Distinct inflammation-related proteins associated with T cell immune recovery during chronic HIV-1 infection

Distinct inflammation-related proteins associated with T cell immune recovery during chronic HIV-1 infection

Chronic inflammation and T cell dysregulation persist in individuals infected with human immunodeficiency virus type 1 (HIV-1), even after successful antiretroviral treatment. The mechanism involved is not fully understood. Here, we used Olink proteomics to comprehensively analyze the aberrant infla...

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Main Authors: Lin-Yu Wan, Hui-Huang Huang, Cheng Zhen, Si-Yuan Chen, Bing Song, Wen-Jing Cao, Li-Li Shen, Ming-Ju Zhou, Xiao-Chang Zhang, Ruonan Xu, Xing Fan, Ji-Yuan Zhang, Ming Shi, Chao Zhang, Yan-Mei Jiao, Jin-Wen Song, Fu-Sheng Wang
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Emerging Microbes and Infections
Subjects:
HIV-1
Inflammation
HIV-1 reservoir
CXCL9
CXCL10
CXCL11
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2022.2150566
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Summary:Chronic inflammation and T cell dysregulation persist in individuals infected with human immunodeficiency virus type 1 (HIV-1), even after successful antiretroviral treatment. The mechanism involved is not fully understood. Here, we used Olink proteomics to comprehensively analyze the aberrant inflammation-related proteins (IRPs) in chronic HIV-1-infected individuals, including in 24 treatment-naïve individuals, 33 immunological responders, and 38 immunological non-responders. T cell dysfunction was evaluated as T cell exhaustion, activation, and differentiation using flow cytometry. We identified a cluster of IRPs (cluster 7), including CXCL11, CXCL9, TNF, CXCL10, and IL18, which was closely associated with T cell dysregulation during chronic HIV-1 infection. Interestingly, IRPs in cluster 5, including ST1A1, CASP8, SIRT2, AXIN1, STAMBP, CD40, and IL7, were negatively correlated with the HIV-1 reservoir size. We also identified a combination of CDCP1, CXCL11, CST5, SLAMF1, TRANCE, and CD5, which may be useful for distinguishing immunological responders and immunological non-responders. In conclusion, the distinct inflammatory milieu is closely associated with immune restoration of T cells, and our results provide insight into immune dysregulation during chronic HIV-1 infection.
ISSN:2222-1751

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