Is prone sleeping dangerous for neonates? Polysomnographic characteristics and NDN gene analysis
Objective: Prone sleep is an identified risk factor for sudden infant death syndrome, possibly due to reduced blood pressure, cerebral oxygenation, and impaired cerebral vascular control. Cardiac and respiratory responses in neonates during supine and prone sleep have not been reported. Materials a...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2019-01-01
|
| Series: | Tzu Chi Medical Journal |
| Subjects: | |
| Online Access: | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2019;volume=31;issue=2;spage=113;epage=117;aulast=Wong |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849696723908165632 |
|---|---|
| author | Shi-Bing Wong Lu-Lu Zhao Shu-Hua Chuang Wen-Hsin Tsai Chun-Hsien Yu Li-Ping Tsai |
| author_facet | Shi-Bing Wong Lu-Lu Zhao Shu-Hua Chuang Wen-Hsin Tsai Chun-Hsien Yu Li-Ping Tsai |
| author_sort | Shi-Bing Wong |
| collection | DOAJ |
| description | Objective: Prone sleep is an identified risk factor for sudden infant death syndrome, possibly due to reduced blood pressure, cerebral oxygenation, and impaired cerebral vascular control. Cardiac and respiratory responses in neonates during supine and prone sleep have not been reported. Materials and Methods: In this study, daytime polysomnography (PSG) data from 17 neonates aged 2–3 days during supine and prone sleep were reported and the NDN gene, an important gene for neonatal respiratory control, was sequenced for correlation with neonatal respiratory parameters. Heart rate (HR), oxygen saturation, carbon dioxide concentration, sleep stages, central apnea index (CAI), obstructive apnea/hypopnea index (OAHI), and oxygen nadir were compared between supine and prone sleep and between participants with different single-nucleotide polymorphisms (SNPs) in the NDN gene. Results: During prone sleep, neonates had a faster HR, decreased oxygen saturation, and a longer duration of oxygen saturation <90% than during supine sleep, suggesting that cardiopulmonary responsiveness was impaired. Sleep efficiency, sleep stages, oxygen nadir, and carbon dioxide tension were not different during supine and prone sleep. Central apnea occurred more significantly than obstructive apnea. During supine and prone sleep, the CAI was 3.3 ± 2.9/h and 2.3 ± 2.6/h and the OAHI was 0.6 ± 0.7/h and 0.6 ± 0.8/h, respectively. We found one SNP rs3743340 in the NDN gene that had no effect on the sleep and respiratory parameters of PSG. Conclusion: Tachycardia and respiratory instability were recorded in neonates during prone sleep, suggesting that neonates are vulnerable to cardiopulmonary events during prone sleep. Therefore, young neonates should be kept in the supine sleep position unless there are contraindications. |
| format | Article |
| id | doaj-art-4f30c12b0e5f4c15a72b07a842ee70ce |
| institution | DOAJ |
| issn | 1016-3190 2223-8956 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Tzu Chi Medical Journal |
| spelling | doaj-art-4f30c12b0e5f4c15a72b07a842ee70ce2025-08-20T03:19:23ZengWolters Kluwer Medknow PublicationsTzu Chi Medical Journal1016-31902223-89562019-01-0131211311710.4103/tcmj.tcmj_29_18Is prone sleeping dangerous for neonates? Polysomnographic characteristics and NDN gene analysisShi-Bing WongLu-Lu ZhaoShu-Hua ChuangWen-Hsin TsaiChun-Hsien YuLi-Ping TsaiObjective: Prone sleep is an identified risk factor for sudden infant death syndrome, possibly due to reduced blood pressure, cerebral oxygenation, and impaired cerebral vascular control. Cardiac and respiratory responses in neonates during supine and prone sleep have not been reported. Materials and Methods: In this study, daytime polysomnography (PSG) data from 17 neonates aged 2–3 days during supine and prone sleep were reported and the NDN gene, an important gene for neonatal respiratory control, was sequenced for correlation with neonatal respiratory parameters. Heart rate (HR), oxygen saturation, carbon dioxide concentration, sleep stages, central apnea index (CAI), obstructive apnea/hypopnea index (OAHI), and oxygen nadir were compared between supine and prone sleep and between participants with different single-nucleotide polymorphisms (SNPs) in the NDN gene. Results: During prone sleep, neonates had a faster HR, decreased oxygen saturation, and a longer duration of oxygen saturation <90% than during supine sleep, suggesting that cardiopulmonary responsiveness was impaired. Sleep efficiency, sleep stages, oxygen nadir, and carbon dioxide tension were not different during supine and prone sleep. Central apnea occurred more significantly than obstructive apnea. During supine and prone sleep, the CAI was 3.3 ± 2.9/h and 2.3 ± 2.6/h and the OAHI was 0.6 ± 0.7/h and 0.6 ± 0.8/h, respectively. We found one SNP rs3743340 in the NDN gene that had no effect on the sleep and respiratory parameters of PSG. Conclusion: Tachycardia and respiratory instability were recorded in neonates during prone sleep, suggesting that neonates are vulnerable to cardiopulmonary events during prone sleep. Therefore, young neonates should be kept in the supine sleep position unless there are contraindications.http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2019;volume=31;issue=2;spage=113;epage=117;aulast=WongHeart rateNDNSleep apneaSleeping positionSudden infant death syndrome |
| spellingShingle | Shi-Bing Wong Lu-Lu Zhao Shu-Hua Chuang Wen-Hsin Tsai Chun-Hsien Yu Li-Ping Tsai Is prone sleeping dangerous for neonates? Polysomnographic characteristics and NDN gene analysis Tzu Chi Medical Journal Heart rate NDN Sleep apnea Sleeping position Sudden infant death syndrome |
| title | Is prone sleeping dangerous for neonates? Polysomnographic characteristics and NDN gene analysis |
| title_full | Is prone sleeping dangerous for neonates? Polysomnographic characteristics and NDN gene analysis |
| title_fullStr | Is prone sleeping dangerous for neonates? Polysomnographic characteristics and NDN gene analysis |
| title_full_unstemmed | Is prone sleeping dangerous for neonates? Polysomnographic characteristics and NDN gene analysis |
| title_short | Is prone sleeping dangerous for neonates? Polysomnographic characteristics and NDN gene analysis |
| title_sort | is prone sleeping dangerous for neonates polysomnographic characteristics and ndn gene analysis |
| topic | Heart rate NDN Sleep apnea Sleeping position Sudden infant death syndrome |
| url | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2019;volume=31;issue=2;spage=113;epage=117;aulast=Wong |
| work_keys_str_mv | AT shibingwong ispronesleepingdangerousforneonatespolysomnographiccharacteristicsandndngeneanalysis AT luluzhao ispronesleepingdangerousforneonatespolysomnographiccharacteristicsandndngeneanalysis AT shuhuachuang ispronesleepingdangerousforneonatespolysomnographiccharacteristicsandndngeneanalysis AT wenhsintsai ispronesleepingdangerousforneonatespolysomnographiccharacteristicsandndngeneanalysis AT chunhsienyu ispronesleepingdangerousforneonatespolysomnographiccharacteristicsandndngeneanalysis AT lipingtsai ispronesleepingdangerousforneonatespolysomnographiccharacteristicsandndngeneanalysis |