Efficacy and safety of Saireito (TJ-114) in patients with atrial fibrillation undergoing catheter ablation procedures: A randomized pilot study.
<h4>Background</h4>Early arrhythmia recurrences commonly occur after atrial fibrillation (AF) ablation because of irritability and inflammation of left atrium. We hypothesized that short-term use of Saireito would be effective in reducing frequent atrial tachyarrhythmias in the early-pha...
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Public Library of Science (PLoS)
2024-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0307854 |
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| author | Tetsuma Kawaji Satoshi Shizuta Hidenori Yaku Kazuhisa Kaneda Fumiya Yoneda Shushi Nishiwaki Munekazu Tanaka Takanori Aizawa Shun Hojo Kenji Nakatsuma Masashi Kato Takafumi Yokomatsu Shinji Miki Koh Ono Takeshi Kimura |
| author_facet | Tetsuma Kawaji Satoshi Shizuta Hidenori Yaku Kazuhisa Kaneda Fumiya Yoneda Shushi Nishiwaki Munekazu Tanaka Takanori Aizawa Shun Hojo Kenji Nakatsuma Masashi Kato Takafumi Yokomatsu Shinji Miki Koh Ono Takeshi Kimura |
| author_sort | Tetsuma Kawaji |
| collection | DOAJ |
| description | <h4>Background</h4>Early arrhythmia recurrences commonly occur after atrial fibrillation (AF) ablation because of irritability and inflammation of left atrium. We hypothesized that short-term use of Saireito would be effective in reducing frequent atrial tachyarrhythmias in the early-phase post-ablation.<h4>Methods</h4>One hundred patients undergoing catheter ablation for symptomatic AF were randomly assigned to either a 30-day use of Saireito or control group. The primary endpoint was total number of episodes of frequent atrial tachyarrhythmias including definite recurrent AF and frequent premature atrial contractions during the 30-day treatment period post-ablation.<h4>Results</h4>Three (6.0%) out of 50 patients treated with Saireito discontinued the drug because of adverse symptoms. The Saireito group was associated with a numerically lower number of episodes of frequent atrial tachyarrhythmias than the control group (3.1 versus 5.2 times, P = 0.17). The mean daily episodes of frequent atrial tachyarrhythmias were significantly fewer in the Saireito group during Day-6 to Day-10 (0.12/day versus 0.27/day, P = 0.03), and during Day-11 to Day-15 (0.08/day versus 0.24/day, P = 0.001). The prevalence of adverse symptoms during the 30-day treatment period was significantly higher in the Saireito group (18.0% versus 2.0%, P = 0.005).<h4>Conclusions</h4>Thirty-day use of Saireito following AF ablation was associated with a tendency toward reduced number of episodes of frequent atrial tachyarrhythmias during the treatment period, with more pronounced effect in the first two weeks. |
| format | Article |
| id | doaj-art-4f1f6b3ff64143ef927ce31db7f20030 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-4f1f6b3ff64143ef927ce31db7f200302025-01-29T05:30:47ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-01198e030785410.1371/journal.pone.0307854Efficacy and safety of Saireito (TJ-114) in patients with atrial fibrillation undergoing catheter ablation procedures: A randomized pilot study.Tetsuma KawajiSatoshi ShizutaHidenori YakuKazuhisa KanedaFumiya YonedaShushi NishiwakiMunekazu TanakaTakanori AizawaShun HojoKenji NakatsumaMasashi KatoTakafumi YokomatsuShinji MikiKoh OnoTakeshi Kimura<h4>Background</h4>Early arrhythmia recurrences commonly occur after atrial fibrillation (AF) ablation because of irritability and inflammation of left atrium. We hypothesized that short-term use of Saireito would be effective in reducing frequent atrial tachyarrhythmias in the early-phase post-ablation.<h4>Methods</h4>One hundred patients undergoing catheter ablation for symptomatic AF were randomly assigned to either a 30-day use of Saireito or control group. The primary endpoint was total number of episodes of frequent atrial tachyarrhythmias including definite recurrent AF and frequent premature atrial contractions during the 30-day treatment period post-ablation.<h4>Results</h4>Three (6.0%) out of 50 patients treated with Saireito discontinued the drug because of adverse symptoms. The Saireito group was associated with a numerically lower number of episodes of frequent atrial tachyarrhythmias than the control group (3.1 versus 5.2 times, P = 0.17). The mean daily episodes of frequent atrial tachyarrhythmias were significantly fewer in the Saireito group during Day-6 to Day-10 (0.12/day versus 0.27/day, P = 0.03), and during Day-11 to Day-15 (0.08/day versus 0.24/day, P = 0.001). The prevalence of adverse symptoms during the 30-day treatment period was significantly higher in the Saireito group (18.0% versus 2.0%, P = 0.005).<h4>Conclusions</h4>Thirty-day use of Saireito following AF ablation was associated with a tendency toward reduced number of episodes of frequent atrial tachyarrhythmias during the treatment period, with more pronounced effect in the first two weeks.https://doi.org/10.1371/journal.pone.0307854 |
| spellingShingle | Tetsuma Kawaji Satoshi Shizuta Hidenori Yaku Kazuhisa Kaneda Fumiya Yoneda Shushi Nishiwaki Munekazu Tanaka Takanori Aizawa Shun Hojo Kenji Nakatsuma Masashi Kato Takafumi Yokomatsu Shinji Miki Koh Ono Takeshi Kimura Efficacy and safety of Saireito (TJ-114) in patients with atrial fibrillation undergoing catheter ablation procedures: A randomized pilot study. PLoS ONE |
| title | Efficacy and safety of Saireito (TJ-114) in patients with atrial fibrillation undergoing catheter ablation procedures: A randomized pilot study. |
| title_full | Efficacy and safety of Saireito (TJ-114) in patients with atrial fibrillation undergoing catheter ablation procedures: A randomized pilot study. |
| title_fullStr | Efficacy and safety of Saireito (TJ-114) in patients with atrial fibrillation undergoing catheter ablation procedures: A randomized pilot study. |
| title_full_unstemmed | Efficacy and safety of Saireito (TJ-114) in patients with atrial fibrillation undergoing catheter ablation procedures: A randomized pilot study. |
| title_short | Efficacy and safety of Saireito (TJ-114) in patients with atrial fibrillation undergoing catheter ablation procedures: A randomized pilot study. |
| title_sort | efficacy and safety of saireito tj 114 in patients with atrial fibrillation undergoing catheter ablation procedures a randomized pilot study |
| url | https://doi.org/10.1371/journal.pone.0307854 |
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