CPT1A mediated preservation of mitochondrial inhibits pyroptosis in pancreatic acinar cells

CPT1A mediated preservation of mitochondrial inhibits pyroptosis in pancreatic acinar cells

IntroductionCarnitine palmitoyltransferase 1A (CPT1A) is crucial for mitochondrial function, and its dysfunction has been linked to the development of several diseases. However, the role of CPT1A in severe acute pancreatitis (SAP) and its underlying mechanisms remain unclear. Mitochondrial damage-me...

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Bibliographic Details
Main Authors: Yijiang Liu, Yangbo Liu, Xiuxian Yu, Simin Tian, Xiaojuan Li, Yu Gao, Xin Bao, Xiaoyi Wu, Boli Zhang, Wen Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
acute pancreatitis
CPT1A
mitochondrial dysfunction
pyroptosis
L-carnitine
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1577669/full
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