Inhibitory Effects of Apigenin on Tumor Carcinogenesis by Altering the Gut Microbiota
The flavonoid apigenin is common to many plants. Although the responsible mechanisms have yet to be elucidated, apigenin demonstrates tumor suppression in vitro and in vivo. This study uses an azoxymethane (AOM)/dextran sodium sulfate- (DSS-) induced colon cancer mouse model to investigate apigenin’...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2020/7141970 |
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| author | Shichang Bian Hongjuan Wan Xinyan Liao Weisheng Wang |
| author_facet | Shichang Bian Hongjuan Wan Xinyan Liao Weisheng Wang |
| author_sort | Shichang Bian |
| collection | DOAJ |
| description | The flavonoid apigenin is common to many plants. Although the responsible mechanisms have yet to be elucidated, apigenin demonstrates tumor suppression in vitro and in vivo. This study uses an azoxymethane (AOM)/dextran sodium sulfate- (DSS-) induced colon cancer mouse model to investigate apigenin’s potential mechanism of action exerted through its effects upon gut microbiota. The size and quantity of tumors were reduced significantly in the apigenin treatment group. Using 16S rRNA high-throughput sequencing of fecal samples, the composition of gut microbiota was significantly affected by apigenin. Further experiments in which gut microbiota were reduced and feces were transplanted provided further evidence of apigenin-modulated gut microbiota exerting antitumor effects. Apigenin was unable to reduce the number or size of tumors when gut microbiota were depleted. Moreover, tumor inhibition effects were initiated following the transplant of feces from mice treated with apigenin. Our findings suggest that the effect of apigenin on the composition of gut microbiota can suppress tumors. |
| format | Article |
| id | doaj-art-4f07abcbd36f4576a31975123f9b7768 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-4f07abcbd36f4576a31975123f9b77682025-02-03T01:20:09ZengWileyMediators of Inflammation0962-93511466-18612020-01-01202010.1155/2020/71419707141970Inhibitory Effects of Apigenin on Tumor Carcinogenesis by Altering the Gut MicrobiotaShichang Bian0Hongjuan Wan1Xinyan Liao2Weisheng Wang3Tianjin Fourth Central Hospital, The Fourth Central Hospital Affiliated to Nankai University, The Fourth Central Clinical College, Tianjin Medical University, Tianjin, ChinaTianjin Fourth Central Hospital, The Fourth Central Hospital Affiliated to Nankai University, The Fourth Central Clinical College, Tianjin Medical University, Tianjin, ChinaTianjin Fourth Central Hospital, The Fourth Central Hospital Affiliated to Nankai University, The Fourth Central Clinical College, Tianjin Medical University, Tianjin, ChinaTianjin Fourth Central Hospital, The Fourth Central Hospital Affiliated to Nankai University, The Fourth Central Clinical College, Tianjin Medical University, Tianjin, ChinaThe flavonoid apigenin is common to many plants. Although the responsible mechanisms have yet to be elucidated, apigenin demonstrates tumor suppression in vitro and in vivo. This study uses an azoxymethane (AOM)/dextran sodium sulfate- (DSS-) induced colon cancer mouse model to investigate apigenin’s potential mechanism of action exerted through its effects upon gut microbiota. The size and quantity of tumors were reduced significantly in the apigenin treatment group. Using 16S rRNA high-throughput sequencing of fecal samples, the composition of gut microbiota was significantly affected by apigenin. Further experiments in which gut microbiota were reduced and feces were transplanted provided further evidence of apigenin-modulated gut microbiota exerting antitumor effects. Apigenin was unable to reduce the number or size of tumors when gut microbiota were depleted. Moreover, tumor inhibition effects were initiated following the transplant of feces from mice treated with apigenin. Our findings suggest that the effect of apigenin on the composition of gut microbiota can suppress tumors.http://dx.doi.org/10.1155/2020/7141970 |
| spellingShingle | Shichang Bian Hongjuan Wan Xinyan Liao Weisheng Wang Inhibitory Effects of Apigenin on Tumor Carcinogenesis by Altering the Gut Microbiota Mediators of Inflammation |
| title | Inhibitory Effects of Apigenin on Tumor Carcinogenesis by Altering the Gut Microbiota |
| title_full | Inhibitory Effects of Apigenin on Tumor Carcinogenesis by Altering the Gut Microbiota |
| title_fullStr | Inhibitory Effects of Apigenin on Tumor Carcinogenesis by Altering the Gut Microbiota |
| title_full_unstemmed | Inhibitory Effects of Apigenin on Tumor Carcinogenesis by Altering the Gut Microbiota |
| title_short | Inhibitory Effects of Apigenin on Tumor Carcinogenesis by Altering the Gut Microbiota |
| title_sort | inhibitory effects of apigenin on tumor carcinogenesis by altering the gut microbiota |
| url | http://dx.doi.org/10.1155/2020/7141970 |
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