Aging in Persons with Rett Syndrome: An Updated Review
Rett syndrome (RS) is a neurological disease affecting mainly females, characterized by an arrest of brain development caused by an X-linked mutation. Rett syndrome is the first human disease found to be caused by defects in a protein involved in regulating gene expression through its interaction wi...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2010.79 |
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| _version_ | 1832545844617805824 |
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| author | Meir Lotan Joav Merrick Isack Kandel Mohammed Morad |
| author_facet | Meir Lotan Joav Merrick Isack Kandel Mohammed Morad |
| author_sort | Meir Lotan |
| collection | DOAJ |
| description | Rett syndrome (RS) is a neurological disease affecting mainly females, characterized by an arrest of brain development caused by an X-linked mutation. Rett syndrome is the first human disease found to be caused by defects in a protein involved in regulating gene expression through its interaction with methylated DNA. The disease has been traced to a defective gene called MECP2. The case stories presented here and recent findings show that females with RS are able to live into old age. Due to the observed longevity of individuals with RS, and the fact that individuals with RS present the therapist/physician with specific clinical challenges, it is suggested that proper, long-term, and individually tailored, intensive care should be provided at all ages in the hope to prevent or at least reduce the age-related deterioration that is typical of this population. |
| format | Article |
| id | doaj-art-4f0ffbb511484917bd9c913fe88879f5 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-4f0ffbb511484917bd9c913fe88879f52025-02-03T07:24:31ZengWileyThe Scientific World Journal1537-744X2010-01-011077878710.1100/tsw.2010.79Aging in Persons with Rett Syndrome: An Updated ReviewMeir Lotan0Joav Merrick1Isack Kandel2Mohammed Morad3Department of Physical Therapy, Ariel University Center of Samaria, Ariel, IsraelNational Institute of Child Health and Human Development, Office of the Medical Director, Division for Mental Retardation, Ministry of Social Affairs, Jerusalem, IsraelDepartment of Physical Therapy, Ariel University Center of Samaria, Ariel, IsraelDepartment of Physical Therapy, Ariel University Center of Samaria, Ariel, IsraelRett syndrome (RS) is a neurological disease affecting mainly females, characterized by an arrest of brain development caused by an X-linked mutation. Rett syndrome is the first human disease found to be caused by defects in a protein involved in regulating gene expression through its interaction with methylated DNA. The disease has been traced to a defective gene called MECP2. The case stories presented here and recent findings show that females with RS are able to live into old age. Due to the observed longevity of individuals with RS, and the fact that individuals with RS present the therapist/physician with specific clinical challenges, it is suggested that proper, long-term, and individually tailored, intensive care should be provided at all ages in the hope to prevent or at least reduce the age-related deterioration that is typical of this population.http://dx.doi.org/10.1100/tsw.2010.79 |
| spellingShingle | Meir Lotan Joav Merrick Isack Kandel Mohammed Morad Aging in Persons with Rett Syndrome: An Updated Review The Scientific World Journal |
| title | Aging in Persons with Rett Syndrome: An Updated Review |
| title_full | Aging in Persons with Rett Syndrome: An Updated Review |
| title_fullStr | Aging in Persons with Rett Syndrome: An Updated Review |
| title_full_unstemmed | Aging in Persons with Rett Syndrome: An Updated Review |
| title_short | Aging in Persons with Rett Syndrome: An Updated Review |
| title_sort | aging in persons with rett syndrome an updated review |
| url | http://dx.doi.org/10.1100/tsw.2010.79 |
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