A Silk Fibroin Nanoparticle Hydrogel Loaded With NK1R Antagonist Has Synergistic Anti‐Inflammatory and Reparative Effects on Dry Eye Disease

A Silk Fibroin Nanoparticle Hydrogel Loaded With NK1R Antagonist Has Synergistic Anti‐Inflammatory and Reparative Effects on Dry Eye Disease

Abstract Dry eye disease (DED) is a multifactorial illness affecting tears and the ocular surface. The neurokinin 1 receptor (NK1R) is a target for controlling T helper 17 (Th17) and regulatory T cell (Treg) imbalances. This work creates a silk fibroin (SF) nanoparticle hydrogel that targets NK1R wi...

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Bibliographic Details
Main Authors: Bo Gong, Yi Liu, Huan Li, Xueming Ju, Dongfeng Li, Yuhao Zou, Xiaoxin Guo, Kai Dong, Jialing Xiao, Weijia Wu, Renjie Chai, Ruifan Zhang, Man Yu
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Advanced Science
Subjects:
anti‐inflammatory
dry eye disease
NK1R antagonist
repair
silk fibroin nanoparticles
Online Access:https://doi.org/10.1002/advs.202404835
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