Molecular Imaging Probes for Diagnosis and Therapy Evaluation of Breast Cancer
Breast cancer is a major cause of cancer death in women where early detection and accurate assessment of therapy response can improve clinical outcomes. Molecular imaging, which includes PET, SPECT, MRI, and optical modalities, provides noninvasive means of detecting biological processes and molecul...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | International Journal of Biomedical Imaging |
| Online Access: | http://dx.doi.org/10.1155/2013/230487 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832564122257981440 |
|---|---|
| author | Qingqing Meng Zheng Li |
| author_facet | Qingqing Meng Zheng Li |
| author_sort | Qingqing Meng |
| collection | DOAJ |
| description | Breast cancer is a major cause of cancer death in women where early detection and accurate assessment of therapy response can improve clinical outcomes. Molecular imaging, which includes PET, SPECT, MRI, and optical modalities, provides noninvasive means of detecting biological processes and molecular events in vivo. Molecular imaging has the potential to enhance our understanding of breast cancer biology and effects of drug action during both preclinical and clinical phases of drug development. This has led to the identification of many molecular imaging probes for key processes in breast cancer. Hormone receptors, growth factor receptor, and angiogenic factors, such as ER, PR, HER2, and VEGFR, have been adopted as imaging targets to detect and stage the breast cancer and to monitor the treatment efficacy. Receptor imaging probes are usually composed of targeting moiety attached to a signaling component such as a radionuclide that can be detected using dedicated instruments. Current molecular imaging probes involved in breast cancer diagnosis and therapy evaluation are reviewed, and future of molecular imaging for the preclinical and clinical is explained. |
| format | Article |
| id | doaj-art-4f991b8d62984c40b962933058c075e2 |
| institution | Kabale University |
| issn | 1687-4188 1687-4196 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomedical Imaging |
| spelling | doaj-art-4f991b8d62984c40b962933058c075e22025-02-03T01:11:47ZengWileyInternational Journal of Biomedical Imaging1687-41881687-41962013-01-01201310.1155/2013/230487230487Molecular Imaging Probes for Diagnosis and Therapy Evaluation of Breast CancerQingqing Meng0Zheng Li1Department of Translational Imaging, The Methodist Hospital Research Institute, Weill Cornell Medical College, 6670 Bertner Avenue, Houston, TX 77030, USADepartment of Translational Imaging, The Methodist Hospital Research Institute, Weill Cornell Medical College, 6670 Bertner Avenue, Houston, TX 77030, USABreast cancer is a major cause of cancer death in women where early detection and accurate assessment of therapy response can improve clinical outcomes. Molecular imaging, which includes PET, SPECT, MRI, and optical modalities, provides noninvasive means of detecting biological processes and molecular events in vivo. Molecular imaging has the potential to enhance our understanding of breast cancer biology and effects of drug action during both preclinical and clinical phases of drug development. This has led to the identification of many molecular imaging probes for key processes in breast cancer. Hormone receptors, growth factor receptor, and angiogenic factors, such as ER, PR, HER2, and VEGFR, have been adopted as imaging targets to detect and stage the breast cancer and to monitor the treatment efficacy. Receptor imaging probes are usually composed of targeting moiety attached to a signaling component such as a radionuclide that can be detected using dedicated instruments. Current molecular imaging probes involved in breast cancer diagnosis and therapy evaluation are reviewed, and future of molecular imaging for the preclinical and clinical is explained.http://dx.doi.org/10.1155/2013/230487 |
| spellingShingle | Qingqing Meng Zheng Li Molecular Imaging Probes for Diagnosis and Therapy Evaluation of Breast Cancer International Journal of Biomedical Imaging |
| title | Molecular Imaging Probes for Diagnosis and Therapy Evaluation of Breast Cancer |
| title_full | Molecular Imaging Probes for Diagnosis and Therapy Evaluation of Breast Cancer |
| title_fullStr | Molecular Imaging Probes for Diagnosis and Therapy Evaluation of Breast Cancer |
| title_full_unstemmed | Molecular Imaging Probes for Diagnosis and Therapy Evaluation of Breast Cancer |
| title_short | Molecular Imaging Probes for Diagnosis and Therapy Evaluation of Breast Cancer |
| title_sort | molecular imaging probes for diagnosis and therapy evaluation of breast cancer |
| url | http://dx.doi.org/10.1155/2013/230487 |
| work_keys_str_mv | AT qingqingmeng molecularimagingprobesfordiagnosisandtherapyevaluationofbreastcancer AT zhengli molecularimagingprobesfordiagnosisandtherapyevaluationofbreastcancer |