The Role of PAM4 in the Management of Pancreatic Cancer: Diagnosis, Radioimmunodetection, and Radioimmunotherapy
PAM4, a new monoclonal antibody (MAb) known as clivatuzumab, is highly reactive with pancreatic cancer and precursor lesions. It is absent from the normal tissues and has limited reactivity with nonpancreatic cancer. The detailed characteristic of the PAM4 epitope is unknown but recent studies have...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2014/268479 |
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| _version_ | 1832563769813762048 |
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| author | Suxia Han Guihua Jin Lijuan Wang Meng Li Chenchen He Xijing Guo Qing Zhu |
| author_facet | Suxia Han Guihua Jin Lijuan Wang Meng Li Chenchen He Xijing Guo Qing Zhu |
| author_sort | Suxia Han |
| collection | DOAJ |
| description | PAM4, a new monoclonal antibody (MAb) known as clivatuzumab, is highly reactive with pancreatic cancer and precursor lesions. It is absent from the normal tissues and has limited reactivity with nonpancreatic cancer. The detailed characteristic of the PAM4 epitope is unknown but recent studies have shown that it is dependent on MUC1 glycosylation status. The limited PAM4 expression pattern makes it an attractive candidate for management of pancreatic adenocarcinoma. In addition, PAM4 is a serum biomarker for diagnosis of pancreatic cancer. Several different radiolabeled immunodiagnostic and immunotherapeutic agents of PAM4 have been developed and some are being evaluated in preclinical and/or clinical studies. The review will focus on PAM4 and its potential utility for the diagnosis, radioimmunodetection, and radioimmunotherapy of pancreatic cancer. |
| format | Article |
| id | doaj-art-4efb79c4d40d48f38ec843bf248fca16 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-4efb79c4d40d48f38ec843bf248fca162025-02-03T01:12:34ZengWileyJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/268479268479The Role of PAM4 in the Management of Pancreatic Cancer: Diagnosis, Radioimmunodetection, and RadioimmunotherapySuxia Han0Guihua Jin1Lijuan Wang2Meng Li3Chenchen He4Xijing Guo5Qing Zhu6Department of Medical Oncology, The First Affiliated Hospital of Xi’an Jiaotong University Medical Center, Xi’an, Shannxi 710061, ChinaDepartment of Medical Oncology, The First Affiliated Hospital of Xi’an Jiaotong University Medical Center, Xi’an, Shannxi 710061, ChinaDepartment of Medical Oncology, The First Affiliated Hospital of Xi’an Jiaotong University Medical Center, Xi’an, Shannxi 710061, ChinaDepartment of Medical Oncology, The First Affiliated Hospital of Xi’an Jiaotong University Medical Center, Xi’an, Shannxi 710061, ChinaDepartment of Medical Oncology, The First Affiliated Hospital of Xi’an Jiaotong University Medical Center, Xi’an, Shannxi 710061, ChinaDepartment of Medical Oncology, The First Affiliated Hospital of Xi’an Jiaotong University Medical Center, Xi’an, Shannxi 710061, ChinaDepartment of Medical Oncology, The First Affiliated Hospital of Xi’an Jiaotong University Medical Center, Xi’an, Shannxi 710061, ChinaPAM4, a new monoclonal antibody (MAb) known as clivatuzumab, is highly reactive with pancreatic cancer and precursor lesions. It is absent from the normal tissues and has limited reactivity with nonpancreatic cancer. The detailed characteristic of the PAM4 epitope is unknown but recent studies have shown that it is dependent on MUC1 glycosylation status. The limited PAM4 expression pattern makes it an attractive candidate for management of pancreatic adenocarcinoma. In addition, PAM4 is a serum biomarker for diagnosis of pancreatic cancer. Several different radiolabeled immunodiagnostic and immunotherapeutic agents of PAM4 have been developed and some are being evaluated in preclinical and/or clinical studies. The review will focus on PAM4 and its potential utility for the diagnosis, radioimmunodetection, and radioimmunotherapy of pancreatic cancer.http://dx.doi.org/10.1155/2014/268479 |
| spellingShingle | Suxia Han Guihua Jin Lijuan Wang Meng Li Chenchen He Xijing Guo Qing Zhu The Role of PAM4 in the Management of Pancreatic Cancer: Diagnosis, Radioimmunodetection, and Radioimmunotherapy Journal of Immunology Research |
| title | The Role of PAM4 in the Management of Pancreatic Cancer: Diagnosis, Radioimmunodetection, and Radioimmunotherapy |
| title_full | The Role of PAM4 in the Management of Pancreatic Cancer: Diagnosis, Radioimmunodetection, and Radioimmunotherapy |
| title_fullStr | The Role of PAM4 in the Management of Pancreatic Cancer: Diagnosis, Radioimmunodetection, and Radioimmunotherapy |
| title_full_unstemmed | The Role of PAM4 in the Management of Pancreatic Cancer: Diagnosis, Radioimmunodetection, and Radioimmunotherapy |
| title_short | The Role of PAM4 in the Management of Pancreatic Cancer: Diagnosis, Radioimmunodetection, and Radioimmunotherapy |
| title_sort | role of pam4 in the management of pancreatic cancer diagnosis radioimmunodetection and radioimmunotherapy |
| url | http://dx.doi.org/10.1155/2014/268479 |
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