WHO-Point prevalence survey of antibiotic use in a Senegalese tertiary care hospital.
The inappropriate use of antibiotics in human medicine is one of the primary causes of antimicrobial resistance. The objective of this study was to estimate the prevalence of antibiotic use at Dakar Principal Hospital and to identify factors associated with the prescription of broad-spectrum antibio...
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLOS Global Public Health |
| Online Access: | https://doi.org/10.1371/journal.pgph.0004887 |
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| author | Moustapha Diop Fatimata Wone Oumar Bassoum Mariéme Ndiaye Adji Marème Diagne Tracie Youbong Sokhna Moumi Mbacké Daffé Maguette Ndoye Ajuamendem Ghogomu Tamouh Mamadou Wagué Gueye Mor Ngom Bécaye Fall Papa Samba Ba Adama Faye |
| author_facet | Moustapha Diop Fatimata Wone Oumar Bassoum Mariéme Ndiaye Adji Marème Diagne Tracie Youbong Sokhna Moumi Mbacké Daffé Maguette Ndoye Ajuamendem Ghogomu Tamouh Mamadou Wagué Gueye Mor Ngom Bécaye Fall Papa Samba Ba Adama Faye |
| author_sort | Moustapha Diop |
| collection | DOAJ |
| description | The inappropriate use of antibiotics in human medicine is one of the primary causes of antimicrobial resistance. The objective of this study was to estimate the prevalence of antibiotic use at Dakar Principal Hospital and to identify factors associated with the prescription of broad-spectrum antibiotics. This cross-sectional study, conducted according to the WHO-point prevalence survey method, included all patients hospitalized in acute care wards who presented at 8:00 AM on the day of the survey. Data were collected from 9 to 29 December 2024 on working days. Multivariate logistic regression was performed to identify factors associated with the prescription of broad-spectrum antibiotics. A total of 222 patients, predominantly male (sex ratio = 1.26), were included. The median age of patients over 2 years was 45 years (interquartile range: 29-64 years). In total, 158 antibiotic prescriptions were reported for 101 included patients, resulting in a prevalence of 45.5% (101/222) and a prescription ratio of 1.56 antibiotics per patient. The most commonly prescribed antibiotics were amoxicillin-clavulanic acid (n = 36; 16.2%), followed by ceftriaxone (n = 21; 9.5%). Community acquired infection was the most common reason for prescription (n = 86; 54.4%), and 98 prescriptions (62%) were in compliance with the local guidelines. Antibiotics from the watch group of the AWaRe classification were used in 55 patients (54.4%). According to the multivariate analysis, the presence of a healthcare-associated infection was associated with this use (OR = 12.1; 95% CI [2.62-93.7]). These antibiotics from the watch group were significantly less commonly prescribed for surgical prophylaxis (OR = 0.13; 95% CI [0.02 - 0.63]). The prevalence of antibiotic use was high in the studied facility, with more prescriptions belonging to the watch group. These results underscore the need to strengthen antimicrobial stewardship policies. |
| format | Article |
| id | doaj-art-4f8c9e10f8354e78b17c0ada8b9524c3 |
| institution | Kabale University |
| issn | 2767-3375 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLOS Global Public Health |
| spelling | doaj-art-4f8c9e10f8354e78b17c0ada8b9524c32025-08-20T03:36:10ZengPublic Library of Science (PLoS)PLOS Global Public Health2767-33752025-01-0157e000488710.1371/journal.pgph.0004887WHO-Point prevalence survey of antibiotic use in a Senegalese tertiary care hospital.Moustapha DiopFatimata WoneOumar BassoumMariéme NdiayeAdji Marème DiagneTracie YoubongSokhna Moumi Mbacké DafféMaguette NdoyeAjuamendem Ghogomu TamouhMamadou Wagué GueyeMor NgomBécaye FallPapa Samba BaAdama FayeThe inappropriate use of antibiotics in human medicine is one of the primary causes of antimicrobial resistance. The objective of this study was to estimate the prevalence of antibiotic use at Dakar Principal Hospital and to identify factors associated with the prescription of broad-spectrum antibiotics. This cross-sectional study, conducted according to the WHO-point prevalence survey method, included all patients hospitalized in acute care wards who presented at 8:00 AM on the day of the survey. Data were collected from 9 to 29 December 2024 on working days. Multivariate logistic regression was performed to identify factors associated with the prescription of broad-spectrum antibiotics. A total of 222 patients, predominantly male (sex ratio = 1.26), were included. The median age of patients over 2 years was 45 years (interquartile range: 29-64 years). In total, 158 antibiotic prescriptions were reported for 101 included patients, resulting in a prevalence of 45.5% (101/222) and a prescription ratio of 1.56 antibiotics per patient. The most commonly prescribed antibiotics were amoxicillin-clavulanic acid (n = 36; 16.2%), followed by ceftriaxone (n = 21; 9.5%). Community acquired infection was the most common reason for prescription (n = 86; 54.4%), and 98 prescriptions (62%) were in compliance with the local guidelines. Antibiotics from the watch group of the AWaRe classification were used in 55 patients (54.4%). According to the multivariate analysis, the presence of a healthcare-associated infection was associated with this use (OR = 12.1; 95% CI [2.62-93.7]). These antibiotics from the watch group were significantly less commonly prescribed for surgical prophylaxis (OR = 0.13; 95% CI [0.02 - 0.63]). The prevalence of antibiotic use was high in the studied facility, with more prescriptions belonging to the watch group. These results underscore the need to strengthen antimicrobial stewardship policies.https://doi.org/10.1371/journal.pgph.0004887 |
| spellingShingle | Moustapha Diop Fatimata Wone Oumar Bassoum Mariéme Ndiaye Adji Marème Diagne Tracie Youbong Sokhna Moumi Mbacké Daffé Maguette Ndoye Ajuamendem Ghogomu Tamouh Mamadou Wagué Gueye Mor Ngom Bécaye Fall Papa Samba Ba Adama Faye WHO-Point prevalence survey of antibiotic use in a Senegalese tertiary care hospital. PLOS Global Public Health |
| title | WHO-Point prevalence survey of antibiotic use in a Senegalese tertiary care hospital. |
| title_full | WHO-Point prevalence survey of antibiotic use in a Senegalese tertiary care hospital. |
| title_fullStr | WHO-Point prevalence survey of antibiotic use in a Senegalese tertiary care hospital. |
| title_full_unstemmed | WHO-Point prevalence survey of antibiotic use in a Senegalese tertiary care hospital. |
| title_short | WHO-Point prevalence survey of antibiotic use in a Senegalese tertiary care hospital. |
| title_sort | who point prevalence survey of antibiotic use in a senegalese tertiary care hospital |
| url | https://doi.org/10.1371/journal.pgph.0004887 |
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