Associations between muscle quality and whole-body vibration exercise-induced changes in plasma hypoxanthine following an oral glucose load in healthy male subjects
Blood levels of hypoxanthine (HX) have been suggested as potential biomarkers associated with intramuscular metabolic dynamics in response to exercise. This pilot randomized crossover trial (UMIN000036520) aimed to investigate the changes in plasma HX after whole-body vibration exercise (WBVE) and t...
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| Language: | English |
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The Japan Endocrine Society
2025-02-01
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| Series: | Endocrine Journal |
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| Online Access: | https://www.jstage.jst.go.jp/article/endocrj/72/2/72_EJ24-0358/_html/-char/en |
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| author | Tomoyuki Hara Yuya Fujishima Hitoshi Nishizawa Yusuke Kawachi Takashi Nakamura Seigo Akari Yoshiyuki Ono Hirotaka Watanabe Taka-aki Sakaue Yoshinari Obata Hirofumi Nagao Shiro Fukuda Takashi Kanamoto Mitsuyoshi Takahara Naoto Katakami Ken Nakata Iichiro Shimomura |
| author_facet | Tomoyuki Hara Yuya Fujishima Hitoshi Nishizawa Yusuke Kawachi Takashi Nakamura Seigo Akari Yoshiyuki Ono Hirotaka Watanabe Taka-aki Sakaue Yoshinari Obata Hirofumi Nagao Shiro Fukuda Takashi Kanamoto Mitsuyoshi Takahara Naoto Katakami Ken Nakata Iichiro Shimomura |
| author_sort | Tomoyuki Hara |
| collection | DOAJ |
| description | Blood levels of hypoxanthine (HX) have been suggested as potential biomarkers associated with intramuscular metabolic dynamics in response to exercise. This pilot randomized crossover trial (UMIN000036520) aimed to investigate the changes in plasma HX after whole-body vibration exercise (WBVE) and their relationships with body composition and muscle-related parameters, enrolling eighteen healthy male volunteers. In the WBVE-alone intervention, the study subjects performed 20-min of WBVE. In the OGTT → WBVE intervention, a 75-g oral glucose load (OGL) was administered 30 min prior to the start of the WBVE intervention. Blood samples were collected before the start and 10 min after the end of WBVE in both interventions. WBVE resulted in a significant increase in plasma HX levels, which was accompanied by increased blood ammonia, pyruvic acid, and lactic acid levels. The HX increase following WBVE was suppressed by prior OGL. In the WBVE-alone intervention, there were no significant correlations between the post-WBVE changes in plasma HX (ΔHX) levels and any of the clinical parameters. On the other hand, in the OGTT → WBVE intervention, ΔHX showed significant negative correlations with muscle mass (ρ = –0.62, p = 0.01), strength (ρ = –0.71, p = 0.005), and muscle quality (ρ = –0.81, p = 0.0007) in the legs. In conclusion, these findings suggest possible associations between post-WBVE increases in plasma HX levels and muscle status, particularly under the glucose-supplemented condition. The measurement of plasma HX concentrations following WBVE may have clinical applications in the identification of high-risk populations for sarcopenia. |
| format | Article |
| id | doaj-art-4f88b2de0adb4042ae1b14a374405743 |
| institution | Kabale University |
| issn | 1348-4540 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | The Japan Endocrine Society |
| record_format | Article |
| series | Endocrine Journal |
| spelling | doaj-art-4f88b2de0adb4042ae1b14a3744057432025-02-03T01:08:32ZengThe Japan Endocrine SocietyEndocrine Journal1348-45402025-02-0172217118110.1507/endocrj.EJ24-0358endocrjAssociations between muscle quality and whole-body vibration exercise-induced changes in plasma hypoxanthine following an oral glucose load in healthy male subjectsTomoyuki Hara0Yuya Fujishima1Hitoshi Nishizawa2Yusuke Kawachi3Takashi Nakamura4Seigo Akari5Yoshiyuki Ono6Hirotaka Watanabe7Taka-aki Sakaue8Yoshinari Obata9Hirofumi Nagao10Shiro Fukuda11Takashi Kanamoto12Mitsuyoshi Takahara13Naoto Katakami14Ken Nakata15Iichiro Shimomura16Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka 565-0871, JapanDepartment of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka 565-0871, JapanDepartment of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka 565-0871, JapanDepartment of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka 565-0871, JapanMedical Affairs Department, Sanwa Kagaku Kenkyusho Co., Ltd., Aichi 461-8631, JapanMedical Affairs Department, Sanwa Kagaku Kenkyusho Co., Ltd., Aichi 461-8631, JapanMedical Affairs Department, Sanwa Kagaku Kenkyusho Co., Ltd., Aichi 461-8631, JapanDepartment of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka 565-0871, JapanDepartment of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka 565-0871, JapanDepartment of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka 565-0871, JapanDepartment of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka 565-0871, JapanDepartment of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka 565-0871, JapanDepartment of Health and Sport Sciences, Graduate School of Medicine, Osaka University, Osaka 565-0871, JapanDepartment of Laboratory Medicine, Graduate School of Medicine, Osaka University, Osaka 565-0871, JapanDepartment of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka 565-0871, JapanDepartment of Health and Sport Sciences, Graduate School of Medicine, Osaka University, Osaka 565-0871, JapanDepartment of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka 565-0871, JapanBlood levels of hypoxanthine (HX) have been suggested as potential biomarkers associated with intramuscular metabolic dynamics in response to exercise. This pilot randomized crossover trial (UMIN000036520) aimed to investigate the changes in plasma HX after whole-body vibration exercise (WBVE) and their relationships with body composition and muscle-related parameters, enrolling eighteen healthy male volunteers. In the WBVE-alone intervention, the study subjects performed 20-min of WBVE. In the OGTT → WBVE intervention, a 75-g oral glucose load (OGL) was administered 30 min prior to the start of the WBVE intervention. Blood samples were collected before the start and 10 min after the end of WBVE in both interventions. WBVE resulted in a significant increase in plasma HX levels, which was accompanied by increased blood ammonia, pyruvic acid, and lactic acid levels. The HX increase following WBVE was suppressed by prior OGL. In the WBVE-alone intervention, there were no significant correlations between the post-WBVE changes in plasma HX (ΔHX) levels and any of the clinical parameters. On the other hand, in the OGTT → WBVE intervention, ΔHX showed significant negative correlations with muscle mass (ρ = –0.62, p = 0.01), strength (ρ = –0.71, p = 0.005), and muscle quality (ρ = –0.81, p = 0.0007) in the legs. In conclusion, these findings suggest possible associations between post-WBVE increases in plasma HX levels and muscle status, particularly under the glucose-supplemented condition. The measurement of plasma HX concentrations following WBVE may have clinical applications in the identification of high-risk populations for sarcopenia.https://www.jstage.jst.go.jp/article/endocrj/72/2/72_EJ24-0358/_html/-char/enwhole-body vibration exercisehypoxanthineskeletal muscleglucose metabolism |
| spellingShingle | Tomoyuki Hara Yuya Fujishima Hitoshi Nishizawa Yusuke Kawachi Takashi Nakamura Seigo Akari Yoshiyuki Ono Hirotaka Watanabe Taka-aki Sakaue Yoshinari Obata Hirofumi Nagao Shiro Fukuda Takashi Kanamoto Mitsuyoshi Takahara Naoto Katakami Ken Nakata Iichiro Shimomura Associations between muscle quality and whole-body vibration exercise-induced changes in plasma hypoxanthine following an oral glucose load in healthy male subjects Endocrine Journal whole-body vibration exercise hypoxanthine skeletal muscle glucose metabolism |
| title | Associations between muscle quality and whole-body vibration exercise-induced changes in plasma hypoxanthine following an oral glucose load in healthy male subjects |
| title_full | Associations between muscle quality and whole-body vibration exercise-induced changes in plasma hypoxanthine following an oral glucose load in healthy male subjects |
| title_fullStr | Associations between muscle quality and whole-body vibration exercise-induced changes in plasma hypoxanthine following an oral glucose load in healthy male subjects |
| title_full_unstemmed | Associations between muscle quality and whole-body vibration exercise-induced changes in plasma hypoxanthine following an oral glucose load in healthy male subjects |
| title_short | Associations between muscle quality and whole-body vibration exercise-induced changes in plasma hypoxanthine following an oral glucose load in healthy male subjects |
| title_sort | associations between muscle quality and whole body vibration exercise induced changes in plasma hypoxanthine following an oral glucose load in healthy male subjects |
| topic | whole-body vibration exercise hypoxanthine skeletal muscle glucose metabolism |
| url | https://www.jstage.jst.go.jp/article/endocrj/72/2/72_EJ24-0358/_html/-char/en |
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