Long Course Hyperbaric Oxygen Stimulates Neurogenesis and Attenuates Inflammation after Ischemic Stroke
Several studies have provided evidence with regard to the neuroprotection benefits of hyperbaric oxygen (HBO) therapy in cases of stroke, and HBO also promotes bone marrow stem cells (BMSCs) proliferation and mobilization. This study investigates the influence of HBO therapy on the migration of BMSC...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/512978 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832549509922553856 |
|---|---|
| author | Ying-Sheng Lee Chung-Ching Chio Ching-Ping Chang Liang-Chao Wang Po-Min Chiang Kuo-Chi Niu Kuen-Jer Tsai |
| author_facet | Ying-Sheng Lee Chung-Ching Chio Ching-Ping Chang Liang-Chao Wang Po-Min Chiang Kuo-Chi Niu Kuen-Jer Tsai |
| author_sort | Ying-Sheng Lee |
| collection | DOAJ |
| description | Several studies have provided evidence with regard to the neuroprotection benefits of hyperbaric oxygen (HBO) therapy in cases of stroke, and HBO also promotes bone marrow stem cells (BMSCs) proliferation and mobilization. This study investigates the influence of HBO therapy on the migration of BMSCs, neurogenesis, gliosis, and inflammation after stroke. Rats that sustained transient middle cerebral artery occlusion (MCAO) were treated with HBO three weeks or two days. The results were examined using a behavior test (modified neurological severity score, mNSS) and immunostaining to evaluate the effects of HBO therapy on migration of BMSCs, neurogenesis, and gliosis, and expression of neurotrophic factors was also evaluated. There was a lower mNSS score in the three-week HBO group when compared with the two-day HBO group. Mobilization of BMSCs to an ischemic area was more improved in long course HBO treatments, suggesting the duration of therapy is crucial for promoting the homing of BMSCs to ischemic brain by HBO therapies. HBO also can stimulate expression of trophic factors and improve neurogenesis and gliosis. These effects may help in neuronal repair after ischemic stroke, and increasing the course of HBO therapy might enhance therapeutic effects on ischemic stroke. |
| format | Article |
| id | doaj-art-4fb4c717ad7e4e4b9e2211a1a6f43972 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-4fb4c717ad7e4e4b9e2211a1a6f439722025-02-03T06:11:05ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/512978512978Long Course Hyperbaric Oxygen Stimulates Neurogenesis and Attenuates Inflammation after Ischemic StrokeYing-Sheng Lee0Chung-Ching Chio1Ching-Ping Chang2Liang-Chao Wang3Po-Min Chiang4Kuo-Chi Niu5Kuen-Jer Tsai6Institute of Clinical Medicine, National Cheng Kung University, Tainan 704, TaiwanDepartment of Surgery, Chi Mei Medical Center, Tainan 710, TaiwanDepartment of Biotechnology, Southern Taiwan University, Tainan 710, TaiwanInstitute of Clinical Medicine, National Cheng Kung University, Tainan 704, TaiwanInstitute of Clinical Medicine, National Cheng Kung University, Tainan 704, TaiwanDepartment of Surgery, Chi Mei Medical Center, Tainan 710, TaiwanInstitute of Clinical Medicine, National Cheng Kung University, Tainan 704, TaiwanSeveral studies have provided evidence with regard to the neuroprotection benefits of hyperbaric oxygen (HBO) therapy in cases of stroke, and HBO also promotes bone marrow stem cells (BMSCs) proliferation and mobilization. This study investigates the influence of HBO therapy on the migration of BMSCs, neurogenesis, gliosis, and inflammation after stroke. Rats that sustained transient middle cerebral artery occlusion (MCAO) were treated with HBO three weeks or two days. The results were examined using a behavior test (modified neurological severity score, mNSS) and immunostaining to evaluate the effects of HBO therapy on migration of BMSCs, neurogenesis, and gliosis, and expression of neurotrophic factors was also evaluated. There was a lower mNSS score in the three-week HBO group when compared with the two-day HBO group. Mobilization of BMSCs to an ischemic area was more improved in long course HBO treatments, suggesting the duration of therapy is crucial for promoting the homing of BMSCs to ischemic brain by HBO therapies. HBO also can stimulate expression of trophic factors and improve neurogenesis and gliosis. These effects may help in neuronal repair after ischemic stroke, and increasing the course of HBO therapy might enhance therapeutic effects on ischemic stroke.http://dx.doi.org/10.1155/2013/512978 |
| spellingShingle | Ying-Sheng Lee Chung-Ching Chio Ching-Ping Chang Liang-Chao Wang Po-Min Chiang Kuo-Chi Niu Kuen-Jer Tsai Long Course Hyperbaric Oxygen Stimulates Neurogenesis and Attenuates Inflammation after Ischemic Stroke Mediators of Inflammation |
| title | Long Course Hyperbaric Oxygen Stimulates Neurogenesis and Attenuates Inflammation after Ischemic Stroke |
| title_full | Long Course Hyperbaric Oxygen Stimulates Neurogenesis and Attenuates Inflammation after Ischemic Stroke |
| title_fullStr | Long Course Hyperbaric Oxygen Stimulates Neurogenesis and Attenuates Inflammation after Ischemic Stroke |
| title_full_unstemmed | Long Course Hyperbaric Oxygen Stimulates Neurogenesis and Attenuates Inflammation after Ischemic Stroke |
| title_short | Long Course Hyperbaric Oxygen Stimulates Neurogenesis and Attenuates Inflammation after Ischemic Stroke |
| title_sort | long course hyperbaric oxygen stimulates neurogenesis and attenuates inflammation after ischemic stroke |
| url | http://dx.doi.org/10.1155/2013/512978 |
| work_keys_str_mv | AT yingshenglee longcoursehyperbaricoxygenstimulatesneurogenesisandattenuatesinflammationafterischemicstroke AT chungchingchio longcoursehyperbaricoxygenstimulatesneurogenesisandattenuatesinflammationafterischemicstroke AT chingpingchang longcoursehyperbaricoxygenstimulatesneurogenesisandattenuatesinflammationafterischemicstroke AT liangchaowang longcoursehyperbaricoxygenstimulatesneurogenesisandattenuatesinflammationafterischemicstroke AT pominchiang longcoursehyperbaricoxygenstimulatesneurogenesisandattenuatesinflammationafterischemicstroke AT kuochiniu longcoursehyperbaricoxygenstimulatesneurogenesisandattenuatesinflammationafterischemicstroke AT kuenjertsai longcoursehyperbaricoxygenstimulatesneurogenesisandattenuatesinflammationafterischemicstroke |