Postmastectomy Radiation Therapy: Are We Ready to Individualize Radiation?
Contemporary recommendations for postmastectomy radiation have undergone a shift in thinking away from simple stage based recommendations (one size fits all) to a system that considers both tumor biology and host factors. While surgical staging has traditionally dictated indications for postmastecto...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | International Journal of Breast Cancer |
| Online Access: | http://dx.doi.org/10.1155/2018/1402824 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832567095138713600 |
|---|---|
| author | Ashlyn S. Everett Drexell Hunter Boggs Jennifer F. De Los Santos |
| author_facet | Ashlyn S. Everett Drexell Hunter Boggs Jennifer F. De Los Santos |
| author_sort | Ashlyn S. Everett |
| collection | DOAJ |
| description | Contemporary recommendations for postmastectomy radiation have undergone a shift in thinking away from simple stage based recommendations (one size fits all) to a system that considers both tumor biology and host factors. While surgical staging has traditionally dictated indications for postmastectomy radiation therapy (PMRT), our current understanding of tumor biology, host, immunoprofiles, and tumor microenvironment may direct a more personalized approach to radiation. Understanding the interaction of these variables may permit individualization of adjuvant therapy aimed at appropriate escalation and deescalation, including recommendations for PMRT. This article summarizes the current data regarding tumor and host molecular biomarkers in vitro and in vivo that support the individualization of PMRT and discusses open questions that may alter the future of breast cancer treatment. |
| format | Article |
| id | doaj-art-4f0865ad1b02482eb0d46eef61df5a2d |
| institution | Kabale University |
| issn | 2090-3170 2090-3189 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Breast Cancer |
| spelling | doaj-art-4f0865ad1b02482eb0d46eef61df5a2d2025-02-03T01:02:22ZengWileyInternational Journal of Breast Cancer2090-31702090-31892018-01-01201810.1155/2018/14028241402824Postmastectomy Radiation Therapy: Are We Ready to Individualize Radiation?Ashlyn S. Everett0Drexell Hunter Boggs1Jennifer F. De Los Santos2Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL, USADepartment of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL, USADepartment of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL, USAContemporary recommendations for postmastectomy radiation have undergone a shift in thinking away from simple stage based recommendations (one size fits all) to a system that considers both tumor biology and host factors. While surgical staging has traditionally dictated indications for postmastectomy radiation therapy (PMRT), our current understanding of tumor biology, host, immunoprofiles, and tumor microenvironment may direct a more personalized approach to radiation. Understanding the interaction of these variables may permit individualization of adjuvant therapy aimed at appropriate escalation and deescalation, including recommendations for PMRT. This article summarizes the current data regarding tumor and host molecular biomarkers in vitro and in vivo that support the individualization of PMRT and discusses open questions that may alter the future of breast cancer treatment.http://dx.doi.org/10.1155/2018/1402824 |
| spellingShingle | Ashlyn S. Everett Drexell Hunter Boggs Jennifer F. De Los Santos Postmastectomy Radiation Therapy: Are We Ready to Individualize Radiation? International Journal of Breast Cancer |
| title | Postmastectomy Radiation Therapy: Are We Ready to Individualize Radiation? |
| title_full | Postmastectomy Radiation Therapy: Are We Ready to Individualize Radiation? |
| title_fullStr | Postmastectomy Radiation Therapy: Are We Ready to Individualize Radiation? |
| title_full_unstemmed | Postmastectomy Radiation Therapy: Are We Ready to Individualize Radiation? |
| title_short | Postmastectomy Radiation Therapy: Are We Ready to Individualize Radiation? |
| title_sort | postmastectomy radiation therapy are we ready to individualize radiation |
| url | http://dx.doi.org/10.1155/2018/1402824 |
| work_keys_str_mv | AT ashlynseverett postmastectomyradiationtherapyarewereadytoindividualizeradiation AT drexellhunterboggs postmastectomyradiationtherapyarewereadytoindividualizeradiation AT jenniferfdelossantos postmastectomyradiationtherapyarewereadytoindividualizeradiation |