Looking beyond silybin: the importance of other silymarin flavonolignans
Silymarin, an extract from the seeds of milk thistle (Silybum marianum), has been widely studied and used for its hepatoprotective and pharmacological properties. For decades, both experimental and clinical research has been predominantly focused on a single component, silybin, while other related f...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1637393/full |
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| author | Michal Selc Michal Selc Andrea Babelova Andrea Babelova |
| author_facet | Michal Selc Michal Selc Andrea Babelova Andrea Babelova |
| author_sort | Michal Selc |
| collection | DOAJ |
| description | Silymarin, an extract from the seeds of milk thistle (Silybum marianum), has been widely studied and used for its hepatoprotective and pharmacological properties. For decades, both experimental and clinical research has been predominantly focused on a single component, silybin, while other related flavonolignans, such as silychristin, isosilybins, silydianin, dehydrosilybin, and the flavonoid taxifolin, have been understudied. However, these less known components may possess unique or even superior pharmacological activities compared to silybin, including strong antioxidant, anti-inflammatory, antiviral, and selective anticancer effects. Exploring these other constituents beyond silybin may unlock new opportunities for drug discovery and personalized phytotherapy, ultimately advancing the development of next-generation flavonolignan-based therapeutics. |
| format | Article |
| id | doaj-art-4f8a2a92797f4e44b54c860a227b4e9a |
| institution | DOAJ |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-4f8a2a92797f4e44b54c860a227b4e9a2025-08-20T03:13:22ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-07-011610.3389/fphar.2025.16373931637393Looking beyond silybin: the importance of other silymarin flavonolignansMichal Selc0Michal Selc1Andrea Babelova2Andrea Babelova3Centre for Advanced Material Application, Slovak Academy of Sciences, Bratislava, SlovakiaDepartment of Nanobiology, Cancer Research Institute, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, SlovakiaCentre for Advanced Material Application, Slovak Academy of Sciences, Bratislava, SlovakiaDepartment of Nanobiology, Cancer Research Institute, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, SlovakiaSilymarin, an extract from the seeds of milk thistle (Silybum marianum), has been widely studied and used for its hepatoprotective and pharmacological properties. For decades, both experimental and clinical research has been predominantly focused on a single component, silybin, while other related flavonolignans, such as silychristin, isosilybins, silydianin, dehydrosilybin, and the flavonoid taxifolin, have been understudied. However, these less known components may possess unique or even superior pharmacological activities compared to silybin, including strong antioxidant, anti-inflammatory, antiviral, and selective anticancer effects. Exploring these other constituents beyond silybin may unlock new opportunities for drug discovery and personalized phytotherapy, ultimately advancing the development of next-generation flavonolignan-based therapeutics.https://www.frontiersin.org/articles/10.3389/fphar.2025.1637393/fullsilymarinsilybinflavonolignansnatural productsresearch bias |
| spellingShingle | Michal Selc Michal Selc Andrea Babelova Andrea Babelova Looking beyond silybin: the importance of other silymarin flavonolignans Frontiers in Pharmacology silymarin silybin flavonolignans natural products research bias |
| title | Looking beyond silybin: the importance of other silymarin flavonolignans |
| title_full | Looking beyond silybin: the importance of other silymarin flavonolignans |
| title_fullStr | Looking beyond silybin: the importance of other silymarin flavonolignans |
| title_full_unstemmed | Looking beyond silybin: the importance of other silymarin flavonolignans |
| title_short | Looking beyond silybin: the importance of other silymarin flavonolignans |
| title_sort | looking beyond silybin the importance of other silymarin flavonolignans |
| topic | silymarin silybin flavonolignans natural products research bias |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1637393/full |
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