A study on the relationship between depression, treatment side effects, and marital quality in cervical cancer patients undergoing radiotherapy and chemotherapy (宫颈癌放化疗患者抑郁与治疗副反应和婚姻质量的关系研究)
Objective To explore the relationship between depression and treatment side effects and marital quality in patients undergoing radiotherapy and or chemotherapy for cervical cancer, as well as the moderating role of neurotic personality and quality of life in this relationship, in order to provide a...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Journal of International Translational Medicine Limited
2025-07-01
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| Series: | 中西医结合护理 |
| Subjects: | |
| Online Access: | http://www.zxyjhhl.hk/thesisDetails#10.55111/j.issn2709-1961.20250613106 |
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| Summary: | Objective To explore the relationship between depression and treatment side effects and marital quality in patients undergoing radiotherapy and or chemotherapy for cervical cancer, as well as the moderating role of neurotic personality and quality of life in this relationship, in order to provide a theoretical basis for the prevention of and intervention in patients' depression. Methods The Patient-Reported Outcome Version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE), the Functional Assessment of Cervical Cancer Therapy Scale (FACT-Cx), the 9-entry Patient Health Questionnaire (PHQ-9), the Big Five personality neuroticism subscale (NEO-FFIN), and the short version of the Marital Adjustment and Prediction Scale (Locke-Wallace) were used to conduct a cross-sectional survey of 1053 cervical cancer patients. Results Depression in cervical cancer patients treated with radiotherapy was significantly and positively correlated with treatment side-effects and neurotic personality (P＜0. 01), and significantly and negatively correlated with marital relationship and quality of life (P＜0. 01). Analysis of structural equation modelling indicated that the relationship between treatment side-effects and depression in patients treated with radiotherapy and or chemotherapy for cervical cancer was moderated by the role of neurotic personality and quality of life, and was not mediated by the role of marital relationship. Conclusion It is necessary to routinely screen cervical cancer patients for psychological problems, pay attention to the important influence of radiotherapy treatment side effects on depression, and carry out targeted preventive and curative measures according to the different levels of neurotic personality and quality of life, in order to prevent and treat depression in cervical cancer patients more effectively. (目的 探讨宫颈癌放化疗患者抑郁与治疗副反应和婚姻质量之间的关系, 以及神经质人格、生活质量在这关系中的调节作用, 为预防和干预患者抑郁提供理论依据。方法 采用不良事件通用术语标准患者报告结果版本(PRO-CTCAE)、宫颈癌治疗功能评价量表(FACT-Cx)、九条目患者健康问卷(PHQ-9)、大五人格神经质分量表(NEO-FFIN)、简版婚姻调适与预测量表(Locke-Wallace)对1053例宫颈癌患者进行横断面调查。结果 放化疗宫颈癌患者抑郁与治疗副反应、神经质人格呈显著正相关(P＜0. 01), 与婚姻关系、生活质量呈显著负相关(P＜0. 01); 结构方程模型分析表明, 治疗副反应与宫颈癌放化疗患者抑郁间的关系受到神经质人格和生活质量的调节作用, 不受婚姻关系的中介作用。结论 需常规筛查宫颈癌患者的心理问题, 关注放化疗治疗副反应对抑郁的重要影响, 根据神经质人格和生活质量水平的不同开展针对性的防治措施, 以更有效地预防和治疗宫颈癌患者抑郁。) |
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| ISSN: | 2709-1961 |