The Association between Chronic Arsenic Exposure and Hypertension: A Meta-Analysis
Background. There is inconclusive evidence from cross-sectional and cohort studies that arsenic exposure is a risk factor involved in the development of hypertension. Methods. A database search, using several keywords, was conducted to identify relevant studies. Separate odds ratio estimates for ars...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/2012/198793 |
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| _version_ | 1832545709903052800 |
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| author | Tanvir Abir Bayzidur Rahman Catherine D'Este Abdulaziz Farooq Abul Hasnat Milton |
| author_facet | Tanvir Abir Bayzidur Rahman Catherine D'Este Abdulaziz Farooq Abul Hasnat Milton |
| author_sort | Tanvir Abir |
| collection | DOAJ |
| description | Background. There is inconclusive evidence from cross-sectional and cohort studies that arsenic exposure is a risk factor involved in the development of hypertension. Methods. A database search, using several keywords, was conducted to identify relevant studies. Separate odds ratio estimates for arsenic exposure with concentration only and arsenic exposure with duration, including biomarker, were extracted from studies that met all inclusion criteria. The extracted odds ratios (OR) comparing the highest exposure categories with the lowest in each study were pooled using the random effects methods of meta-analysis. Heterogeneity of odds ratios in the included studies were analyzed using I2 statistics. Results. Eight studies were analyzed. Using the exposure as arsenic concentration in the drinking water, the OR estimate was 1.9 (95% CI: 1.2–3.0), with the I2 = 92%, while using the exposure as concentration and duration, the OR estimate was 1.4 (95% CI: 0.95–2.0) with the I2 = 80%. Meta-regression was done and the quality of exposure measurement was found to be significantly associated with the effect measure. For a one unit increase in the score from exposure assessment, the odds ratio decreased by 6%. No publication bias was evident. The only major weaknesses of this study were heterogeneity across studies and small sample size. Conclusions. The study findings provide limited evidence for a relationship between arsenic and hypertension. In summary, the relationship between arsenic exposure and hypertension is still inconclusive and needs further validation through prospective cohort studies. |
| format | Article |
| id | doaj-art-4f6c12d742164429a614994a2c551cea |
| institution | Kabale University |
| issn | 1687-8191 1687-8205 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Toxicology |
| spelling | doaj-art-4f6c12d742164429a614994a2c551cea2025-02-03T07:24:58ZengWileyJournal of Toxicology1687-81911687-82052012-01-01201210.1155/2012/198793198793The Association between Chronic Arsenic Exposure and Hypertension: A Meta-AnalysisTanvir Abir0Bayzidur Rahman1Catherine D'Este2Abdulaziz Farooq3Abul Hasnat Milton4Centre for Clinical Epidemiology and Biostatistics (CCEB), The School of Medicine and Public Health, Faculty of Health, The University of Newcastle, Newcastle, NSW 2008, AustraliaThe School of Public Health and Community Medicine, Faculty of Medicine, The University of New South Wales, Sydney, NSW 2052, AustraliaBiostatistics, School of Medicine and Public Health, The University of Newcastle, Newcastle, NSW 2008, AustraliaResearch and Education Department, ASPETAR-Qatar Orthopaedic and Sports Medicine Hospital, P.O. Box 29992, Doha, QatarCentre for Clinical Epidemiology and Biostatistics (CCEB), The School of Medicine and Public Health, Faculty of Health, The University of Newcastle, Newcastle, NSW 2008, AustraliaBackground. There is inconclusive evidence from cross-sectional and cohort studies that arsenic exposure is a risk factor involved in the development of hypertension. Methods. A database search, using several keywords, was conducted to identify relevant studies. Separate odds ratio estimates for arsenic exposure with concentration only and arsenic exposure with duration, including biomarker, were extracted from studies that met all inclusion criteria. The extracted odds ratios (OR) comparing the highest exposure categories with the lowest in each study were pooled using the random effects methods of meta-analysis. Heterogeneity of odds ratios in the included studies were analyzed using I2 statistics. Results. Eight studies were analyzed. Using the exposure as arsenic concentration in the drinking water, the OR estimate was 1.9 (95% CI: 1.2–3.0), with the I2 = 92%, while using the exposure as concentration and duration, the OR estimate was 1.4 (95% CI: 0.95–2.0) with the I2 = 80%. Meta-regression was done and the quality of exposure measurement was found to be significantly associated with the effect measure. For a one unit increase in the score from exposure assessment, the odds ratio decreased by 6%. No publication bias was evident. The only major weaknesses of this study were heterogeneity across studies and small sample size. Conclusions. The study findings provide limited evidence for a relationship between arsenic and hypertension. In summary, the relationship between arsenic exposure and hypertension is still inconclusive and needs further validation through prospective cohort studies.http://dx.doi.org/10.1155/2012/198793 |
| spellingShingle | Tanvir Abir Bayzidur Rahman Catherine D'Este Abdulaziz Farooq Abul Hasnat Milton The Association between Chronic Arsenic Exposure and Hypertension: A Meta-Analysis Journal of Toxicology |
| title | The Association between Chronic Arsenic Exposure and Hypertension: A Meta-Analysis |
| title_full | The Association between Chronic Arsenic Exposure and Hypertension: A Meta-Analysis |
| title_fullStr | The Association between Chronic Arsenic Exposure and Hypertension: A Meta-Analysis |
| title_full_unstemmed | The Association between Chronic Arsenic Exposure and Hypertension: A Meta-Analysis |
| title_short | The Association between Chronic Arsenic Exposure and Hypertension: A Meta-Analysis |
| title_sort | association between chronic arsenic exposure and hypertension a meta analysis |
| url | http://dx.doi.org/10.1155/2012/198793 |
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