The heterogeneous sensitivity of pediatric brain tumors to different oncolytic viruses is predicted by unique gene expression profiles

The heterogeneous sensitivity of pediatric brain tumors to different oncolytic viruses is predicted by unique gene expression profiles

Despite decades of research, the prognosis of high-grade pediatric brain tumors (PBTs) remains dismal; however, recent cases of favorable clinical responses were documented in clinical trials using oncolytic viruses (OVs). In the current study, we employed four different species of OVs: adenovirus D...

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Main Authors: Konstantinos Vazaios, Εftychia Stavrakaki, Lisette B. Vogelezang, Jie Ju, Piotr Waranecki, Dennis S. Metselaar, Michaël H. Meel, Vera Kemp, Bernadette G. van den Hoogen, Rob C. Hoeben, E. Antonio Chiocca, William F. Goins, Andrew Stubbs, Yunlei Li, Marta M. Alonso, Friso G. Calkoen, Esther Hulleman, Jasper van der Lugt, Martine L.M. Lamfers
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Molecular Therapy: Oncology
Subjects:
MT: Regular Issue
pediatric brain tumors
oncolytic viruses
sensitivity
resistance
Gene Ontology
Online Access:http://www.sciencedirect.com/science/article/pii/S2950329924000468
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