Factors Associated with Gestational Diabetes Mellitus: A Meta-Analysis
Gestational diabetes mellitus (GDM) is a major public health issue, and the aim of the present study was to identify the factors associated with GDM. Databases were searched for observational studies until August 20, 2020. Pooled odds ratios (ORs) were calculated using fixed- or random-effects model...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2021/6692695 |
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| author | Yu Zhang Cheng-Ming Xiao Yan Zhang Qiong Chen Xiao-Qin Zhang Xue-Feng Li Ru-Yue Shao Yi-Meng Gao |
| author_facet | Yu Zhang Cheng-Ming Xiao Yan Zhang Qiong Chen Xiao-Qin Zhang Xue-Feng Li Ru-Yue Shao Yi-Meng Gao |
| author_sort | Yu Zhang |
| collection | DOAJ |
| description | Gestational diabetes mellitus (GDM) is a major public health issue, and the aim of the present study was to identify the factors associated with GDM. Databases were searched for observational studies until August 20, 2020. Pooled odds ratios (ORs) were calculated using fixed- or random-effects models. 103 studies involving 1,826,454 pregnant women were identified. Results indicated that maternal age≥25 years (OR: 2.466, 95% CI: (2.121, 2.866)), prepregnancy overweight or obese (OR: 2.637, 95% CI: (1.561, 4.453)), family history of diabetes (FHD) (OR: 2.326, 95% CI: (1.904, 2.843)), history of GDM (OR: 21.137, 95% CI: (8.785, 50.858)), macrosomia (OR: 2.539, 95% CI: (1.612, 4.000)), stillbirth (OR: 2.341, 95% CI: (1.435, 3.819)), premature delivery (OR: 3.013, 95% CI: (1.569, 5.787)), and pregestational smoking (OR: 2.322, 95% CI: (1.359, 3.967)) increased the risk of GDM with all P<0.05, whereas history of congenital anomaly and abortion, and HIV status showed no correlation with GDM (P>0.05). Being primigravida (OR: 0.752, 95% CI: (0.698, 0.810), P<0.001) reduced the risk of GDM. The factors influencing GDM included maternal age≥25, prepregnancy overweight or obese, FHD, history of GDM, macrosomia, stillbirth, premature delivery, pregestational smoking, and primigravida. |
| format | Article |
| id | doaj-art-4f0f6dd84c8b46408f47fdb26fdc0c1c |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-4f0f6dd84c8b46408f47fdb26fdc0c1c2025-02-03T06:07:16ZengWileyJournal of Diabetes Research2314-67452314-67532021-01-01202110.1155/2021/66926956692695Factors Associated with Gestational Diabetes Mellitus: A Meta-AnalysisYu Zhang0Cheng-Ming Xiao1Yan Zhang2Qiong Chen3Xiao-Qin Zhang4Xue-Feng Li5Ru-Yue Shao6Yi-Meng Gao7Department of Obstetrics and Gynecology, People’s Hospital of Chongqing Banan District, Chongqing 401320, ChinaDepartment of Obstetrics and Gynecology, Liaocheng People’s Hospital and LiaochengClinical School of Shandong First Medical University, Liaocheng, Shandong 252000, ChinaDepartment of Obstetrics and Gynecology, Liaocheng People’s Hospital and LiaochengClinical School of Shandong First Medical University, Liaocheng, Shandong 252000, ChinaDepartment of Obstetrics and Gynecology, People’s Hospital of Chongqing Banan District, Chongqing 401320, ChinaDepartment of Obstetrics and Gynecology, People’s Hospital of Chongqing Banan District, Chongqing 401320, ChinaDepartment of Obstetrics and Gynecology, People’s Hospital of Chongqing Banan District, Chongqing 401320, ChinaSchool of Clinical Medicine, Chongqing Medical and Pharmaceutical College; Chongqing Engineering Research Center of Pharmaceutical Sciences, Shapingba District, Chongqing, 401331, ChinaDepartment of Obstetrics and Gynecology, Liaocheng People’s Hospital and LiaochengClinical School of Shandong First Medical University, Liaocheng, Shandong 252000, ChinaGestational diabetes mellitus (GDM) is a major public health issue, and the aim of the present study was to identify the factors associated with GDM. Databases were searched for observational studies until August 20, 2020. Pooled odds ratios (ORs) were calculated using fixed- or random-effects models. 103 studies involving 1,826,454 pregnant women were identified. Results indicated that maternal age≥25 years (OR: 2.466, 95% CI: (2.121, 2.866)), prepregnancy overweight or obese (OR: 2.637, 95% CI: (1.561, 4.453)), family history of diabetes (FHD) (OR: 2.326, 95% CI: (1.904, 2.843)), history of GDM (OR: 21.137, 95% CI: (8.785, 50.858)), macrosomia (OR: 2.539, 95% CI: (1.612, 4.000)), stillbirth (OR: 2.341, 95% CI: (1.435, 3.819)), premature delivery (OR: 3.013, 95% CI: (1.569, 5.787)), and pregestational smoking (OR: 2.322, 95% CI: (1.359, 3.967)) increased the risk of GDM with all P<0.05, whereas history of congenital anomaly and abortion, and HIV status showed no correlation with GDM (P>0.05). Being primigravida (OR: 0.752, 95% CI: (0.698, 0.810), P<0.001) reduced the risk of GDM. The factors influencing GDM included maternal age≥25, prepregnancy overweight or obese, FHD, history of GDM, macrosomia, stillbirth, premature delivery, pregestational smoking, and primigravida.http://dx.doi.org/10.1155/2021/6692695 |
| spellingShingle | Yu Zhang Cheng-Ming Xiao Yan Zhang Qiong Chen Xiao-Qin Zhang Xue-Feng Li Ru-Yue Shao Yi-Meng Gao Factors Associated with Gestational Diabetes Mellitus: A Meta-Analysis Journal of Diabetes Research |
| title | Factors Associated with Gestational Diabetes Mellitus: A Meta-Analysis |
| title_full | Factors Associated with Gestational Diabetes Mellitus: A Meta-Analysis |
| title_fullStr | Factors Associated with Gestational Diabetes Mellitus: A Meta-Analysis |
| title_full_unstemmed | Factors Associated with Gestational Diabetes Mellitus: A Meta-Analysis |
| title_short | Factors Associated with Gestational Diabetes Mellitus: A Meta-Analysis |
| title_sort | factors associated with gestational diabetes mellitus a meta analysis |
| url | http://dx.doi.org/10.1155/2021/6692695 |
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