Study protocol for using a smartphone application to investigate speech biomarkers of Parkinson’s disease and other synucleinopathies: SMARTSPEECH
Introduction Early identification of Parkinson’s disease (PD) in its prodromal stage has fundamental implications for the future development of neuroprotective therapies. However, no sufficiently accurate biomarkers of prodromal PD are currently available to facilitate early identification. The voca...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2022-06-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/6/e059871.full |
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| author | Jan Rusz Tomáš Kouba Vojtěch Illner |
| author_facet | Jan Rusz Tomáš Kouba Vojtěch Illner |
| author_sort | Jan Rusz |
| collection | DOAJ |
| description | Introduction Early identification of Parkinson’s disease (PD) in its prodromal stage has fundamental implications for the future development of neuroprotective therapies. However, no sufficiently accurate biomarkers of prodromal PD are currently available to facilitate early identification. The vocal assessment of patients with isolated rapid eye movement sleep behaviour disorder (iRBD) and PD appears to have intriguing potential as a diagnostic and progressive biomarker of PD and related synucleinopathies.Methods and analysis Speech patterns in the spontaneous speech of iRBD, early PD and control participants’ voice calls will be collected from data acquired via a developed smartphone application over a period of 2 years. A significant increase in several aspects of PD-related speech disorders is expected, and is anticipated to reflect the underlying neurodegeneration processes.Ethics and dissemination The study has been approved by the Ethics Committee of the General University Hospital in Prague, Czech Republic and all the participants will provide written, informed consent prior to their inclusion in the research. The application satisfies the General Data Protection Regulation law requirements of the European Union. The study findings will be published in peer-reviewed journals and presented at international scientific conferences. |
| format | Article |
| id | doaj-art-4f375edb45fc4c9181c7b58c4d375b4d |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-4f375edb45fc4c9181c7b58c4d375b4d2025-01-24T15:00:14ZengBMJ Publishing GroupBMJ Open2044-60552022-06-0112610.1136/bmjopen-2021-059871Study protocol for using a smartphone application to investigate speech biomarkers of Parkinson’s disease and other synucleinopathies: SMARTSPEECHJan Rusz0Tomáš Kouba1Vojtěch Illner2Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech RepublicDepartment of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech RepublicDepartment of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech RepublicIntroduction Early identification of Parkinson’s disease (PD) in its prodromal stage has fundamental implications for the future development of neuroprotective therapies. However, no sufficiently accurate biomarkers of prodromal PD are currently available to facilitate early identification. The vocal assessment of patients with isolated rapid eye movement sleep behaviour disorder (iRBD) and PD appears to have intriguing potential as a diagnostic and progressive biomarker of PD and related synucleinopathies.Methods and analysis Speech patterns in the spontaneous speech of iRBD, early PD and control participants’ voice calls will be collected from data acquired via a developed smartphone application over a period of 2 years. A significant increase in several aspects of PD-related speech disorders is expected, and is anticipated to reflect the underlying neurodegeneration processes.Ethics and dissemination The study has been approved by the Ethics Committee of the General University Hospital in Prague, Czech Republic and all the participants will provide written, informed consent prior to their inclusion in the research. The application satisfies the General Data Protection Regulation law requirements of the European Union. The study findings will be published in peer-reviewed journals and presented at international scientific conferences.https://bmjopen.bmj.com/content/12/6/e059871.full |
| spellingShingle | Jan Rusz Tomáš Kouba Vojtěch Illner Study protocol for using a smartphone application to investigate speech biomarkers of Parkinson’s disease and other synucleinopathies: SMARTSPEECH BMJ Open |
| title | Study protocol for using a smartphone application to investigate speech biomarkers of Parkinson’s disease and other synucleinopathies: SMARTSPEECH |
| title_full | Study protocol for using a smartphone application to investigate speech biomarkers of Parkinson’s disease and other synucleinopathies: SMARTSPEECH |
| title_fullStr | Study protocol for using a smartphone application to investigate speech biomarkers of Parkinson’s disease and other synucleinopathies: SMARTSPEECH |
| title_full_unstemmed | Study protocol for using a smartphone application to investigate speech biomarkers of Parkinson’s disease and other synucleinopathies: SMARTSPEECH |
| title_short | Study protocol for using a smartphone application to investigate speech biomarkers of Parkinson’s disease and other synucleinopathies: SMARTSPEECH |
| title_sort | study protocol for using a smartphone application to investigate speech biomarkers of parkinson s disease and other synucleinopathies smartspeech |
| url | https://bmjopen.bmj.com/content/12/6/e059871.full |
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