electrolyte to study the device's sensitivity for different oxides. When pH 7.4 is considered, SiO<sub>2</sub> oxide is significantly more sensitive than other oxides. The resulting 2D-ISFET exhibits remarkable blood electrolyte sensitivity and holds potential as a quick detection tool for blood cancer. The results show that the ISFET possesses drain-induced barrier lowering (DIBL), greater ON-current <italic>(I<sub>ON</sub></italic>) and switching ratio (<italic>I<sub>ON</sub>/I<sub>OFF</sub></italic>), and decreased subthreshold swing (SS). The pH sensor's sensitivity and the suggested equipment can detect up to 30 fg/mL of blood cancer biomarkers. An important development in technology-driven healthcare is the emergence of DNA-based blood cancer detection utilizing ISFET sensors. This opens up new avenues for improving cancer diagnosis and patient outcomes. |
| format | Article |
| id | doaj-art-4fc629b1967c41c4b8df75d59a993791 |
| institution | Kabale University |
| issn | 2644-1292 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | IEEE |
| record_format | Article |
| series | IEEE Open Journal of Nanotechnology |
| spelling | doaj-art-4fc629b1967c41c4b8df75d59a9937912025-01-24T00:02:28ZengIEEEIEEE Open Journal of Nanotechnology2644-12922024-01-015232910.1109/OJNANO.2024.340884510547399Design and Performance Analysis of ISFET Using Various Oxide Materials for Biosensing ApplicationsSankararao Majji0https://orcid.org/0000-0003-0982-3401Asisa Kumar Panigrahy1https://orcid.org/0000-0002-9491-5310Depuru Shobha Rani2https://orcid.org/0000-0001-8235-9671Muralidhar Nayak Bhukya3https://orcid.org/0000-0002-6782-0738Chandra Sekhar Dash4https://orcid.org/0000-0002-1379-0342Department of ECE, Centurion University of Technology and Management, Odisha, Bhubaneswar, IndiaDepartment of ECE, Faculty of Science and Technology (IcfaiTech), ICFAI foundation for Higher Education, Hyderabad, IndiaDepartment of Electrical and Electronics Engineering, Institute of Aeronautical Engineering, Hyderabad, IndiaDepartment of Electrical Engineering, School of Engineering and Technology, Central University of Haryana, Mahendragarh, IndiaDepartment of ECE, Centurion University of Technology and Management, Odisha, Bhubaneswar, IndiaThe healthcare industry is constantly changing because of technological breakthroughs that spur new methods of diagnosing and treating illnesses. This study investigates the development of Ion Sensitive Field Effect Transistor (ISFET) sensors for DNA-based blood cancer diagnosis. This work presents the design of a two-dimensional ion-sensitive field-effect transistor. Concentration fluctuations and transfer characteristics with different oxides are studied using blood from two electrolyte solutions. It is possible to evaluate how the modeled device can be utilized as a pH sensor or a biosensor in healthcare applications by looking at how the pH changes for different oxides. Additionally, several oxides were examined in the simulated ISFET devices' output characteristics. Blood is the electrolyte to study the device's sensitivity for different oxides. When pH 7.4 is considered, SiO<sub>2</sub> oxide is significantly more sensitive than other oxides. The resulting 2D-ISFET exhibits remarkable blood electrolyte sensitivity and holds potential as a quick detection tool for blood cancer. The results show that the ISFET possesses drain-induced barrier lowering (DIBL), greater ON-current <italic>(I<sub>ON</sub></italic>) and switching ratio (<italic>I<sub>ON</sub>/I<sub>OFF</sub></italic>), and decreased subthreshold swing (SS). The pH sensor's sensitivity and the suggested equipment can detect up to 30 fg/mL of blood cancer biomarkers. An important development in technology-driven healthcare is the emergence of DNA-based blood cancer detection utilizing ISFET sensors. This opens up new avenues for improving cancer diagnosis and patient outcomes.https://ieeexplore.ieee.org/document/10547399/Blood cancercancer diagnostics2D-ISFETIon Sensitive Field Effect Transistor (ISFET)ISFET sensorsLOD |
| spellingShingle | Sankararao Majji Asisa Kumar Panigrahy Depuru Shobha Rani Muralidhar Nayak Bhukya Chandra Sekhar Dash Design and Performance Analysis of ISFET Using Various Oxide Materials for Biosensing Applications IEEE Open Journal of Nanotechnology Blood cancer cancer diagnostics 2D-ISFET Ion Sensitive Field Effect Transistor (ISFET) ISFET sensors LOD |
| title | Design and Performance Analysis of ISFET Using Various Oxide Materials for Biosensing Applications |
| title_full | Design and Performance Analysis of ISFET Using Various Oxide Materials for Biosensing Applications |
| title_fullStr | Design and Performance Analysis of ISFET Using Various Oxide Materials for Biosensing Applications |
| title_full_unstemmed | Design and Performance Analysis of ISFET Using Various Oxide Materials for Biosensing Applications |
| title_short | Design and Performance Analysis of ISFET Using Various Oxide Materials for Biosensing Applications |
| title_sort | design and performance analysis of isfet using various oxide materials for biosensing applications |
| topic | Blood cancer cancer diagnostics 2D-ISFET Ion Sensitive Field Effect Transistor (ISFET) ISFET sensors LOD |
| url | https://ieeexplore.ieee.org/document/10547399/ |
| work_keys_str_mv | AT sankararaomajji designandperformanceanalysisofisfetusingvariousoxidematerialsforbiosensingapplications AT asisakumarpanigrahy designandperformanceanalysisofisfetusingvariousoxidematerialsforbiosensingapplications AT depurushobharani designandperformanceanalysisofisfetusingvariousoxidematerialsforbiosensingapplications AT muralidharnayakbhukya designandperformanceanalysisofisfetusingvariousoxidematerialsforbiosensingapplications AT chandrasekhardash designandperformanceanalysisofisfetusingvariousoxidematerialsforbiosensingapplications |