Discovery of conserved peptide-MHC epitopes for directly alloreactive CD8+ T cells

Discovery of conserved peptide-MHC epitopes for directly alloreactive CD8+ T cells

Mass Spectrometry allied with in-vivo generation of activated alloreactive T cell populations and tetramer screening facilitates the identification of endogenous peptides that are directly recognised in complex with allogeneic Major Histocompatibility class I (MHC I) molecules by alloreactive CD8+ T...

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Bibliographic Details
Main Authors: Alexandra E. Hill, Eric T. Son, Moumita Paul-Heng, Chuanmin Wang, Shivanjali Ratnaseelan, Martina Denkova, Pouya Faridi, Asolina Braun, Anthony W. Purcell, Nicole A. Mifsud, Alexandra F. Sharland
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Transplantation
Subjects:
allorecognition
peptide-MHC
CD8+ T cell
epitope discovery
heart transplant
acute rejection
Online Access:https://www.frontiersin.org/articles/10.3389/frtra.2025.1525003/full
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