Therapeutic effects of epigallocatechin and epigallocatechin gallate on the allergic reaction of αs1-casein sensitized mice
To investigate the anti-αs1-casein allergy mechanism of two tea-derived polyphenols, epigallocatechin (EGC) and epigallocatechin gallate (EGCG), BALB/c mice were sensitized and challenged with αs1-casein and nutritional intervention was given by EGC and EGCG during the sensitization provocation phas...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2023-05-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453022002051 |
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| author | Qianqian Zhang Xiaofeng Yu Linghan Tian Yanjun Cong Linfeng Li |
| author_facet | Qianqian Zhang Xiaofeng Yu Linghan Tian Yanjun Cong Linfeng Li |
| author_sort | Qianqian Zhang |
| collection | DOAJ |
| description | To investigate the anti-αs1-casein allergy mechanism of two tea-derived polyphenols, epigallocatechin (EGC) and epigallocatechin gallate (EGCG), BALB/c mice were sensitized and challenged with αs1-casein and nutritional intervention was given by EGC and EGCG during the sensitization provocation phase. The main evaluation indexes used were levels of mast cell proteases, histamine, and specific antibody immunoglobulin E (IgE), as well as cytokine secretion and pathological observation. The results showed that both EGC and EGCG significantly reduced levels of mast cell protease, histamine, specific IgE antibodies, and Th2 cytokines in allergic mice. The histopathology results showed that both EGC and EGCG markedly reduced the degree of lesions in the intestine, thymus, spleen, and lung. The conclusions from this study can provide a theoretical basis for the mechanism by which tea polyphenols regulate food allergens. |
| format | Article |
| id | doaj-art-4f790b8fd4014b86ab52c415270cba56 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2023-05-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-4f790b8fd4014b86ab52c415270cba562025-02-03T10:34:08ZengTsinghua University PressFood Science and Human Wellness2213-45302023-05-01123882888Therapeutic effects of epigallocatechin and epigallocatechin gallate on the allergic reaction of αs1-casein sensitized miceQianqian Zhang0Xiaofeng Yu1Linghan Tian2Yanjun Cong3Linfeng Li4Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food and Health, Beijing Technology and Business University, Beijing 100048, ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food and Health, Beijing Technology and Business University, Beijing 100048, ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food and Health, Beijing Technology and Business University, Beijing 100048, ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food and Health, Beijing Technology and Business University, Beijing 100048, China; Corresponding author at: College of Food and Health, Beijing Technology and Business University, Beijing 100048, China.Department of Dermatology, Beijing Friendship Hospital, Beijing 100050, ChinaTo investigate the anti-αs1-casein allergy mechanism of two tea-derived polyphenols, epigallocatechin (EGC) and epigallocatechin gallate (EGCG), BALB/c mice were sensitized and challenged with αs1-casein and nutritional intervention was given by EGC and EGCG during the sensitization provocation phase. The main evaluation indexes used were levels of mast cell proteases, histamine, and specific antibody immunoglobulin E (IgE), as well as cytokine secretion and pathological observation. The results showed that both EGC and EGCG significantly reduced levels of mast cell protease, histamine, specific IgE antibodies, and Th2 cytokines in allergic mice. The histopathology results showed that both EGC and EGCG markedly reduced the degree of lesions in the intestine, thymus, spleen, and lung. The conclusions from this study can provide a theoretical basis for the mechanism by which tea polyphenols regulate food allergens.http://www.sciencedirect.com/science/article/pii/S2213453022002051αs1-caseinEpigallocatechinEpigallocatechin gallateAntianaphylaxis |
| spellingShingle | Qianqian Zhang Xiaofeng Yu Linghan Tian Yanjun Cong Linfeng Li Therapeutic effects of epigallocatechin and epigallocatechin gallate on the allergic reaction of αs1-casein sensitized mice Food Science and Human Wellness αs1-casein Epigallocatechin Epigallocatechin gallate Antianaphylaxis |
| title | Therapeutic effects of epigallocatechin and epigallocatechin gallate on the allergic reaction of αs1-casein sensitized mice |
| title_full | Therapeutic effects of epigallocatechin and epigallocatechin gallate on the allergic reaction of αs1-casein sensitized mice |
| title_fullStr | Therapeutic effects of epigallocatechin and epigallocatechin gallate on the allergic reaction of αs1-casein sensitized mice |
| title_full_unstemmed | Therapeutic effects of epigallocatechin and epigallocatechin gallate on the allergic reaction of αs1-casein sensitized mice |
| title_short | Therapeutic effects of epigallocatechin and epigallocatechin gallate on the allergic reaction of αs1-casein sensitized mice |
| title_sort | therapeutic effects of epigallocatechin and epigallocatechin gallate on the allergic reaction of αs1 casein sensitized mice |
| topic | αs1-casein Epigallocatechin Epigallocatechin gallate Antianaphylaxis |
| url | http://www.sciencedirect.com/science/article/pii/S2213453022002051 |
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