The influence of cyclothymic and hyperthymic affective temperaments on glycemic control in patients with type 2 diabetes
Abstract Affective temperaments are inherited parts of personality determining mood and activity, affecting the management of somatic conditions. We aimed to investigate the association between affective temperaments, depressive symptoms, and self-care (physical activity, smoking, alcohol consumptio...
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Nature Portfolio
2025-02-01
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| Online Access: | https://doi.org/10.1038/s41598-025-90292-w |
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| author | Csenge Hargittay Krisztián Vörös Ajándék Eőry Andrea László Bernadett Márkus Georgina Szabó Bálint Tripolszky Zoltán Rihmer Xénia Gonda Péter Torzsa |
| author_facet | Csenge Hargittay Krisztián Vörös Ajándék Eőry Andrea László Bernadett Márkus Georgina Szabó Bálint Tripolszky Zoltán Rihmer Xénia Gonda Péter Torzsa |
| author_sort | Csenge Hargittay |
| collection | DOAJ |
| description | Abstract Affective temperaments are inherited parts of personality determining mood and activity, affecting the management of somatic conditions. We aimed to investigate the association between affective temperaments, depressive symptoms, and self-care (physical activity, smoking, alcohol consumption), and their effect on glycemic control, among patients with type 2 diabetes (T2DM) in general practice, in a cross-sectional study enrolling 338 consecutive patients from six primary care practices in Hungary. A self-administered questionnaire (history, anthropometric, socioeconomic, laboratory parameters), the Beck Depression Inventory (BDI), the Hamilton Anxiety Scale, and the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Autoquestionnaire were used. Cyclothymic affective temperament determined HbA1c levels in regression analysis (p = 0.002), and the BDI score (p = 0.048). In causal mediation analyses, cyclothymic affective temperament was directly associated with higher HbA1c (p = 0.008). Hyperthymic affective temperament was indirectly associated with lower HbA1c, mediated by BDI (p = 0.034). Depressive, anxious, and irritable affective temperaments, and lifestyle factors were not associated with HbA1c neither in regression nor in mediation analysis as direct or mediating factors. Among primary care patients with T2DM, cyclothymic temperament correlates with worse glycemic control, independently of depressive symptoms. Hyperthymic temperament reduces depressive symptoms, thereby improving glycemic control. Identifying affective temperaments may improve diabetes care. |
| format | Article |
| id | doaj-art-4f2b46aa0eb043d0a8e7c862f4bb03e2 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-4f2b46aa0eb043d0a8e7c862f4bb03e22025-08-20T03:10:50ZengNature PortfolioScientific Reports2045-23222025-02-011511810.1038/s41598-025-90292-wThe influence of cyclothymic and hyperthymic affective temperaments on glycemic control in patients with type 2 diabetesCsenge Hargittay0Krisztián Vörös1Ajándék Eőry2Andrea László3Bernadett Márkus4Georgina Szabó5Bálint Tripolszky6Zoltán Rihmer7Xénia Gonda8Péter Torzsa9Department of Family Medicine, Faculty of Medicine, Semmelweis UniversityDepartment of Family Medicine, Faculty of Medicine, Semmelweis UniversityDepartment of Family Medicine, Faculty of Medicine, Semmelweis UniversityNorisana - MVZ RosenauDepartment of Family Medicine, Faculty of Medicine, Semmelweis UniversityDoctoral School of Mental Health Sciences, Semmelweis UniversityDepartment of Family Medicine, Faculty of Medicine, Semmelweis UniversityDepartment of Psychiatry and Psychotherapy, Faculty of Medicine, Semmelweis UniversityDepartment of Psychiatry and Psychotherapy, Faculty of Medicine, Semmelweis UniversityDepartment of Family Medicine, Faculty of Medicine, Semmelweis UniversityAbstract Affective temperaments are inherited parts of personality determining mood and activity, affecting the management of somatic conditions. We aimed to investigate the association between affective temperaments, depressive symptoms, and self-care (physical activity, smoking, alcohol consumption), and their effect on glycemic control, among patients with type 2 diabetes (T2DM) in general practice, in a cross-sectional study enrolling 338 consecutive patients from six primary care practices in Hungary. A self-administered questionnaire (history, anthropometric, socioeconomic, laboratory parameters), the Beck Depression Inventory (BDI), the Hamilton Anxiety Scale, and the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Autoquestionnaire were used. Cyclothymic affective temperament determined HbA1c levels in regression analysis (p = 0.002), and the BDI score (p = 0.048). In causal mediation analyses, cyclothymic affective temperament was directly associated with higher HbA1c (p = 0.008). Hyperthymic affective temperament was indirectly associated with lower HbA1c, mediated by BDI (p = 0.034). Depressive, anxious, and irritable affective temperaments, and lifestyle factors were not associated with HbA1c neither in regression nor in mediation analysis as direct or mediating factors. Among primary care patients with T2DM, cyclothymic temperament correlates with worse glycemic control, independently of depressive symptoms. Hyperthymic temperament reduces depressive symptoms, thereby improving glycemic control. Identifying affective temperaments may improve diabetes care.https://doi.org/10.1038/s41598-025-90292-wType 2 diabetesAffective temperamentsDepressive symptomsMediating factorsPrimary care |
| spellingShingle | Csenge Hargittay Krisztián Vörös Ajándék Eőry Andrea László Bernadett Márkus Georgina Szabó Bálint Tripolszky Zoltán Rihmer Xénia Gonda Péter Torzsa The influence of cyclothymic and hyperthymic affective temperaments on glycemic control in patients with type 2 diabetes Scientific Reports Type 2 diabetes Affective temperaments Depressive symptoms Mediating factors Primary care |
| title | The influence of cyclothymic and hyperthymic affective temperaments on glycemic control in patients with type 2 diabetes |
| title_full | The influence of cyclothymic and hyperthymic affective temperaments on glycemic control in patients with type 2 diabetes |
| title_fullStr | The influence of cyclothymic and hyperthymic affective temperaments on glycemic control in patients with type 2 diabetes |
| title_full_unstemmed | The influence of cyclothymic and hyperthymic affective temperaments on glycemic control in patients with type 2 diabetes |
| title_short | The influence of cyclothymic and hyperthymic affective temperaments on glycemic control in patients with type 2 diabetes |
| title_sort | influence of cyclothymic and hyperthymic affective temperaments on glycemic control in patients with type 2 diabetes |
| topic | Type 2 diabetes Affective temperaments Depressive symptoms Mediating factors Primary care |
| url | https://doi.org/10.1038/s41598-025-90292-w |
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