Immunopathology of Postprimary Tuberculosis: Increased T-Regulatory Cells and DEC-205-Positive Foamy Macrophages in Cavitary Lesions
Postprimary tuberculosis occurs in immunocompetent people infected with Mycobacterium tuberculosis. It is restricted to the lung and accounts for 80% of cases and nearly 100% of transmission. Little is known about the immunopathology of postprimary tuberculosis due to limited availability of specime...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2011/307631 |
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| author | Kerry J. Welsh Semyon A. Risin Jeffrey K. Actor Robert L. Hunter |
| author_facet | Kerry J. Welsh Semyon A. Risin Jeffrey K. Actor Robert L. Hunter |
| author_sort | Kerry J. Welsh |
| collection | DOAJ |
| description | Postprimary tuberculosis occurs in immunocompetent people infected with Mycobacterium tuberculosis. It is restricted to the lung and accounts for 80% of cases and nearly 100% of transmission. Little is known about the immunopathology of postprimary tuberculosis due to limited availability of specimens. Tissues from 30 autopsy cases of pulmonary tuberculosis were located. Sections of characteristic lesions of caseating granulomas, lipid pneumonia, and cavitary stages of postprimary disease were selected for immunohistochemical studies of macrophages, lymphocytes, endothelial cells, and mycobacterial antigens. A higher percentage of cells in lipid pneumonia (36.1%) and cavitary lesions (27.8%) were positive for the dendritic cell marker DEC-205, compared to granulomas (9.0%, P<.05). Cavities contained significantly more T-regulatory cells (14.8%) than found in lipid pneumonia (5.2%) or granulomas (4.8%). Distribution of the immune cell types may contribute to the inability of the immune system to eradicate tuberculosis. |
| format | Article |
| id | doaj-art-4f8a15af9f394309b956beb271977c7f |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-4f8a15af9f394309b956beb271977c7f2025-02-03T05:58:45ZengWileyClinical and Developmental Immunology1740-25221740-25302011-01-01201110.1155/2011/307631307631Immunopathology of Postprimary Tuberculosis: Increased T-Regulatory Cells and DEC-205-Positive Foamy Macrophages in Cavitary LesionsKerry J. Welsh0Semyon A. Risin1Jeffrey K. Actor2Robert L. Hunter3Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, 6431 Fannin, MSB 2.136, Houston, TX 77030, USADepartment of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, 6431 Fannin, MSB 2.136, Houston, TX 77030, USADepartment of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, 6431 Fannin, MSB 2.136, Houston, TX 77030, USADepartment of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, 6431 Fannin, MSB 2.136, Houston, TX 77030, USAPostprimary tuberculosis occurs in immunocompetent people infected with Mycobacterium tuberculosis. It is restricted to the lung and accounts for 80% of cases and nearly 100% of transmission. Little is known about the immunopathology of postprimary tuberculosis due to limited availability of specimens. Tissues from 30 autopsy cases of pulmonary tuberculosis were located. Sections of characteristic lesions of caseating granulomas, lipid pneumonia, and cavitary stages of postprimary disease were selected for immunohistochemical studies of macrophages, lymphocytes, endothelial cells, and mycobacterial antigens. A higher percentage of cells in lipid pneumonia (36.1%) and cavitary lesions (27.8%) were positive for the dendritic cell marker DEC-205, compared to granulomas (9.0%, P<.05). Cavities contained significantly more T-regulatory cells (14.8%) than found in lipid pneumonia (5.2%) or granulomas (4.8%). Distribution of the immune cell types may contribute to the inability of the immune system to eradicate tuberculosis.http://dx.doi.org/10.1155/2011/307631 |
| spellingShingle | Kerry J. Welsh Semyon A. Risin Jeffrey K. Actor Robert L. Hunter Immunopathology of Postprimary Tuberculosis: Increased T-Regulatory Cells and DEC-205-Positive Foamy Macrophages in Cavitary Lesions Clinical and Developmental Immunology |
| title | Immunopathology of Postprimary Tuberculosis: Increased T-Regulatory Cells and DEC-205-Positive Foamy Macrophages in Cavitary Lesions |
| title_full | Immunopathology of Postprimary Tuberculosis: Increased T-Regulatory Cells and DEC-205-Positive Foamy Macrophages in Cavitary Lesions |
| title_fullStr | Immunopathology of Postprimary Tuberculosis: Increased T-Regulatory Cells and DEC-205-Positive Foamy Macrophages in Cavitary Lesions |
| title_full_unstemmed | Immunopathology of Postprimary Tuberculosis: Increased T-Regulatory Cells and DEC-205-Positive Foamy Macrophages in Cavitary Lesions |
| title_short | Immunopathology of Postprimary Tuberculosis: Increased T-Regulatory Cells and DEC-205-Positive Foamy Macrophages in Cavitary Lesions |
| title_sort | immunopathology of postprimary tuberculosis increased t regulatory cells and dec 205 positive foamy macrophages in cavitary lesions |
| url | http://dx.doi.org/10.1155/2011/307631 |
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